Joseph Secoges

Interventional Territory Manager: GE Healthcare - Board: Simon’s Heart. Wanna Be Racer: CS Velo Racing #PSUNittanyLion #GMCGriffin

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. I've held dying hearts in my hands in the cath lab at 3 AM. And I need to tell you something that changes everything about how we prevent heart attacks.

For decades, the entire field was built on one target: lower LDL cholesterol. Statins save lives — that's settled science. But too many of my patients did everything right — took their statins, hit their numbers, lived clean — and still ended up on my table with a ruptured artery.

We were treating the smoke while the fire kept burning.
The fire is inflammation. And the evidence is now overwhelming.

The CANTOS trial proved it first — lowering inflammation independent of cholesterol reduced cardiac events. But the newer data is what keeps me up at night.

AI-enhanced CT angiography can now detect inflamed arteries by measuring changes in the fat surrounding your coronary vessels — the perivascular fat attenuation index. Higher inflammation in the fat around even one artery independently predicts cardiac death. When multiple arteries show inflammation, the risk multiplies dramatically — even in patients whose cholesterol looks perfect.

This isn't theoretical. This is measurable. Right now. On a scan you can get this month.

Low-dose colchicine — a drug that's been around for centuries for gout — is now FDA-approved specifically for reducing cardiovascular events. It works by quieting the inflammatory cascade that destabilizes the plaque sitting in your arteries. A pill that costs pennies is saving lives the statins couldn't reach.

And the next wave is already in Phase 3 trials. Ziltivekimab — an IL-6 inhibitor — targets the central inflammatory pathway driving atherosclerosis. Phase 2 data showed a 90% reduction in hsCRP. The ZEUS cardiovascular outcomes trial is enrolling now, with results expected late 2026 into 2027. If positive, anti-inflammatory therapy will become standard in managing heart disease alongside lipid-lowering. The era of inflammation-targeted cardiology is arriving.
But it goes deeper than drugs. AI is now predicting heart failure and cardiac events 5+ years before symptoms — integrating CT imaging, electronic health records, and genetic data with accuracy that jumps far beyond traditional risk calculators.

And polygenic risk scores — a simple genetic test that flags inherited cardiovascular risk — are now formally recognized as a risk-enhancing factor in the 2026 ACC/AHA guidelines. A single blood draw can reveal risk that's been silently building since birth. Decades before the first chest pain.

Here's what this means for you right now — today:
Ask your doctor for a high-sensitivity CRP test. It's cheap, routine, and measures the systemic inflammation that standard cholesterol panels completely miss. You can have perfect LDL and inflamed arteries that are quietly preparing to rupture.
If your hsCRP is elevated, discuss low-dose colchicine with your physician. It's FDA-approved for exactly this.
Push for a coronary CT angiography with AI plaque and inflammation analysis if you have risk factors. This isn't the stress test your parents got. This is 3D visualization of your actual arteries — with AI quantifying not just how much plaque you have, but what kind it is and whether the surrounding tissue is inflamed.
Consider polygenic risk score testing — especially with a family history of early heart disease. It's now guideline-supported.

And the foundation that never changes: move daily, eat real food, sleep 7-9 hours, manage stress, and know your numbers — ApoB, Lp(a), hsCRP, fasting insulin.
I left Iran as a child with nothing. I rebuilt everything in a country that gave me the freedom to become a physician. I've spent twenty years watching patients get second chances.

The ones who haunt me aren't the ones who died on my table. They're the ones who survived but never acted on what the science was telling them — years before the event that didn't have to happen.

You can have perfect cholesterol and still have a heart attack. Inflammation plus genetics can drive plaque rupture in arteries that look "fine" on a standard panel.
The myth that normal cholesterol means you're safe has cost more lives than I can count.

We now have the tools to detect the fire — not just the smoke. AI to see it. Genetics to predict it. Drugs to quiet it. And the ancient basics — movement, real food, sleep, purpose — to prevent it from starting.

Prevention is the new cure. And the science to make it real is no longer coming.
It's here.

