Kristoffer Berg Hansen

MD, PhD-student at @AUHCardio | #Ketones in Heart Failure and Metabolism | Cardiogenic Shock & Invasive Hemodynamics | Proud father | 🇳🇴🇩🇰

[Kristoffer Berg Hansen @KrisBergHansen]

Delighted to share our recent paper in @JACCJournals #JACCHF

In patients with #Cardiogenicshock, treatment with #ketone ester was associated with favorable hemodynamic effects 🫀⚡️

@GNigopan
@K_Hylleberg
@steffen_chr

➡️Editorial by Lopaschuk & Karwi

https://t.co/BjUU5Gbt8A

[Oskar Hørsdal @OHorsdal]

Our new study maps the hyperacute phase of ischemic cardiogenic shock in pigs: rapid loss of forward flow, early vasoconstriction, metabolic disturbance & mitochondrial dysfunction. Opens doors to early & mito‐targeted therapies! 🚀

https://t.co/LpPPLcDc7I

[Asger Granfeldt @AsgerGranfeldt]

Great work by @PeterCaroeeLind - even small changes in potassium is associated with increased risk of in-hospital cardiac arrest

Potassium Levels and In-Hospital Cardiac Arrest: A Matched... : Critical Care Medicine https://t.co/MqcU28dDGz

[Oskar Hørsdal @OHorsdal]

Now published in @BasicResCardiol 📑🚀
Infusion with #ketones improves hemodynamics and preserves mitochondrial and contractile function and in ischemic #cardiogenicshock 🐷🫀

https://t.co/7ssNZZAxSQ

[Protect Kamala Harris ✊ @DisavowTrump20]

🚨NEW: The Trump Administration has destroyed a mural of Dr. Anthony Fauci at the NIH Headquarters. The painting was there to honor his work to combat infectious diseases and inspire other health officials.

RETWEET if you stand with Dr. Fauci against the Trump Administration!

[Oskar Hørsdal @OHorsdal]

Exciting experimental data from Alexander and Lasse from @AUHCardio presented today at @escardio #ACVC2025 🫀

Ketone body 3-hydroxybutyrate may improve hemodynamics in #pulmonaryembolism

Short chain fatty acid butyrate increases CO in healthy pigs (⬇️)
https://t.co/ObiP7bg5cL

[Oskar Hørsdal @OHorsdal]

@KrisBergHansen from @AUHCardio presenting data on metabolic profiling as predictor of mortality and neurological outcomes in out-of-hospital cardiac arrest patients at #ACVC2025

Published data below ⬇️⬇️

https://t.co/XM7IawoFnr

[Oskar Hørsdal @OHorsdal]

Proud to present the hemodynamic effects of lactate infusion in #cardiogenicshock at @escardio #ACVC2025: Increased CO due to increased SV, enhanced ventriculo-arterial coupling and improved mitochondrial function 🫀

Full article published in @Crit_Care
https://t.co/FZ5avitxGf

[Kristoffer Berg Hansen @KrisBergHansen]

We recently tested the hemodynamic effects of another monocarboxylate, butyrate, with similar molecular structure and function as #ketone bodies 🫀

@CasperHomilius @MoeslundNiels @GNigopan @OHorsdal @jacob_seefeldt

https://t.co/x0eCTQqTJA

[Kristoffer Berg Hansen @KrisBergHansen]

@AsgerGranfeldt @GNigopan @NikolajRittig @AUHCardio @AsgerGranfeldt this is a good question. We would expect a dose-response relationship, as with ketones, however, there are probably concentrations at which the effect no longer is prominent.

[Kristoffer Berg Hansen @KrisBergHansen]

Is #lactate friend or foe?
Proud to share our data on the cardiovascular effects of lactate infusion 🫀 Looks a lot like the effects of #ketone infusion? 🤔

@GNigopan @NikolajRittig @AUHCardio

https://t.co/fu2U9IEzbu

[Florian A. Wenzl @wenzl_florian]

#Biomarkers refine the #personalized management of cardiogenic #shock.

🔥 New state-of-the-art review led by @VGalusko and @ESCWGThrombosis

👉🏻 https://t.co/714uPPyI1S

@TomLuscher @VPanoulas @CVandenbriele @ESC_Journals @KingsCollegeLon @RBandH @escardio #CardioTwitter

[JAHA @JAHA_AHA]

1,3‐butanediol improves cardiac function in heart failure patients, offering potential for sustained ketosis therapy. #AHAJournals @HalvorOG @GNigopan @K_Hylleberg @OHorsdal @KrisBergHansen @AUHCardio https://t.co/yElwqP5qyG

[Kristoffer Berg Hansen @KrisBergHansen]

@ChrStaehr @_JCBFM Congratz @ChrStaehr and team! Impressive! 👏

[Christian Staehr @ChrStaehr]

Thrilled to share our new study published in @_JCBFM (https://t.co/9lsDXXoru3)! We show that targeting Na,K-ATPase-dependent Src kinase activation can prevent 🧠 hypoperfusion and exaggerated NVC in a an awake mouse model of familial hemiplegic #migraine.
Here’s a short 🧵

[Asger Granfeldt @AsgerGranfeldt]

This was a tough one. 40000 abstracts screened. Limited evidence for the use of calcium for Hyperkalaemia

Pharmacological Interventions for the Acute Treatment of Hyperkalaemia: A Systematic Review and Meta-analysis - Resuscitation https://t.co/9bFi2M3MVP

@LarsWAndersen1

[Halvor Guldbrandsen @HalvorOG]

In HFrEF patients, exogenous ketone body therapy improves cardiac function. But they have a short half life.

Here we show prolonged ketosis and cardiac benefit with 1,3-butanediol in HFrEF patients🫀❤️‍🔥

@KrisBergHansen @OHorsdal @GNigopan
https://t.co/Ki91t9ksCj

[Kristoffer Berg Hansen @KrisBergHansen]

https://t.co/GrEq5o0uEq

[Kristoffer Berg Hansen @KrisBergHansen]

Happy holidays 🍾

Proud to share our recent publications on the neurohormonal effects of #ketone ester treatment and the cardiovascular effects of the novel ketone compound 1,3-butanediol in #heartfailure

@HalvorOG @GNigopan @OHorsdal @NikolajRittig

https://t.co/hlRdNBg5hB

[Peder L. Myhre MD, PhD @pmyhre]

Thrilled to announce that we have received ~2mill EUR from @helse_og_omsorg to conduct the STRONG@HOME trial at 7 sites in 🇳🇴🎉.

Building on #STRONGHF, this trial will test efficacy and safety of rapid uptitration of #GDMT after HF hosp can be performed by digital follow-up 📲

[Kristoffer Berg Hansen @KrisBergHansen]

In patients with #cardiogenicshock 🫀worsening global longitudinal #strain #GLS associates with poor outcomes and surpasses conventional #echofirst parameters in prognostic value ☠️ #jacobjentzer ⁦@JaeKOh2⁩ https://t.co/RqMz4SuwOJ