Top Tweets for #pr_p
#Apixaban is a FXa inhibitor and #anticoagulant for patients with nonvalvular atrial fibrillation. Wong and Crain calibrated a rabbit model of electrolytic-mediated arterial thrombosis to predict in vivo therapeutic drug exposure of FXa inhibitors. #PR_P
https://t.co/0MEUNfDMFU
SGLT2 inhibitors suppress cardiovascular events in subjects with type 2 #diabetes and #atherosclerosis. Iwamoto et al found that tofogliflozin suppresses atherosclerosis by improving glucose intolerance associated with inhibition of #inflammation. #PR_P
https://t.co/6VYtkGAD6A
Single-inhaler BDP/FF/GB is available for management of #asthma, yet it has not been evaluated in adolescents. Kuna et al have found that there are no safety concerns to warrant reduced dosing for adolescents compared to adults. #Pharmacodynamics #PR_P
https://t.co/DJfAuNV0in
Network #pharmacology can detail the natural components of Triptergium wilfordii Hook F, #TwHF. Xu et al have found that isolated components of TwHF effectively reduce #proteinuria and alleviate the tubular interstitial changes in rat models of #diabetic #nephropathy. #PR_P
Numerous studies have evaluated the efficacy of adipose tissue-derived stem cells and their #exosome transplantation in managing #Alzheimer's disease. Neishaboori et al have reviewed existing evidence regarding their efficacy in our recent review. #PR_P
https://t.co/VsOSoFJmv6
Efficacy of a #therapeutic response can vary by population. Chen et al have performed a retrospective analysis to evaluate the #efficacy of #Atezolizumab in Chinese patients with stage IV #NSCLC. #Cancer #Pharmacodynamics #Pharmacokinetics #PR_P
https://t.co/Gng5GbObOZ
#5FU is an #FDA approved treatment option for pancreatic #cancer. Russell et al., have used a #murine model to create a simplified metabolic pathway of the 5FU prodrug, #capecitabine. #Pharmacokinetics #Pharmacology #PR_P
https://t.co/KPmPVBcyHA
Cancer #pharmacology pulls ahead! Recently, AbuSara et al. investigated the use of #vancomycin in #cancer patients and found that underestimation of dosing is associated with augmented renal clearance. #Pharmacokinetics #PR_P #Polls_PRP
https://t.co/olzS6m3PHE
Antagonism of α-adrenoceptors can have #antidepressant and #antipsychotic #therapeutic properties. Proudman et al., have characterized the affinity and selectivity of 99 antagonists for α-adrenoceptor subtypes! #Pharmacokinetics #Pharmacology #PR_P
https://t.co/TN1K9t7wSI
#Voriconazole treats a variety of invasive fungal diseases. However, it exhibits non-linear #pharmacokinetics. Aiuchi et al., have identified #CYP2C19 #polymorphism as a useful predictor for determining Voriconazole dosage. #Pharmacology #PR_P
https://t.co/HLd4SXr7Ui
#Tamsulosin treats symptoms associated with benign enlargement of the #prostate. Russom et al., evaluated the link between tamsulosin and #priapism and found a causal relationship! #MensHealth #Pharmacology #PR_P
https://t.co/4lPyJkLA69
#Opioids target mu-opioid receptors (MORs) in the #brain to produce #pain relieving effects. Shimizu and Shiraki developed a neuronal cell line to study the physiological regulation of MOR by using #CRISPR/Cas9 technology. #Neuroscience #Pharmacology #PR_P
https://t.co/J9vHwa0LRT
#Antibiotics, such as #fluoroquinolones, treat bacterial #infections. However, they can have serious adverse reactions. Kuula et al., assessed #healthcare costs and the risk of mortality associated with those adverse reactions! #Pharmacology #PR_P
https://t.co/fshL5t9wPP
#Honokiol exerts cardio-protective effects on chemical-induced cardiotoxicity. Huang et al. have shown that Honokiol alleviates the cardiotoxic effects of ATO, an effective therapeutic for acute promyelocytic leukemia. #Oncology #Pharmacology #PR_P
https://t.co/9Fv074Qbb1
#MDR1 substrates within the blood brain barrier have restricted access to the #CNS. Jiang et al. have found MDR1-MDCKI cells from the #NIH to be a reliable in vitro tool for determining the in vivo brain penetrance of drug candidates. #Pharmacology #PR_P
https://t.co/g2y3wCDW5X
Pharmaceutical excipients improve the #bioavailability of drugs. Cao et al. have characterized how the excipient #PEG400 effects the absorption of #Biacalein, a potential candidate for #cancer treatment. #Metabolism #Pharmacokinetics #Pharmacology #PR_P
https://t.co/gvpodthQbB
Animal experiments provide an effective approach to teaching #pharmacology, but it is crucial to be mindful of the #ethical considerations. Lawson et al. have shown that digital learning can be an equally effective approach to knowledge acquisition! #PR_P
https://t.co/4xwyGrh9iY
~40% of #COVID-19 patients experience “LONG COVID”, where symptoms such as brain fog and loss of #taste or #smell last for at least 12 weeks. Jarrott et al. suggest that clinical investigation of #melatonin may lead to potential treatment options. #PR_P
https://t.co/ES2jFUu8NE
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