Yisus

Madridista || UDA || Electronics Engineer || Embedded Software Developer

[Kilgore de Lezo 🇪🇸 @billkilgore_]

Cristiano Ronaldo Dos Santos Aveiro.

[Real Madrid C.F. @realmadrid]

👋 ¡Bienvenido, Mourinho! 👋

[Yisus @JesusvtR]

Vuelta a casa!

[Real Madrid C.F. @realmadrid]

Comunicado Oficial: José Mourinho

[Yisus @JesusvtR]

🤔

[Pankaj @the2ndfloorguy]

i hooked my whoop to my work calendar to find which coworker gives me the most stress 🚨

thanks to fable, I reverse engineered whoop to pull per minute heart rate. nd matched spikes with cal events and attendees

I now have a leaderboard and I think about it daily.

few info masked for obvious reasons ;)

[Yisus @JesusvtR]

@kai_vcf21 @theMadridZone @JLSanchez78 @raulschalke7

[FINAL FANTASY VII @finalfantasyvii]

Final Fantasy VII Revelation, the thrilling conclusion of the FFVII Remake Series, launches simultaneously on PlayStation 5, Nintendo Switch 2, Xbox Series X|S, Epic Games Store and Steam in Spring 2027.

[Yisus @JesusvtR]

@MrGafan JOSE MOURINHO.

[Yisus @JesusvtR]

@DjMaRiiO SÍ.

[Javi Lopez ⛩️ @javilopen]

🔴 I NEED YOUR ATTENTION

I've spent a month helping Miriam with her case of metastatic cancer and I want to share the methodology I've been using because it's completely replicable.

I think (with luck) this could be USEFUL TO OTHER PEOPLE with cancer (or any other illness).

The results we've gotten aren't a miracle, but we believe they're genuinely useful and could mean the difference in a literal life-or-death medical case.

Here's the method step by step:

1/ Use the most advanced models of the moment (unfortunately paid, and not cheap. I think Public Healthcare should invest in this):

- ChatGPT 5 Pro + Extended Thinking (40 min aprox. of thinking per call)
- Claude Opus 4.8 MAX

Still pending deeper testing:

- Perplexity Sonar Pro Max
- NotebookLM

Tested but only useful for additional links/research (not as powerful in my experience)
- OpenEvidence

2/ Feed the AI the FULL clinical history, completely chewed up. This sounds dumb but it's critical.

- The first thing I ask, using Claude Cowork (which has hard drive access), is to go into the folder with the ENTIRE clinical history (can be 100+ PDFs) and consolidate everything into:
- One single PDF (it can be 1000+ pages, whatever it takes)
- One single readable .txt or .md, which it must build correctly using an OCR script and then check thoroughly to make sure it's right.

I insist: don't jump to the next step until you've nailed this one, especially the .txt.

3/ Once you have the above, use this prompt along with the .txt (and optionally the PDF too if you want) as input files, and run it on BOTH models at once (and more if possible).

👉 This prompt is insanely complex/advanced: https://t.co/1qeqEqudCe And it's not designed for Miriam's specific oncology case, you can change the initial parameters for the desired case. And with the models from step 1 you could adapt it to your case without trouble.

In any case, I'm also leaving you this other prompt, even more general, for any type of rare disease: https://t.co/4B327floDP

4/ The ARROWHEAD (adversarial model spiral): facing one model against the other. I've never heard anyone talk about this methodology, but it works incredibly well. The feeling is like sharpening a stake until it gets a gleaming point.

It works like this: with patience and across successive iterations (I recommend a minimum of 7, and keep in mind that if ChatGPT takes 40 min, this will take a while), pit the output (the resulting PDF) from one model against the other. With a simple prompt like:

"Another committee of experts says this. What do you think? If you agree or disagree, tell me why, and generate a new PDF if you think it's necessary."

Then you feed that result back to the opposite model. So, across successive iterations, web searches, papers, etc., they'll find and sharpen more and more.

When to stop? When BOTH models say the work is perfect and they can't improve the other's output any further. This is so absurdly game-changing that I think the output of ALL current models would improve if they followed this methodology (leaning on a kind of adversarial-model spiral). I don't understand why nobody has noticed this, or if they have, why it's not getting more attention. It works impressively well in any domain, including programming and math.

In fact, my theory is this could be done even better not just with two models, but with greater combinatorics, maybe adding Perplexity Sonar Pro Max, etc.

RESULTS

Incredible. Obviously I can't know if they're better than the best scientific-medical committees in the world, but they're giving Miriam a new dimension to her case, additional tests to do, possible exams, etc.

