South Korean researchers have developed a biodegradable patch or gel that can stimulate teeth to naturally regenerate dentin—the hard layer beneath enamel. After the dentist cleans the cavity, the patch is placed directly onto the tooth. Its bioactive molecules, including peptides, activate stem cells inside the pulp, prompting them to rebuild the lost dentin. This method could treat early decay without drilling, reduce the need for fillings, lower inflammation risk, and preserve more natural tooth structure. The technology is still in preclinical trial
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