Nepal has the greatest altitude variation on Earth:
🔺8,848m at Sagarmatha / Everest
🔻59m at Mukhiyapatti Musharniya, near Janakpur.
↕️ All within ~150km north-south.
No other country on Earth packs so much altitude drama into such a compact space. 🌍📷
Has anyone been to both? 👇
Abhishek Sharma on MS Dhoni’s captaincy in the IPL:
“When I walked out to bat in the IPL, Mahi bhai was right behind the stumps and Jaddu bhai was ready to bowl. I had a very clear plan in my mind — I would attack the left-arm spinner straight away, first or second ball, no matter what. But Dhoni is built different. From behind the wickets he made a small gesture, whispered something to Jadeja, and shifted a fielder just a few steps. And that was enough to shake me.
In that moment, I genuinely felt they had cooked up a special plan for me. The confidence I walked in with suddenly disappeared. I didn’t play the attacking shot I had prepared for, became cautious, and that hesitation stayed with me. Eventually, I got out to a fast bowler — and even today I remember that entire incident clearly. That is the psychological impact Dhoni creates without saying a word.”
@MikkhailVaswani@cricketaakash@OfficialNPLT20 So Happy for 2 of u. Thank you so much for coming to Nepal & making #NPL gracious. Still remember those days of #DialCForCricket on #NeoCricket. Mikkhail sir has given so much of love to Nepal Cricket & now I wish Aakash sir will do the same. Hope you're having a good time here❤️
Isotretinoin is a powerful oral retinoid (vitamin A derivative) mainly used for severe, treatment-resistant acne — especially nodulocystic or conglobate acne that hasn’t improved with antibiotics or topical therapy.
🔹 Main Indications
Severe nodulocystic acne
Acne with scarring or high risk of scarring
Acne causing significant psychological distress
Recalcitrant acne (failed ≥2 other therapies)
🔹 Mechanism of Action
It targets all major pathogenic factors of acne:
↓ Sebum production (shrinks sebaceous glands)
↓ P. acnes proliferation
↓ Inflammation
↓ Keratinization of follicles
🔹 Major Side Effects (high-yield for exams)
Teratogenicity (strict contraception required)
Dryness of lips, eyes, and skin (cheilitis, xerosis)
↑ Triglycerides and cholesterol
↑ Liver enzymes
Depression or mood changes (rare but monitored)
🔹 Key Notes
Pregnancy is absolute contraindication → mandatory iPLEDGE program (in the U.S.).
Must check LFTs and lipid panel before and during treatment.
Avoid vitamin A supplements (risk of toxicity).
Avoid tetracyclines (risk of pseudotumor cerebri).