J Fretz

Research Associate; Manager of the Orthopaedics and Rehabilitation Histology Laboratory at a Yale School of Medicine

[J Fretz @JAFretz]

https://t.co/olVN7RrP2R

[J Fretz @JAFretz]

Thank you to the @ECTS_soc for inving me to talk at #ECTS2025
I had a wonderful time getting to know so many of you and appreciate the opportunity to educate on the biology of CKD-MBD

[J Fretz @JAFretz]

This brings to mind the 3 month pase where my daughter would cry incessantly on car trips unless all conversations were sung to the tune of "Twinkle twinkle little star"
How did we figure this out? Desperation? Kids. LOL

[Yale School of Medicine @YaleMed]

Warm up those pipes, moms and dads: a Yale study finds #singing to your #infant can significantly improve the #baby's mood. https://t.co/WNoHQN8FWn

[Rajini Rao @madamscientist]

Pitt to pause PhD admissions, following Vanderbilt and USC, because of uncertainty of NIH funding to academic universities.

Who will teach and train US scientists for pharma and biotech? Should we import them from countries that do?

https://t.co/YkhmAyKNWV

[Cell Research @cell_res]

🧪Tau(t)ing glucocorticoid binding

The Highlight authored by Jan Tuckermann, which was published in Cell Research, discusses the recent breakthrough regarding glucocorticoid receptor.

Key insight:
Tau, rather than canonical GR, mediates GC-related adverse effects, particularly osteoporosis.

🔗Read more:
https://t.co/DzK11aUlPH
https://t.co/mPShS9ToHM

Thanks to the scientists for the exciting article and highlight! @ChuanjuL @JanTuckermann @YaleMed @Yale @uni_ulm

#CellResearch #Tau #Glucocorticoids #Osteoporosis #Endocrinology

[Cell Research @cell_res]

The January issue of Cell Research is now live!

This month’s issue identifies Tau, an infamous player in Alzheimer’s and other neurodegenerative diseases, as a low-affinity receptor for glucocorticoids, driving their side effects such as osteoporosis (GIO).

Discover 5 highlights, 1 review article, 3 articles, and 3 letters, including Wenyu Fu et al.’s work on pages 23-44.

https://t.co/w0mvxi2JPj

#Glucocortiocids #Tau #Osteoporosis #Research #OpenAccess

[J Fretz @JAFretz]

I am so appreciative and excited to be included in this project. It's the cover story for this month!
@ChuanjuL @OrthoAtYale @YaleMed

[Cell Research @cell_res]

Check out January’s cover story!

Tau, infamous for its role in Alzheimer’s and other neurodegenerative diseases, has now been identified as a low-affinity receptor for glucocorticoids, driving their side effects such as osteoporosis (GIO).

Explore the breakthrough in the field of glucocorticoids, endocrinology, and neuroscience studied by Wenyu Fu et al. (pp. 23-44).

https://t.co/mPShS9ToHM

#CellResearch #Tau #Glucocorticoids #Osteoporosis #Endocrinology

@YaleMed @Yale

[The Kusumbe Lab @Anjali_Kusumbe]

Bone marrow endothelial cells do not decline in aging 👇
https://t.co/Yru1QgM7Pu

How can VEGFR3 staining distinguished from Flt4-CreERT2 R26-mTmG mice signals
@NatureCellBio @NaturePortfolio

Tamoxifen & analysis timepoint
areas in diaphysis lack GFP but not VEGR3 staining

[J Fretz @JAFretz]

We really appreciate this commentary on our latest publication in Cell Research @NaturePortfolio @OrthoAtYale

https://t.co/5w6AO112IB

[J Fretz @JAFretz]

A new publication is a great way to start off 2025

https://t.co/YUzUC1vzxN

[J Fretz @JAFretz]

Diabetic Kidney Disease: Novel Treatment Approach May Help Prevent Fibrosis, Study Shows https://t.co/Axd8UJpTkj

[Vishal Mohanakrishnan @vishalmkrishnan]

Bone remodeling is traditionally driven by osteoblasts and osteoclasts, but our study reveals a third essential player: "Type R capillaries".

Excited to share my PhD work from @ralfhadams lab, now published in @NatureCellBio.

https://t.co/KMTIlSBnjl
🧵1/8👇 🐭🔬🦴

[JBMRPlus @JBMRPlus]

Findings in this #JBMRPlus article suggest that osteocytes potentially play a significant role in the post-traumatic systemic response to fracture, though the effects differ between trabecular and cortical bone @benosipov1 @OrrScience

Read more here: https://t.co/eipg5Dfzy3

[J Fretz @JAFretz]

That's my Representative. Thank you @rosadelauro for your words

[Ya'el Courtney, PhD @ScienceYael]

THANK YOU @rosadelauro for your words to NIH director @ today’s hearing:

"Your record .. is unparalleled in human history ... If we stop investigating infectious diseases, people will DIE! That needs to be said LOUDLY! and CLEARLY! in this environment."

https://t.co/AEISFW0Owr

[J Fretz @JAFretz]

What are we staining today? Some pretty osteoclasts (and a few osteocytes) with TRAP on FFPE sections
#histology #bone

[Scott Isaacs @scottisaacsmd]

One of the reasons why it is so difficult to maintain weight loss is because adipose issue retains an epigenetic memory of obesity after weight loss.
https://t.co/BvNcuLdhYB

[JBMRPlus @JBMRPlus]

New data in #JBMRPlus from a multicenter cohort demonstrated that sequential therapy from teriparatide to romosozumab exhibited greater benefits in increasing BMD at any site than romosozumab to teriparatide. #freetoread #openaccess @ASBMR

Read more here: https://t.co/rI7iOSyVfH

[J Fretz @JAFretz]

If doing your own plasic embedding is a bit intimidating (or something for which you aren't equipped) here is our histology core website:
https://t.co/VujZURX0si

[J Fretz @JAFretz]

It's live! New paper is out with our updated methodology for plastic embedding bones (small and large)

https://t.co/hSVkSVcTT0

#histology #boneresearch #hardtissue

@OrthoAtYale @YaleMed @ASBMR @ORSsociety

[J Fretz @JAFretz]

That feeling of placing the last slides of the group right as the clock ticks over to 5:00
@OrthoAtYale #histology #bone