Laith Alexander 🏳️‍🌈

Academic Clinical Fellow @KingsIoPPN | Resident Doctor @MaudsleyNHS | Brain, emotion, mood disorders | Views my own

[Suhana Ahmed @SuhanaAh]

'Academic Psychiatry meets Clinical Psychiatry'
31/10/25 @rcpsych
✅Juggling clinical work&&research @lynne_drummond
✅Short&longterm directions in psych&neuro research
✅Clinical work&Academia: What is left to do to bridge the gap?@Derektracy1
Book now
https://t.co/bx6mOuODFt

[Laith Alexander 🏳️‍🌈 @Laithalexander]

Amazing work and goes a long way in understanding lateral/medial prefrontal interactions underlying symptoms of depression + anxiety

[Neuroscience News @NeuroscienceNew]

“Dysfunction in primate dorsolateral prefrontal area 46 affects motivation and anxiety” by Christian M. Wood et al. Science

https://t.co/snLRhy2XwJ

[Luke Jelen @LukeJelen]

1/ Just out in @NatureMedicine : we show the opioid system modulates ketamine’s effects in major depressive disorder, with naltrexone pre‑treatment reducing acute glutamatergic activity and acute antidepressant effects. https://t.co/DErg4rqYz3

[Tony Cleare @TCleare]

Most studies on esketamine (and the UK licence) have been as add-on to antidepressants. This study suggests monotherapy may also be effective - although only short term data. As ever the challenge with (es)ketamine comes in the longer term.

[Laith Alexander 🏳️‍🌈 @Laithalexander]

Hot off the press!!! Prof Michael Browning from @UniofOxford presenting data from the PAX-D trial, looking a dopaminergic medication to augment the treatment of depression. #BAP2025

[Laith Alexander 🏳️‍🌈 @Laithalexander]

Prof Robinson describing the affective bias test, a translationally relevant assay to explore the effects of affective state on memory bias #BAP2025

[Laith Alexander 🏳️‍🌈 @Laithalexander]

Next up - Prof Emma Robinson, speaking about her exciting research developing preclinical models of psychiatric symptoms #BAP2025

[Laith Alexander 🏳️‍🌈 @Laithalexander]

The Head Twitch Response is not the perfect model of psychedelic experiences in mice #BAP2025

[Laith Alexander 🏳️‍🌈 @Laithalexander]

It is #BAP2025 and we are at the first symposium of the day! Starting with Dr Thomas Blackmore and preclinical models of psychedelic efficacy. Exciting.

[Christoph Mueller @DrChrisMueller]

Our new @NIHRMaudsleyBRC CRIS study shows that bipolar disorder is associated with a lower risk of dementia than depression | The British Journal of Psychiatry | Cambridge Core - https://t.co/kMJjTmaCHG

[Laith Alexander 🏳️‍🌈 @Laithalexander]

Exploring the pyramids

[Laith Alexander 🏳️‍🌈 @Laithalexander]

@HattyFeldman @TheBJPsych Bipolar cohort was also younger, but we adjusted for age + age^2 in cox proportional hazard model

[Laith Alexander 🏳️‍🌈 @Laithalexander]

Paper out in @TheBJPsych exploring link between late-life depression vs. anxiety vs. bipolar disorder and dementia.

Compared to depression, anx had same risk but bipolar was lower. We found several demographic & clinical factors influencing risk too.

https://t.co/8XIpqH03w0

[Laith Alexander 🏳️‍🌈 @Laithalexander]

@HattyFeldman @TheBJPsych Definitely one possibility! Other things could be (2) survivor effect; (3) BPAD more 'distinguishable' than depression therefore less diagnostic overlap.

[Laith Alexander 🏳️‍🌈 @Laithalexander]

@wendyburn Thank you 🤩 hopefully last exam of my life

[Laith Alexander 🏳️‍🌈 @Laithalexander]

Absolutely delighted that I’ve finally passed CASC. So happy that ordeal is over, particularly after the run in with Guillain Barre.

[Laith Alexander 🏳️‍🌈 @Laithalexander]

@Repealist_ I’m sure you will ace it

[Laith Alexander 🏳️‍🌈 @Laithalexander]

@NikkiLCochrane Thanks so much Nikki :D

[Laith Alexander 🏳️‍🌈 @Laithalexander]

@Lau_Cob_ @KingsIoPPN @Euro_Psychiatry @MaudsleyNHS That is important research! But wasn’t the focus of the paper

[Laith Alexander 🏳️‍🌈 @Laithalexander]

Exploring Alhambra