Hidradenitis Suppurativa Genetics Consortium

working to provide an HS diagnosis that is accurate and actionable | discover, disseminate, and educate | building bridges among stakeholders

[Hidradenitis Suppurativa Genetics Consortium @HS_genetics]

Conducting genetic studies with rigor and in large cohorts of diverse research participants will create opportunities to improve care for patients with #HidradenitisSuppurativa

https://t.co/Zz21uXht7E

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[The Dermatology Digest @derm_digest]

Review this year's top #HidradenitisSuppurativa headlines and breaking news with The Derm Digest. See the complete archive of HS articles: https://t.co/RknALwINuB

[Hidradenitis Suppurativa Genetics Consortium @HS_genetics]

Genetic studies of #HS increasingly implicate the #hair follicle in pathogenesis. While working on this review of hair trait #GWAS we came across a hair gene reported in an HS GWAS from @gbj_jemec.

We are excited to see which hair genes will be found next in #hidradenitis GWAS!

[Lynn Petukhova @LynnPetukhova]

#Genetic studies of #hair traits that vary within and across populations create opportunities to generate new clinically relevant knowledge about physiology that is fundamental to human #health and #medicine

https://t.co/Jb3pymfiEL

[Lynn Petukhova @LynnPetukhova]

more evidence that inborn errors of immunity are under diagnosed among #23_L individuals with #hidradenitissuppurativa #HS

[Hidradenitis Suppurativa Genetics Consortium @HS_genetics]

our genetic studies of #HidradenitisSuppurativa are designed to improve its clinical management

[Lynn Petukhova @LynnPetukhova]

Columbia University Mailman School of Public Health is ranked third in the nation for NIH Prime Awards to schools of public health for 2023 including $3.6M to study #hidradenitissuppurativa #HS

[Hidradenitis Suppurativa Genetics Consortium @HS_genetics]

A greater awareness of what single-gene causes of skin disease look like in clinical practice can benefit everyone.

[Lynn Petukhova @LynnPetukhova]

Dear #dermtwitter

Are single-gene causes of skin disease under-recognized in clinical practice?

We argue yes. And that there are opportunities today for identifying them and using that information to improve the management of skin disease.

https://t.co/5F3ZtXUTUk

[Hidradenitis Suppurativa Genetics Consortium @HS_genetics]

Come learn about the work that our group is doing to advance our knowledge about causes and cures for #HidradenitisSuppurativa

[Hidradenitis Suppurativa Genetics Consortium @HS_genetics]

What does it mean to say that a disease is genetic?

Why are we conducting genetic studies of #HidradenitisSuppurativa ?

Why do we need help from thousands of people with #HS ?

All good questions. Some answers here:

https://t.co/xEfHNPsq6s

[Hidradenitis Suppurativa Genetics Consortium @HS_genetics]

Bigger #HidradenitisSuppurativa cohorts will identify more risk variants. Our group is working on this!

[Hidradenitis Suppurativa Genetics Consortium @HS_genetics]

Statistical evidence for an association is just the start.

Its like purchasing an airline ticket. You know where you will be heading, but there is still work to do in planning the visit before you can enjoy the experience.

🧵

https://t.co/qz6tznWcKt

[Hidradenitis Suppurativa Genetics Consortium @HS_genetics]

Both of the regions contain genes that are active in the hair follicle!

However, we need experiments to determine if the genes are being influenced by the #HS risk variants.

We also need more risk variants identified to better vet out the relationship between HS and asthma.

[Hidradenitis Suppurativa Genetics Consortium @HS_genetics]

See how we are leveraging knowledge about single-gene disorders to efficiently improve our understanding of the genetic architecture of #HidradenitisSuppurativa

#WCD2023Singapore

Suntan 308/309 at 14:30 today!

[Lynn Petukhova @LynnPetukhova]

Sharing more of our work today @wcd2023sg

Join us in Suntec 308/309 at 14:30 to see how we are using exome sequencing to resolve the immunological landscape of #HidradenitisSuppurativa

[Hidradenitis Suppurativa Genetics Consortium @HS_genetics]

So many new unpublished results!

And some explanations of how we are using human genetic studies to improve the clinical management of #HidradenitisSuppurativa

#WCD2023Singapore

Sister Society meeting of HS today at 1:30

[Lynn Petukhova @LynnPetukhova]

Join us @wcd2023sg today.

Our group is sharing unpublished exciting preliminary results from our #HidradenitisSuppurativa genetic studies

[Hidradenitis Suppurativa Genetics Consortium @HS_genetics]

Looking forward to catching up with colleagues in person and hoping to further expand our network of collaborators for #HidradenitisSuppurativa genetic studies.

#WCD2023Singapore

[Lynn Petukhova @LynnPetukhova]

Looking forward to sharing updates about the work we are doing to improve our knowledge about #HidradenitisSuppurativa causes and cures at #WCD2023Singapore

[Hidradenitis Suppurativa Genetics Consortium @HS_genetics]

Our group is making great progress in exploring this hypothesis about the genetic architecture of #hidradenitissuppurativa.

We are open to new collaborations if you are interested in joining our efforts.

[Hidradenitis Suppurativa Genetics Consortium @HS_genetics]

Single-gene disorders contribute to the population burden of many common diseases and we believe that there are many more contributing to the prevalence of #HidradenitisSuppurativa.

Identifying #23_L patients with inborn errors of immunity has important clinical implications

[Casanova Lab @casanova_lab]

Terrific review about IEI underlying HS (aka more accurately as maladie de Verneuil) 😉
Inborn Errors of Immunity in Hidradenitis Suppurativa Pathogenesis and Disease Burden https://t.co/3kXw7kEj68

[Hidradenitis Suppurativa Genetics Consortium @HS_genetics]

for themselves and their family members, and also provides valuable information about #HS causes and cures for patients who don't have a disease-causing mutation.