Associate Professor, Nephrology at JNMC and AVBRH,Wardha
Glomerular disease/Critical Care Nephrology/Transplant Immunology
#Onconephrology
DM Nephrology @JIPMER
This biopsy was taken from an older adult man with acute kidney injury and non-nephrotic range proteinuria. His medical history included metastatic colonic adenocarcinoma, for which he was taking bevacizumab, an anti-vascular endothelial growth factor (anti-VEGF) inhibitor. The sampled glomeruli show changes of thrombotic microangiopathy (TMA), including double contour formation of glomerular capillaries (Fig. 1) and intracapillary red blood cell fragmentation (Fig. 2). TMA is one of the most common adverse effects in the kidney of bevacizumab therapy, and it has been reported as early as one week after starting the drug. Other pathologies reported in the setting of anti-VEGF treatment include focal segmental glomerulosclerosis (FSGS), collapsing glomerulopathy, and immune complex-mediated proliferative glomerulonephritis, among others.
Reference
Usui J, et al. Clinicopathological spectrum of kidney diseases in cancer patients treated with vascular endothelial growth factor inhibitors: a report of 5 cases and review of literature. Hum Pathol. 2014 Sep;45(9):1918-27. Review. PubMed PMID: 25087655.
#TeachingPoints #kidneypath #renal #pathology
Rare intraluminal fibrin aggregates (PAS stain), along with background glomerular congestion (H&E stain). These findings can be subtle and raise concern for underlying renal vein thrombosis (RVT), a known complication of nephrotic syndrome, particularly in membranous nephropathy.
#renalpathology #renal #pathx #nephx #underthescope
HDFC Bank @HDFC_Bank@HDFCBank_Cares
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Calling from different numbers for loan
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HDFC Bank @HDFC_Bank@HDFCBank_Cares
This person is claiming to be your employee and sending such messages
Calling from different numbers for loan
Kindly take appropriate action
Recommendations for Pre-Analytical Urine Sample Handling To Allow Optimal Assessment of Albuminuria and Proteinuria
A consensus report of the USA NKF Albuminuria – Proteinuria Workshop
🔓https://t.co/NrxP0lKXaa
Current guidelines suggest moving away from "blanket fear" toward individualized care- focus on avoiding hypovolemia and optimizing dose. Learn more from this #Kidney360 review. https://t.co/h408v0qt2M
A 55 year old female underwent Deceased donor renal transplant at our centre with a cold Ischemia time of 6 hours. She had severe tricuspid regurgitation pre transplant. CIT was 6 hours. Output was reduced in the initial 6 hours which subsequently increased 1/n
She was initiated on Diuretics and fluid restriction . She responded with increasing urine output and gradually reducing serum creatinine and was discharged after 3 days with a serum creatinine of 0.9mg/dl
Final diagnosis - Acute cardiorenal syndrome in Kidney allograft !