[Joseph Secoges @JosephSecoges]

@AaronSiriSG @ifihadastick So ridiculous. It’s all criminal

[Wafik S. El-Deiry, MD, PhD, FACP @weldeiry]

Here is my opening testimony at the US Senate Hearing chaired by Senator Ron Johnson “Plausible Mechanisms of COVID-19 Injections Causing Cancer and Attacks on Scientific Publications and Research,” on June 3, 2026.

https://t.co/mz2T71FA98

[Joseph Secoges @JosephSecoges]

@YaBoyCoots Omg what an awesome time

[Josh Reynolds @JoshReynolds24]

Regardless of your hockey team, this Stanley Cup Finals intro is absolutely unbelievable…

Ray Bourque interview, @TheKillers ‘All These Things That I’ve Done’ playing, Jon Hamm narrating… Just perfection. Made me tear up.

Extremely well done 👏🏽👏🏽

[Joseph Secoges @JosephSecoges]

@SMB_Attorney What a nightmare. More meds lol.. no thank you and your Pharma friends

[Mark Kaplan @markkaplan20]

Five diseases. One chart. 50 years.

Obesity up 1,000%.
Diabetes up 637%.
Alzheimer's up 500%.
Cancer up 216%.
Heart disease up 100%.

All rising. All together. All since 1975.

These are not five separate diseases. They are five symptoms of one disease.

A foodborne illness.

The food changed. The guidelines changed. Fat was replaced with sugar. Butter was replaced with seed oils. Real food was replaced with 10,000 chemicals your grandmother would not recognize.

And every one of these lines followed.

Your doctor treats them as five separate problems. Five specialists. Five prescriptions. Nobody connects the dots.

The root cause is metabolic. The science is clear. And the solution starts with what you eat, what you test, and what you stop believing.

https://t.co/rvX3X9MXkY

The truth heals

[Valerie Anne Smith @ValerieAnne1970]

Sen. Ron Johnson: “This is a PROFOUND revelation… The US FDA now admits COVID-19 vaccines KILLED American children.”

Healthy kids — virtually ZERO risk from COVID — were FORCED by Biden mandates into lethal shots.

Leaked FDA memo on child deaths: regulators confess their actions “we have harmed more children than we saved.”

They KNEW the risks. They HID the signals. They MANDATED the deaths anyway.

Mass murder by mandate. Where is the justice?

[Joseph Secoges @JosephSecoges]

@SNPittsburgh 😭😭😭😭😭😭waaaaahhhhh!!!! Just say your team is getting handled and stop crying

[al morganti @nufced]

They should run this video on the ceiling of the Sistine chapel.

[Joseph Secoges @JosephSecoges]

@HustleBitch_ You list all the ‘possible causes’ lol.. are you trying to distract from what everyone knows is the REAL cause?? Genetic modifying, immune system triggering vaccines ARE the biggest weapon on health in the history of humanity

[Joseph Secoges @JosephSecoges]

@GovernorShapiro This is really pathetic.. it’s all about money to spend, huh? What about health? Nope, guess it doesn’t fit your plans

[Joseph Secoges @JosephSecoges]

@MichaelAlbertMD @farkomd Big surprise.. another study that says more meds is the answer 🙄

[Joseph Secoges @JosephSecoges]

@OnwardState This can’t be real.

[Joseph Secoges @JosephSecoges]

@Hero_OfThe_Day @NBA Total garbage and it’s by design

[Joseph Secoges @JosephSecoges]

@captaindomi @dom_lucre How is it making his life easier?? lol. He is doing work that he wouldn’t have to do if the robot didn’t exist

[Joseph Secoges @JosephSecoges]

The entire bottled water industry is the biggest scam in the history of civilization. 99% municipal water that is put into cheap, toxic plastic and marketed as healthy, with 1200% markup. Your tap water is safer

[Bottled Water Facts @BWMatters]

“Alarmist and misleading.” That’s how water safety advocates describe the standards Oasis Health relies on. FDA rules ensure bottled water safety. But the app still pushes $636 water testing kits and $50 subscriptions.
More expert analysis here:

[Joseph Secoges @JosephSecoges]

@MikeSielski Pretty pathetic take

[Joseph Secoges @JosephSecoges]

@BizNasty2point0 @alexwalsh6 Watch it, Paul. He’ll call a couple fat guys to chase you out of a bar again. 😂 still can’t believe a pro hockey player ran like a girl like that

[Joseph Secoges @JosephSecoges]

@greg_price11 @grok who is the judge that reduced this shooters previous jail sentence?