KALLEL 🐢

KALLEL is a non-profit longevity foundation that supports aging studies and clinical trials to extend human lifespan & healthspan.

[Rand @rand_longevity]

Longevity news this month:

• semaglutide extended lifespan ~12% in old female mice
• an AI-designed drug nudged 6 aging clocks younger in a lung disease trial
• google mapped every possible single-letter DNA change

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Telomerase expression and activity in the immortal cnidarian Hydra

"Our data suggest that telomerase may play a role in the immortality of Hydra."

https://t.co/EyHKUygDfc

[Nature Biotechnology @NatureBiotech]

Photolabile oligonucleotides with topological light gradients enable spatially resolved single-cell transcriptomics and epigenomics https://t.co/W8btQm4ToQ

[Julian Issa @juliankissa]

Dr. @misraetel's case for why age reversal will reach everyone, fast: Old people run the world.

They run corporations and governments, and none of them want to die.

So when age reversal therapies hit trials, they'll fund them, not block them. And once they have it, keeping it from everyone else becomes politically impossible.

[Sergio Ferrero @calotonterias]

Las personas que caminan rápido tienen un cociente intelectual promedio 16 puntos superior al de las que caminan lento, sus caras parecen más jovenes y sus cerebros tienden a ser más grandes.

Aunque sabemos que la actividad física mejora el cerebro y el aspecto físico, y eso podría explicar parte de la asociación, a su vez ésta también puede deberse, sobre todo en el caso del IQ, a causas innatas: una mejor calidad biológica de base puede estar causando más velocidad al caminar, mejor funcionamiento cerebral y una cara más joven.

[News from Science @NewsfromScience]

The National Institutes of Health has unveiled a new tool meant to help biomedical researchers search the scientific literature and learn whether a finding has been replicated by other groups. https://t.co/6y1a8RsGKN

[Science Magazine @ScienceMagazine]

An AI model called RADAR, designed to provide broad diagnostic interpretation of abdominal CT scans, substantially outperformed existing AI systems across a wide range of diseases and clinical settings, researchers report in Science.

The findings demonstrate the potential of vision–language models to advance expert-level generalist AI tools for radiology. https://t.co/gSVD3JZ9xO

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Grip strength as a systems biomarker of aging: neuromuscular junction constraints and biomarker decoupling in gene therapy

https://t.co/AqgGbpxs1T

[Siim Land @siimland]

Green tea is one of the healthiest beverages in the world
- improves cardiovascular disease risk factors
- improves heart health
- improves metabolic health markers
- targets all hallmarks of aging
- reduces visceral fat
- is associated with lower mortality

Full thread on green tea benefits⬇️⬇️

Graph from: DOI:10.20944/preprints202309.0582.v1

[nature @Nature]

Artificial-intelligence systems can generate hypotheses, design experiments and analyse data — but humans still need to decide what makes sense

https://t.co/osGDoX1HSN

[Nathaniel David @NathanielEDavid]

1/
Do you carry ApoE4? About 1 in 4 ppl do. 1 copy: ~3X Alzheimer's risk. 2 copies: ~10X.

On Sept 21, Europe approved obicetrapib, a cholesterol drug that, in a large trial, lowered multiple AD markers in ApoE4 carriers.

Yes, a drug engineered to prevent heart attacks seems to lower AD biomarkers.

Read on for details.

[The Eagle flies free @Fa21519230]

🚨🚨 El Dr. David Sinclair acaba de revelar uno de los estudios más grandes sobre la nattokinasa...
Un estudio chino exhaustivo de 1.067 personas encontró que la nattokinasa revirtió la enfermedad cardiovascular al eliminar hasta el 95% de la placa arterial en un año...
Este suplemento es una enzima de la soja fermentada y cuesta casi nada...
Sinclair lo ha estado tomando diariamente durante un par de años...
Mide su arteria carótida con ultrasonido y dice que no hay acumulación de placa en absoluto.
Peter Diamandis también lo toma.
Él cree que necesitas al menos 6.000 unidades fibrinolíticas por día para obtener los beneficios...
• Las estatinas cuestan cientos por mes y vienen con efectos secundarios.
• Las intervenciones quirúrgicas pueden costar miles de dólares
La nattokinasa cuesta una fracción de ambas...
La advertencia de Sinclair: "Haz esto con el conocimiento de tu médico"...

