Dive into the intricate connections in the mouse brain! 🧠✨
This video shows reconstructed neurons projecting from the thalamus to various regions of the cortex. Each neuron was fluorescently labeled and imaged with our cutting-edge ExA-SPIM microscope.
New Neuron Types Discovered in Brainstem’s Sound Processing Center
Researchers have identified and mapped diverse cell types in the cochlear nucleus, a crucial brainstem region that processes auditory information, enabling us to understand speech, music, and other sounds.
By using advanced techniques like single-nucleus RNA sequencing and Patch-seq, the study revealed previously unknown neuron subtypes and validated the roles of known cell types.
These cells perform specialized tasks, such as detecting sudden noises or changes in pitch, which are essential for auditory processing.
Understanding these distinctions lays the groundwork for developing targeted therapies for hearing disorders, especially for individuals for whom cochlear implants are not viable.
The findings also challenge established principles of auditory science and open new pathways for therapeutic exploration.
The comprehensive cellular and molecular atlas created in this study offers tools for further research into sensory processing in the brain.
Excited to publish this work by Junzhan Jing and colleagues from our lab @bcm_neurosci and the collaborators in Nature Communication:https://t.co/LkXBkJQBrb
New breakthrough in glioma research!
In an exciting collaboration among labs at Baylor College of Medicine, they have uncovered a new cell type in human brain tumors.
A major leap forward in glioma biology! Read about it here: https://t.co/iVYM1w17Pg
✨🔬 Meet ExA-SPIM, a revolutionary new microscope and tissue processing combo developed at the Allen Institute for Neural Dynamics that is showing scientists the brain as it’s never been seen before.
In this work, we used Patch-seq to relate each molecularly distinct cell type to well-established cell type in the mouse cochlear nucleus. Hope this work can open a new window for genetic dissection of auditory processing and hearing disorders.
https://t.co/ZtLwVNIdYL
Very excited to share our latest work about multi-modal cell typing in the cochlear nucleus, the first station for all central auditory processing.....https://t.co/MgUpXkDdUd
Being in neuroscience for more than 15 years, but still a freshman in auditory research. I’m very glad to be here @AROMWM for the first time with my poster. It’s really a pleasure to have lots of new friends to stop by my work. Really appreciated that!
We oppose & urge greater clarity re: Presidential Proclamation on Suspension of Entry as Nonimmigrants of Certain Statuses & Researchers from China. We stand in solidarity with our students, trainees & all, no matter the nationality, race, gender, sexual orientation & religion!
Congratulations to Dr. Xiaolong Jiang & collaborators on receiving R01 grant funding! The goal of the proposed research is to define the building blocks (morphological, electrophysiological and transcriptome) of monkey prefrontal cortex and dissect its local circuit organization.