KlenermanLab

Our research group develops single-molecule methods to address important biological issues, from neurodegenerative disease to how immune responses are triggered

[Elizabeth ‘Lizzie’ English @e_a_english]

🚨 NEW PAPER ALERT

'Detecting alpha-synuclein aggregates with small molecules on single-molecule array': https://t.co/gUPW5ZJxrP

Excited to share this @KlenermanLab & Hunter Lab @ChemCambridge collaboration. 1/🧵

[KlenermanLab @KlenermanLab]

➡️ Read our new paper here: https://t.co/Gs18YXF6NU

[UK Dementia Research Institute @UKDRI]

🧠 Lecanemab prefers to bind to a certain size of toxic protein found in people with early-stage Alzheimer’s, new research by @KlenermanLab & Prof Bart De Strooper reveals.

The study provides vital new insight into how different anti-amyloid drugs work👉https://t.co/eZD7JRYdu5

[The Science of Parkinson's @ScienceofPD]

Wow! First session at #ADPD2025 & Florence Layburn
@FlorenceLayburn from the @KlenermanLab is sharing new data using their new SIMPull method to look at the detection of soluble Tau aggregates in #Parkinsons. Very impressive presentation from this young PhD student!

[Arpan Dey, PhD @via_ADs_lens]

Witnessing an unforgettable moment when Prof Sir David Klenerman @KlenermanLab and Prof Sir Shankar Balasubhramaniam took us all through a journey of a few decades. The ups and downs, the importance of socialization, and most importantly the power of simple ideas -(1/2)

[Kei Cho Lab @ChoLab_Synapse]

What a wonderful talk!! Dorothea Boeken (@KlenermanLab) @Cambridge_Uni, advanced single molecule-super resolution Tau image assay. UNVEILING THE MOLECULAR LANDSCAPE OF TAU AGGREGATES IN ALZHEIMER’S DISEASE AND OTHER TAUOPATHIES. @UKDRI #ADPD2025 @adpdnet 🎉

[Elizabeth ‘Lizzie’ English @e_a_english]

@KlenermanLab out in force @adpdnet #ADPD2025 🇦🇹

Look out for talks from Beatrix & Dorothea tomorrow 👀

[KlenermanLab @KlenermanLab]

🗣️ Beatrix Huissoon, PhD student, on TNFa effects on aggregation in cerebral organoids
🗓️ Fri 4
🕗 5:20 pm
🧫 Session: Disease mechanisms
📍 Hall C

[KlenermanLab @KlenermanLab]

🇦🇹 At #ADPD2025?

Talks and posters on single-molecule aggregation to look out for from @KlenermanLab (@UKDRI @ChemCambridge)🧵⬇️

[KlenermanLab @KlenermanLab]

🗣️ Dorothea Boeken (@DorotheaBoeken), PhD student, on tau in Alzheimer’s disease and other tauopathies
🗓️ Fri 4
🕗 2:40 pm
🧫 Session: Tau aggregation
📍 Hall F1

[Cell Chemical Biology @CellChemBiol]

SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-res microscopy by @shekhar7_kedia, Emre Fertan, @JohnDanial15, David Klenerman @KlenermanLab et al at @Cambridge_Uni @ucl @univofstandrews https://t.co/8QzsAODEOT

[UK Dementia Research Institute @UKDRI]

Scientists led by @KlenermanLab have developed a new biomarker to measure brain inflammation in Alzheimer's & Parkinson's 🧠 👏 It could improve diagnostics and help test new therapies in clinical trials: 👉 https://t.co/aMbC7HITcO

[The Science of Parkinson's @ScienceofPD]

Interesting: @KlenermanLab et al establish an ultra-sensitive single-molecule pull-down immunoassay combined with dSTORM microscopy assayed human post-mortem brain, serum & CSF of #Parkinsons, #Alzheimers & elderly individuals for inflammasome ASC specks
https://t.co/VO2O7gYsDf

[The Science of Parkinson's @ScienceofPD]

A new pilot study from @KlenermanLab et al tested an antibody-based single-molecule pulldown assay to quantify salivary α-synuclein & amyloid-β peptide aggregate numbers (#Parkinsons & #Alzhiemers); Saliva aggregates retain relevant structural information
https://t.co/hTD5oLEp5c

[KlenermanLab @KlenermanLab]

Different Viewpoints: The David Klenerman and Shankar Balasubramanian Story 🧬

https://t.co/3fHwAq6Uhv via @InventorsHOF

[Inventors HOF @InventorsHOF]

Just a few weeks until the National Inventors Hall of Fame® Induction Ceremony! Take another look at this year’s class of Inductees before the big event on May 9. https://t.co/Md0tAoeWlt #NIHF2024

[Inventors HOF @InventorsHOF]

In just 10 years, 2024 Inductee David Klenerman & co-inventor Shankar Balasubramanian transformed a concept on paper into pioneering the Sequencing-by-Synthesis method for #DNA sequencing. Explore the remarkable journey of this newest Inductee! #NIHF2024 https://t.co/Wku6OhfT3k

[Inventors HOF @InventorsHOF]

Having a lifelong affinity for science, #NIHF2024 Inductee David Klenerman pursued chemistry @Cambridge_Uni, graduating with a bachelor’s degree in 1982. Returning in 1994, he currently serves as a professor of biophysical chemistry & is a group leader at the @UKDRI.