CASL_lab

We are a team of highly skilled organic chemists with long-standing expertise in medicinal chemistry, total synthesis as well as custom synthesis.

[Chin-Soon Phan @chinsoonphan]

We discovered two P450 enzymes AscB/MmsB, catalyze a Tyr-C3-Trp-N1 cross-link and hydroxylation at Trp-C5 in the YxWxH motif. Interestingly, only AscB can catalyze additional Trp-C4-His-Nτ, generating a fused cyclophane RiPPs | Organic Letters
https://t.co/ZbXazWYzGA

[CASL_lab @LabCasl]

Today, Carlos is finishing his research exchange at LIOS. We had a great time collaborating on new TPP riboswitch ligands 🔬🤝within project #ESfondi #LZP #PostdocLatvia #PostdocLatvija. Nr.1.1.1.9/LZP/1/24/010 "Jauni TPP riboslēdža ligandi kā potenciālas antibiotikas" ✨

[CASL_lab @LabCasl]

A great day in the lab for #ShadowDays2026! 🧪✨#ESfondi, #LZP #PostDoc #Pecdoktorantura #PostdocLatvia #PostdocLatvija #FLPP

[CASL_lab @LabCasl]

Excited to present our latest results on Antibody-drug conjugate warheads at ADC London 2026 #RRF project No.5.2.1.1.i.0/2/24/I/CFLA/001

[CASL_lab @LabCasl]

Six months of work in one small envelope — the first compound library prepared within #ESfondi, #LZP #PostDoc #Pecdoktorantura #PostdocLatvia #PostdocLatvija. Nr.1.1.1.9/LZP/1/24/010 "Jauni TPP riboslēdža ligandi kā potenciālas antibiotikas"

[CASL_lab @LabCasl]

Ending the year on a high note with a joint paper with @chinsoonphan group: P450 Cyptide Synthase KwwB Catalyzes Trp-C5–Trp-N1 Cross-Linking and Accepts Diverse Precursor Peptides | Organic Letters https://t.co/KQh7TFyk4B

[CASL_lab @LabCasl]

Congratulations to Viktors on successfully defending his PhD thesis! Great job, and thanks @KrJaudzems for inviting us on this incredible journey! 🚀

[CASL_lab @LabCasl]

Excited to be a part of Highlighting Organic Chemistry in Latvia https://t.co/RE8THQSzrJ via @YouTube

[CASL_lab @LabCasl]

Exciting news — Niklāvs’ total synthesis of an indole alkaloid just got featured on the Organic Chemistry Portal!💪 https://t.co/loXTQOgqAO

[CASL_lab @LabCasl]

Niklāvs and Rebeka are presenting our latest results at #ACSFall2025. An amazing meeting and lots of inspiring discussions🧑‍🔬#FLPP

[CASL_lab @LabCasl]

Group Outing '25🤠 Just for clarification - it is Airsoft 😆

[CASL_lab @LabCasl]

Acetals from Esters in just one step: check out our latest paper in @JOC_OL #FLPP💪
https://t.co/I4Q6lJqfCW

[CASL_lab @LabCasl]

Check out our latest paper on selective ester reduction @JOC_OL conducted within our #FLPP project! 😎
https://t.co/O24iL3wdcV

[CASL_lab @LabCasl]

Happy to host a highly motivated pupil, Irina, within our #FLPP project on spider silk! 💪

[Chin-Soon Phan @chinsoonphan]

Happy to share our second independent work. We studied P450 biarylitide synthase, ShyB catalyze His-to-Tyr crosslink | Org Lett @JOC_OL
https://t.co/3hfhExVQbn

[CASL_lab @LabCasl]

Rebeka explains the principles of chromatography -one of the main workhorses in synthetic chemistry - to young chemists😎 #FLPP

[CASL_lab @LabCasl]

Niklāvs paper is online, good job! 🥂 https://t.co/YdYGUH7And

[CASL_lab @LabCasl]

Fruitful collaboration between our lab and @chinsoonphan group at @osi_lv . Hope it is just the beginning! 😉

[Chin-Soon Phan @chinsoonphan]

Happy to share our first independent work. We studied radical SAM enzyme, WprB catalyze Trp-to-Arg crosslink | ACS Chem Biol
https://t.co/EX7ccHcLfX

[National Research and Innovation Institute (NIRI) @niri_lv]

The Latvian Institute of Organic Synthesis invites applications for a Postdoctoral Researcher position in medicinal chemistry. Application Deadline: 13 February. Find out more: https://t.co/GOaHrZoae9

[CASL_lab @LabCasl]

Nice memories from our Christmas party 2023 🎅