Hee-Hoon Kim

Postdoctoral Associate @Yale, Dixit Lab (Aging & Immunometabolism) / PhD at KAIST GSMSE (Liver diseases and obesity)

[Hee-Hoon Kim @Hee_Hoon_Kim]

1st author paper in Nature Aging🥳
Unbiased CALERIE participants' exoproteome analysis and a reverse translational study found inhibition of C3a, a complement component, is an inflammaging checkpoint. 1/
Kudos to @MishraManish29 @VishwaDeepDixi1 and team!

https://t.co/UjWUIetnr1

[Jang Hyun (Jay) Park @janghyun_park_]

🧵Excited to share my first author paper in @Nature from @kipnislab. "Functional role of skull lymphoid structures in CNS immunosurveillance" https://t.co/2do14Jj1rB

[Hee-Hoon Kim @Hee_Hoon_Kim]

@janghyun_park_ @kipnislab @jonykipnis Huge congrats!!!!!!!

[Jang Hyun (Jay) Park @janghyun_park_]

So exciting to finally see this paper out!
This work was only possible thanks to our amazing collaborators and everyone in the @kipnislab. I am especially grateful to @jonykipnis for his tremendous support and mentorship throughout this work.

[Jonathan Kipnis 🟦 @jonykipnis]

Excited to share our new work by Jay Park @janghyun_park_ and friends! Jay found lymphoid structures in the skull bone marrow that seem to be serving immune hub role for the brain... brain, after all, may not be using "common lymph nodes" but rather has its own unique immune hubs and Jay showed their role in brain tumors... but their role in likely much more than that. This is a long paper but it is worth the read || https://t.co/Im4zCdqmQQ

[Cell Metabolism @Cell_Metabolism]

New! Online now: A single-cell multi-omic atlas of the human pancreas reveals potential for cellular plasticity across development, health, and disease https://t.co/cidtiZp1QV

[Ernesto Abila @abila_ernesto]

🎉 Our tissue clocks paper is now out in Nature Medicine!

We quantified biological age from ~25k histology images of 983 GTEx donors and showed the signal can be read from blood. 📄
https://t.co/ZUOpU91GYj

[David M. Sabatini @DMSabatini]

Excited to see @AniaPuszynska's work on lysosomal aging and a new aging clock out in print.

Congratulations to Ania and everyone involved!

Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disorders | Science https://t.co/BikyHNIHPU

[nature @Nature]

Nature research paper: A queen odour mediates reproductive suppression in a eusocial mammal

https://t.co/hlDqASa5tm

[Hee-Hoon Kim @Hee_Hoon_Kim]

@MishraManish29 Thanks Manish!!

[Hee-Hoon Kim @Hee_Hoon_Kim]

Thrilled to share a co-first author paper in Clin Mol Hepatol (IF=21.7)🎉

🧐Why only a subset of alcohol-related steatosis patients progress to hepatitis?

- A secret of the protective BM-liver axis

In collaboration with my wife, Dr. Young-Ri Shim😊

https://t.co/hHce7ZJp6S

[Yale Center for Research on Aging (Y-Age) @YaleAge]

We seek to fill a tenure-track faculty position at the Assistant or Associate Professor Level (PhD or MD/DVM/PhD) to build an interdisciplinary research program here at @YaleAge, part of @YalePathology & @YaleMed. #pathologyjobs Learn more & apply here: https://t.co/xPvj6fuSH8

[Hee-Hoon Kim @Hee_Hoon_Kim]

This work was led by my wife, Dr. Young-Ri Shim. I’m deeply grateful to have contributed as co-first author, and I also want to sincerely thank all of our co-authors and collaborators for making this study possible. I can't wait for more collaborations with my wife 😆 8/8

[Hee-Hoon Kim @Hee_Hoon_Kim]

Moreover, our findings identify IL-1R2 as a novel "adaptokine"—a secreted protein induced by cellular or organismal stress to maintain immune-metabolic homeostasis. 7/

[Hee-Hoon Kim @Hee_Hoon_Kim]

💡 Why it matters: This study strengthens the importance of the BM–liver axis in controlling alcohol-associated inflammation—and suggests translational opportunities, including IL-1R2⁺ monocyte–based cell therapy and recombinant IL-1R2 as potential therapeutic strategies. 6/

[Hee-Hoon Kim @Hee_Hoon_Kim]

👥 Importantly, in patients with chronic alcohol consumption, we also observed increased IL-1R2⁺ monocytes in blood and liver, supporting clinical relevance. 5/

[Hee-Hoon Kim @Hee_Hoon_Kim]

🧭 These IL-1R2⁺ monocytes migrate through the blood into the liver and attenuate alcohol-associated inflammation, delaying disease progression. 4/

[Hee-Hoon Kim @Hee_Hoon_Kim]

🚦 In neighboring BM monocytes, IFN-γ signaling increases IL-1R2 (a decoy receptor) while reducing CX3CR1, promoting egress from the BM. 3/

[Hee-Hoon Kim @Hee_Hoon_Kim]

🕑 Glutamate–mGluR5 signaling in recruited NK cells boosts IFN-γ production in the BM. 2/

[Hee-Hoon Kim @Hee_Hoon_Kim]

🍺 With chronic alcohol exposure, LepR⁺ bone marrow MSCs metabolize alcohol, experience oxidative stress, and excrete glutamate via the xCT transporter—along with increased chemokine ligands that help recruit immune cells. 1/

[Cell Metabolism @Cell_Metabolism]

New! Online now: The senescence-stiffening loop: Extracellular matrix remodeling, hypoperfusion, and mitochondrial dysfunction drive tissue aging https://t.co/hnlhb6qKz7