How, When & WHI

Your professional resource for information on the rational use of hormone therapy to manage the symptoms of menopause.

[How, When & WHI @HowWhenWHI]

Before menopause, women are 3X less likely to have a heart attack than men. After menopause, they have an equal chance

[How, When & WHI @HowWhenWHI]

The WHI included randomized trials of a low-fat dietary pattern, calcium and vitamin D supplementation, and postmenopausal hormone use

[How, When & WHI @HowWhenWHI]

The mean age of the women participating in the hormone therapy arm of the WHI trial was 63 years

[How, When & WHI @HowWhenWHI]

The “timing” hypothesis suggests younger symptomatic women treated with HT at menopause onset may be protected from CHD

[How, When & WHI @HowWhenWHI]

WHI is the largest clinical trial investigating common causes of morbidity and mortality among postmenopausal women

[How, When & WHI @HowWhenWHI]

Menopause is the absence of menstruation for a full year from the last menstrual period, a definition that has been consistent for decades

[How, When & WHI @HowWhenWHI]

The most common menopause symptoms are vasomotor symptoms, usually described as night sweats, hot flashes, flushes, and vaginal dryness

[How, When & WHI @HowWhenWHI]

The approach used to manage the signs and symptoms of menopause often boils down to which of the body’s estrogen receptors to affect

[How, When & WHI @HowWhenWHI]

14th Annual Women’s Health Update at the Mayo Clinic starts today

[How, When & WHI @HowWhenWHI]

While the vasomotor symptoms of menopause generally improve over time, vaginal symptoms usually worsen and do not improve without treatment

[How, When & WHI @HowWhenWHI]

The “timing” hypothesis suggests older women treated with HT for the first time have no benefit and may have early harm

[How, When & WHI @HowWhenWHI]

The balance of benefits and risks for HT is most favorable within the first ten years of menopause, or up to around 60 years of age

[How, When & WHI @HowWhenWHI]

1 in 4 women are affected by osteoporosis after menopause

[How, When & WHI @HowWhenWHI]

The WHI intervention lasted a median of 5.6 years in CEE plus MPA and 7.2 years in CEE alone, with 13 years of cumulative follow-up

[How, When & WHI @HowWhenWHI]

WHI was the first randomized trial to directly assess whether oral CEE plus MPA affected CHD risk in healthy postmenopausal women.

[How, When & WHI @HowWhenWHI]

Hot flushes may begin in the perimenopausal period months or years before menopause.

[How, When & WHI @HowWhenWHI]

The decreasing amount of ovarian estrogen that characterizes the perimenopause, affects as many as 300 different body parts.

[How, When & WHI @HowWhenWHI]

In general, the alpha receptors are involved in the reproductive system while the beta receptors are active in other body tissues.

[How, When & WHI @HowWhenWHI]

One in two postmenopausal women in the United States will suffer from a fracture related to osteoporosis during their lifetime.

[How, When & WHI @HowWhenWHI]

It is a common misperception that WHI excluded symptomatic menopausal women; it only excluded symptomatic women who could not stop HT.