Top Tweets for #mglu5
健常mouseで認められる海馬のmGlu5受容体発現の左優位性がAlzheimer病modelでは消失
光制御薬Alloswitch-1での左海馬mGlu5選択的阻害が記憶障害改善/海馬tau過剰燐酸化抑制
逆説的だがmGlu5R発現量と受容体を介した病的signal伝達は異なると
#Alzheimers
#mGlu5
#papers
https://t.co/UFE6BwOEEf
Data from a landmark study published in Brain demonstrates the potential therapeutic role of #mGlu5 receptor negative #allostericmodulators (NAMs) in facilitating functional recovery following #stroke. At Addex, we believe this supports the future development of #dipraglurant in
Today, we announced data published in Cells showing that #dipraglurant could have beneficial effects on non-motor symptoms experienced by #Parkinson’s patients, in addition to its established positive effects on dyskinesias. Dipraglurant is an #mGlu5 negative #allostericmodulator
@carlyfabian231's new review on sex differences and hormonal regulation of mGlu receptor plasticity is now online! #mGlu5 @SeneyMarianne
https://t.co/ajGNlKRvar
This could result in substantial visual disturbance or functional #blindness. Dipraglurant selectively targets the metabotropic #glutamate receptor subtype 5 (#mGlu5) to downregulate the neurotransmission causing the spasm through allosteric modulation.
#HTL14242 is an advanced and orally active #mGlu5 #NAM with a pKi and a pIC50 of 9.3 and 9.2, respectively. HTL14242 can be used for the research of #parkinson’s disease. #drugdiscovery. https://t.co/2K0lCNP7QW
Let’s goooooo #mGlu5
Thanks to @jamesrmelchior for setting this up but I can’t find you on the leaderboard??
@SamCentanni has some catching up to do
super excited to share that one (of my last?) papers from my time with Karen Szumlinski has been accepted! 1/6
https://t.co/vvSKsSA74E
((special s/o to first author @foaltz ))
Only took me 3 days not to go my usual way to lab (now locked) and to get my temp checked first #reversallearning #extinction #prefrontalcortex #mGlu5
My weirdest alliterative segment yet: FBS Friday! These delicious serum sacks are FBS we've been dialysing to get rid of pesky amino acids, which are confounding factors in our #mGlu5 assays🙅
Also, further proof that rubberbands are legit science equipment! #saynotoglutamine
"Training Thursday" cont! Now teaching calcium imaging to a visiting masters student, to look at the effects of phosphorylation site mutants on #mGlu5 desensitisation.
Good looking science is the best science, right?! 🧫➡️🔅➡️📈
#neuroscience @AcademicChatter #ECR @EMCR_MIPS
In @SfNJournals #eNeuro by @women_neurosci, @ZhiminSong & others, "#Estradiol-Induced #Potentiation of #Dopamine Release in #Dorsal #Striatum Following #Amphetamine Administration Requires Estradiol #Receptors and #mGlu5." https://t.co/3AKh5JDASA #Addiction #DrugAbuse #Hormones
SO, SO EXCITED for @riannethoughts for getting this paper out (we worked on it together back at #UCSB) Increased #alcohol-drinking induced by manipulations of #mGlu5 phosphorylation within the #BNST https://t.co/5PXOg7l1AK
#Cannabis: des #rats mâles exposés in utero aux #cannabinoïdes sont moins sociables que leurs congénères et présentent des déficits #comportementaux et #neuronaux à l'âge adulte. La voie de signalisation #mGlu5 pourrait être une cible thérapeutique https://t.co/2t0SWXJ1TC @Inserm
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