Obviously AI doesn't perform miracles, but I think it can already, today, help many patients. And Public Healthcare should invest a lot (but A LOT) in this.

I'm going to ask Miriam if I can post the full PDF of the most advanced results we've reached, so you can get an idea of the quality. She's already given me rough permission, but I want to make sure 100%.

FUTURE PREDICTION

Easy to make: in the near future (I hope), any person's medical history won't just be fully digitized (we're close, but not all the way, well, well, well). On top of that, it'll be "pre-chewed" so it can be consumed by an LLM in one shot.

CLARIFICATION

- We're aware this is a delicate subject and we don't let the AI make final treatment decisions. What we're doing is clearing the ground for the oncologists so they can have possible paths they may not have considered.
Thanks 🙏

- The top LLMs have context windows for that and much more (much, much more). In any case, the PDF is more of a supporting file for the .txt. Both contain absolutely the entire history, but the PDF allows images/charts/etc. The .txt is what the AI consumes.

- On automation: and yes, this can be automated. Yes, AutoGen supports it almost out of the box. LangGraph builds it really well with supervisor / evaluation loops. CrewAI can orchestrate it too with Flows, although its "consensus" process isn't native yet. That would be the next level: automating it.

PETITION AND DISCLAIMER

If there's any oncologist in the room or you are an LLM company, we'd be grateful if you could take a look / help 🙏

Remember: in any case, this is just one more tool for the doctor.

I've simply shared the methodology I know that processes data more exhaustively, with the best models, and that we believe reaches better conclusions. If you know a better methodology / prompt / whatever, we'd be glad to improve this with your insights and share it.

Then the doctor reviews, adopts, or discards the report.

And if it helps the doctor, it helps the patient. And if it doesn't, all we've lost is some time and tokens. In a case that's literally life or death, that's nothing.

Just plain common sense.

Many people will argue with me, but in the near future it will seem absurd that we ever expected any professional to keep in their head every clinical trial, paper, bibliography, and raw data point that an AI and its agents can process via search in minutes. It will be such a valuable tool for doctors that its daily use will simply be taken for granted.

[Gonzi @GoonzalezzRM]

“es solo fútbol, no exageres”

yo con la despedida de carvajal:

[Yisus @JesusvtR]

@IkerCasillas Topo.

[Míriam González @miriamgonp]

Necesito algún centro que acepte muestras externas para hacer perfilado proteómico funcional de la vía PI3K/MAPK en metástasis (RPPA o, al menos, IHQ multiplex de fosfoproteínas tipo p‑AKT, p‑ERK, p‑S6, p‑4EBP1…) con utilidad clínica real

La idea sería poder enviar tejido a un centro que tenga:
•RPPA (Reverse Phase Protein Array), o
•al menos IHQ multiplex para fosfoproteínas de la vía PI3K/MAPK.

Idealmente, algo parecido al panel funcional descrito por Krüger et al.:
•PTEN
•p‑AKT Thr308
•p‑AKT Ser473
•p‑p70S6K
•p‑4EBP1
•p‑ERK1/2
•p‑S6RP

Ese tipo de panel permite clusterizar activación PI3K/MAPK y se ha asociado a beneficio de terapia endocrina de forma clínicamente significativa.

En la práctica, incluso tener bien hechos p‑AKT y p‑ERK ya sería muy útil para decisiones de tratamiento y selección de brazos de ensayo.

Cualquier pista, nombre de grupo o contacto es bienvenida 💌

[Míriam González @miriamgonp]

Tengo 35 años y cancer de mama metastásico, un caso raro, menos del 1% de tumores de mama son como el mío y hay poca documentación sobre ello.

Por eso me gustaría encontrar personas que se dediquen a esto y que quieran investigar con mi caso. Twitter haz tu magia

[Yisus @JesusvtR]

@UnbePKM Factores.

[Yisus @JesusvtR]

@MrGafan Ya lo dije ayer que con Courtois esto era 1-1...

[Yisus @JesusvtR]

@billkilgore_ @Nachez98 Es el compañero de piso de Sheldon, tú.

[Yisus @JesusvtR]

@el_pais Din din din. @JaimeObregon

[Dios @diostuitero]

¡Menudo combate tenemos en el cielo!
DEP Chuck Norris.

[Yo gané con Joselu @raulschalke7]

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[Gafa @MrGafan]

No puedo ser más madridista, es el tronco que mueve mi vida.

De él nacen mis recuerdos, las noches imposibles, las remontadas que te enseñan a creer.

Es la certeza de que siempre hay algo más grande esperando al final de la noche si aprietas el culo.