Top Tweets for #revtorpyk
🆕 Breaking from the FDA: @Celcuity’s #Revtorpyk has been approved for adults with hormone receptor-positive, HER2-negative #BreastCancer in combination with fulvestrant.
The approval also allows for @Pfizer’s #Ibrance to be added to the combination. https://t.co/cRNeOKnOQ2
🌟 This week's #OncFive 🌟:
🎗️ FDA approves gedatolisib (#Revtorpyk) in PIK3CA WT HR+/HER2- mBC
🧬 Selpercatinib (#Retevmo) full approval in RET fusion+ tumors
🚫 3rd CRL for rivoceranib + camrelizumab in 1L HCC
🩸 NDA accepted for mezigdomide combo in r/r myeloma
🟡 Fast track for SOT109 ADC in advanced CRC
Learn more 🔗: https://t.co/FwRkGaSNAC
❗ The #FDA approved @Celcuity’s #Revtorpyk ➕ fulvestrant, with or without @Pfizer’s #Ibrance, for adults with hormone receptor-positive, HER2-negative #BreastCancer.
The combination improved PFS by 7️⃣6️⃣% compared with fulvestrant alone. https://t.co/go1S3rfEjk
💊#FDA承認 アップデート | FDAは、内分泌療法後に病勢進行した #HR陽性・#HER2陰性・#PIK3CA 野生型の局所進行性または転移性乳がん成人患者に対し、#Revtorpyk（#ゲダトリシブ）を #フルベストラント との併用療法（#パルボシクリブ 併用の有無を問わず）として承認しました。
💡ゲダトリシブは、クラスI PI3Kの全アイソフォームおよびmTORC1/2複合体の両方を同時に標的とするpan-PI3K/mTOR阻害剤です。内分泌療法耐性を促進する重要なシグナル伝達経路を阻害します。
📊VIKTORIA-1
🔹ゲダトリシブ＋パルボシクリブ＋フルベストラント併用群は、フルベストラント単独群と比較して、疾患進行または死亡リスクを76%低減
🔹無増悪生存期間（PFS）中央値：9.3か月 vs 2.0か月
🔹PIK3CA野生型患者において有意な治療効果を確認
#乳がん #HR陽性 #HER2陰性 #PI3K #腫瘍学 #がん研究 #創薬 #医薬品化学
💊#FDAApproval Update | The FDA has approved #Revtorpyk (#gedatolisib) in combination with #fulvestrant, with/without #palbociclib, for adults with #HR-positive, #HER2-negative, #PIK3CA wild-type locally advanced or metastatic breast cancer following progression on endocrine therapy.
💡Gedatolisib is a pan-PI3K/mTOR inhibitor, simultaneously targeting all class I PI3K isoforms and both mTORC1/2 complexes to inhibit a key signaling pathway driving endocrine resistance.
📊VIKTORIA-1 trial:
🔹76% reduction in the risk of disease progression or death with gedatolisib + palbociclib + fulvestrant vs fulvestrant alone
🔹Median progression-free survival: 9.3 vs 2.0 months
🔹Significant benefit observed in patients with PIK3CA wild-type disease
#BreastCancer #HRPositive #HER2Negative #PI3K #Oncology #CancerResearch #DrugDiscovery #MedicinalChemistry
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