Kévin Macé

Postdoctoral Research Scientist at Birkbeck, University of London in structural biology

[Cascales Lab @CascalesLab]

Extension of the deadline for latecomers. Register to the Secretion Days in Marseille !

📅 Secretion Days 2026: October 8-9 in Marseille 🌊
🎤Invited speaker : Wilbert Bitter; @wilbertbitter
🆓 Free !
📥 Register here:
https://t.co/UtXJO2dnIZ

[Cascales Lab @CascalesLab]

Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
https://t.co/9Wo4R9UawC

[Cascales Lab @CascalesLab]

We have an Open position !! Either at the Engineer or post-doctoral level, to work on filamentous phages.
Collaboration between @l_houot and @doan_thierry

To apply at the E level:
https://t.co/i9XaaIrmUT

To apply at the post-doc level:
https://t.co/3xhVIRcDkF

[NatureStructMolBiol @NatureSMB]

New online! Computational design of sequence-specific DNA-binding proteins https://t.co/8dMUtDhPep

[Jun Liu Lab @JunLiuLab]

Exciting findings from @JunLiuLab #postdoc @YueJianUSTC @YaleMed Architecture and activation of the Legionella Dot/Icm type IVB secretion machine #cryoEM #cryoET #Legionella https://t.co/V8yXpXBomY

[Petya Krasteva @krastevalab]

Fellow ladies in science, as part of the disappearing species of international female scientists in France and perhaps every/elsewhere, I want to bring your attention to our institute's open call for group leaders 👩‍🔬🦠🧪🔬🤓!!! Come join me in doing some coolicious science here!

[Charlotte Michaux @CMichaux13]

Interested by applying to a MSCA fellowship in Rennes? https://t.co/3pNi7wDKa5

[Cascales Lab @CascalesLab]

Le LISM (https://t.co/LKcvRKEeez) propose une mobilité NOEMI pour travailler sur des assemblages de l'enveloppe bactérienne. Profil microbiologie, bio mol, avec une envie de faire de la biochimie, de la microscopie ou de la bio cell ! Rejoignez une unité dynamique !!

[Tiago Costa @CostaT_Lab]

With @jrpenades, we challenged AI co-scientist @GoogleAI to generate hypotheses. In just 2 days, it recapitulated our unpublished, experimentally confirmed mechanism for how cf-PICIs spread between bacterial species! 🤯 @imperialcollege @FlemingCentre

https://t.co/hXkZZco6vu

[Tiago Costa @CostaT_Lab]

New work from the lab with @jrpenades! We discovered a biological entity that spreads among different bacterial species by hijacking tails from various phages. This finding has major translational applications due to its broad host range. More news soon! https://t.co/z60xAsKXI7

[Biology+AI Daily @BiologyAIDaily]

PPIFold: a tool for analysis of Protein-Protein Interaction from AlphaPulldown

1. PPIFold is a novel tool that simplifies the analysis of protein-protein interactions (PPIs) by automating pre- and post-processing steps. It integrates with the AlphaPulldown package to make PPI predictions more accessible and efficient for researchers.

2. A key innovation is the introduction of the iQ-score, a composite metric combining multiple interaction scores (pi-score, iptm/ptm, and pDockQ) for more reliable PPI predictions. This scoring system reduces false positives, providing higher confidence in predicted interactions.

3. PPIFold optimizes computational workflows by separating feature generation (CPU-based) from model generation (GPU-dependent), preventing out-of-memory errors and streamlining large-scale PPI analysis.

4. The pipeline generates detailed visual outputs, including distograms, heatmaps, residue interaction tables, and interaction network figures. These outputs facilitate hypothesis generation and experimental design.

5. PPIFold's capabilities were validated using the bacterial Type 4 Secretion System (T4SS), demonstrating high accuracy against cryo-EM data and offering a comprehensive view of the system's interactome.

6. Designed for flexibility, PPIFold supports future updates to prediction software like AlphaFold3, ensuring its utility for cutting-edge structural biology research.

💻Code: https://t.co/QM2nOf8SCJ
📜Paper: https://t.co/U4TLJD5htL

#ProteinDesign #AlphaFold #Bioinformatics #StructuralBiology #MachineLearning

[Cascales Lab @CascalesLab]

We have an open PhD position to work on bacterial secretion systems. Please RT or apply through the CNRS job portal:
https://t.co/HxX23Od1oa

[bioRxiv Microbiology @biorxiv_micrbio]

Cryo-EM Structure of the relaxosome, a complex essential for bacterial mating and the spread of antibiotic resistance genes https://t.co/vE0JzjpvTd #biorxiv_micrbio

[bioRxiv Microbiology @biorxiv_micrbio]

Developing Biosensors for Specific Assessment of Trans-translation in Pseudomonas aeruginosa. https://t.co/XAdTkxeg4Z #biorxiv_micrbio

[Aravindan Ilangovan @ilango_aravind]

Two @wellcometrust funded structural biology Post Doc positions are available in my lab to study bacterial nucleoprotein complexes, in collaboration with @heathmurraylab. Please RT.

https://t.co/YYPzsm9YgM

[Kévin Macé @KvinMac1]

@LaurentTerradot Thanks @LaurentTerradot