iGEM HU Berlin

#SynBio Team of @HumboldtUni, participating in the #iGEM contest 2021.
[email protected]

[iGEM HU Berlin @iGEM_HU]

This will be the most difficult step, but we have some very promising ideas!
#minicell #targettaxi #igemhuberlin #cancerresearch

[iGEM HU Berlin @iGEM_HU]

In the final step, our minicells bind specifically to tumor tissue and then inject proteins to inhibit the cancer cell growth. To do this, our minicells will form complexes on their outer shell that bind to specific surface structures of the cancer cells.

[iGEM HU Berlin @iGEM_HU]

https://t.co/xhuE2C2cBy

Our promotion video is now available on the official iGEM website! 🥳

[iGEM HU Berlin @iGEM_HU]

#minicellproduction #minicells #igemhuberlin #phase2 #cancercelladhesion #proteinsecretion

[iGEM HU Berlin @iGEM_HU]

Phase 2: Cancer cell adhesion & protein secretion.
The injectisome, a complex inherent to Salmonella, will be used for protein secretion. It has a secretion system and a needle-like structure that protrudes from the cell. The injectisome is also inherent in our minicells.

[iGEM HU Berlin @iGEM_HU]

Our minicells will form complexes on their outer envelope that bind specifically to these surface structures. This will be the most difficult step, but we found promising candidates!

[iGEM HU Berlin @iGEM_HU]

For further information you can have a look here: https://t.co/Wme0O4Huw1, and for visualization of the oscillation you can look here: https://t.co/XaP6EcycQp.
#minicells #igem #CancerResearch

[iGEM HU Berlin @iGEM_HU]

Some information to Phase 1:
We want to derive achromosomal minicells from our attenuated #Salmonella Typhimurium strain to use them as drug delivery system.
There are different approaches to yield bacterial minicells. We are using the disruption of the Min system.

[iGEM HU Berlin @iGEM_HU]

By deletion of the minD gene, cells are unable to restrict the divisome to mid-cell, leading to septum formation at cell poles and constriction of nucleoid-free minicells.

[iGEM HU Berlin @iGEM_HU]

We recently met virtually with @ubcigem from Vancouver, Canada, introduced each other to our teams with our projects, and then discussed possible ideas for collaboration. #igem #fightcancer #minicells

[iGEM HU Berlin @iGEM_HU]

Last week we met online with @igem_iiserb, another very motivated iGEM team from India, presented each other our projects and discussed about a collaboration. #igem2021 #collaboration #igemcollaboration #igemcollaborationmeetup #fightingcancer #fightingcancertogether

[iGEM HU Berlin @iGEM_HU]

Hi folks!
We want to start introducing you to our project. First of all, in a nutshell:
We aim to develop a system with minicells as vehicle for anti-cancerous peptides which will be secreted into specifically targeted tumor cells.
Stay tuned!
#iGEM #iGEM2021 #SynBio #HumboldtUni

[iGEM HU Berlin @iGEM_HU]

Happy to announce that we are participating in the #iGEM contest this year! With our #Salmonella-derived #minicells, we want to contribute to the fight against cancer. More information coming soon.
#iGEM2021 #ScienceTwitter #SynBio

[iGEM @iGEM]

We are recruiting new members for our judging leadership committees for 2021! Both committees work to improve the judging experience in iGEM for both judges and teams. More info can be found on each application: https://t.co/DqtqdVW6Mb https://t.co/keMaUsnYTE