[SciTech Era @SciTechera]

AGING IS MORE REVERSIBLE THAN WE THINK

A new study just gave us a fascinating clue. It hints that biological age may be more of a dynamic state than a fixed number.👀

Actually, researchers transplanted old hearts into young mice.

The old hearts didn't simply remain molecularly old.

Over time, their DNA methylation and gene-expression patterns shifted toward those of younger hearts.

And the reverse happened too.👀

But young hearts placed into older animals started showing older molecular signatures.

That means the environment surrounding an organ can actually influence its biological age.

And honestly, this is the part that gets me excited about longevity.

Aging isn't just a one-way accumulation of damage. it is a biological state that can be changed.

“A tissue's biological age isn't completely fixed.”

If we can discover the signals that push tissues toward aging, we may eventually learn how to block them, restore youthful states, and preserve function for much longer.

And future of anti-aging won't be about replacing old organs. It will be about changing the biological environment that makes them old.

read more:
https://t.co/iL3ig9kAIr

[LongevityLab @LxngevityLab]

Your cardio fitness predicts how long you'll live better than your cholesterol, blood pressure, or your genes (and low fitness is deadlier than smoking).

Here's what it means and how to raise it:

In a study of 122,000 people (Mandsager, JAMA 2018), the fittest had an 80% lower risk of death than the least fit.

Low fitness carried a higher risk of dying than smoking, diabetes, or heart disease. It's the single strongest longevity marker there is.

The number is your VO2 max, the top amount of oxygen your body can use during hard effort.

The higher it is, the stronger your heart, lungs, and muscles are working together, which is why it tracks so closely with how long you live.

Test it roughly by how winded you get.

If a brisk hill or a flight of stairs leaves you gasping, your VO2 max is low. If you can hold a conversation through moderate effort, you're in a good range. A watch estimate gets you a real number.

Build it with two things.

Easy zone 2 cardio a few times a week grows your aerobic base, and one weekly session of short hard intervals raises the ceiling.

Nothing lifts your VO2 max faster than 4 minutes hard, 3 minutes easy, repeated 4 times.

VO2 max is trainable at any age, and every step up drops your risk of dying by 13 to 15%.

Train your heart like your life depends on it, because the data says it does.

[Science Magazine @ScienceMagazine]

A psychedelic compound best known for its effects on the brain may help prevent one of chemotherapy's most debilitating side effects—chemotherapy-induced peripheral neuropathy, researchers report in Science.

In mouse models, as few as two doses of psilocybin given before treatment durably prevented CIPN through multiple cycles of chemotherapy, while preserving both nerve function and the therapies’ tumor-killing effects.

📄: https://t.co/rGxIJQdVVU
#SciencePerspective: https://t.co/UX1kCc3tWe

[HHMI @hhmi_science]

Our bodies create ~330 billion new cells every day through cell division. #HHMIInvestigator Andy Moore at our Janelia Research Campus captured that process in stunning detail — a feat that earned him 4th in the '26 @NikonSmallWorld in Motion Competition: https://t.co/UeI2GSTrG6

[Aging Science News @AgingBiology]

Mitochondrial Transplantation Rejuvenates Aging Heart by Restoring Mitophagy Flux via the HIF-3α-BNIP3 Axis
https://t.co/TcLfSfPODt

[Eric Topol @EricTopol]

There's been steady progress using organs in a dish—organoids— for medical research. But now there's the immunoid to enhance our understanding of the complex immune system in people, and at the individual level. @CellStemCell .
https://t.co/OockgXIcqA

[Longevity Technology @LongevityTech]

New patent covers combining hTERT and Follistatin-344 to target telomere length, muscle mass and blood-glucose levels in age-related disease.

https://t.co/CtJNYF3mHE

#longevity #geroscience #hTERT #Follistatin344 #telomeres

[Nicholas Fabiano, MD @NTFabiano]

Every workout lets your muscles talk to the brain to improve neuroplasticity, memory and mood.

The gym bros were right.