CAR-T in RMDs brings promise, but many questions remain.
Prof Russka Shumnalieva highlights key challenges: cost and accessibility, long-term safety, patient selection and the need for randomised evidence.
#EULAR2026
Prof Russka Shumnalieva sets the scene: autoimmune rheumatic diseases remain highly heterogeneous, with diagnostic delays, chronic inflammation and progressive organ damage still driving major unmet needs.
This is why innovation must respond to real patient complexity.
#EULAR2026
According to George Bertsias, biological therapies in SLE may be considered when disease control remains incomplete despite standard care, particularly in patients with high clinical burden, ongoing activity or flares.
#EULAR2026
🌍 Sepsis Kills 1 in 5 People Who Die Worldwide. Most of those deaths occur where resources are limited.
What if improving sepsis outcomes did not begin with the latest biomarker, AI algorithm, or advanced monitoring device?
What if it began with ten practical steps that every health system could implement?
A new international SCCM-led consensus review provides a roadmap for improving sepsis care across low-resource settings, where approximately 85% of global sepsis cases and deaths occur.
The framework is built around the Sepsis Chain of Survival and proposes ten interconnected actions spanning the entire patient journey, from prevention to long-term recovery.
Key messages include:
🔹 Ensure reliable access to essential sepsis commodities, infrastructure, and equipment.
🔹 Train healthcare workers, caregivers, and communities to recognize sepsis "danger signs."
🔹 Strengthen infection prevention, vaccination programs, sanitation, and public awareness.
🔹 Implement systems for rapid recognition, triage, referral, and escalation.
🔹 Deliver guideline-based, time-critical interventions including antibiotics, oxygen, source control, and organ support.
🔹 Develop structured post-sepsis follow-up pathways.
🔹 Build sepsis registries and meaningful data systems.
🔹 Use continuous quality improvement programs and performance feedback.
🔹 Foster a culture of excellence, respect, teamwork, and patient-centered care.
🔹 Protect the well-being of patients, families, and healthcare professionals.
One aspect I particularly appreciate is that the authors emphasize that these steps are not sequential and not prescriptive. Instead, they are adaptable to local realities and resources, allowing health systems to prioritize interventions according to their specific needs.
For clinicians working in resource-limited environments, this paper is a reminder that improving sepsis outcomes is not solely about individual bedside decisions.
It is about building systems that consistently enable early recognition, timely treatment, continuous improvement, and long-term recovery.
The future of sepsis care may depend less on discovering new interventions and more on ensuring that proven interventions reach every patient who needs them.
Reference
Kortz TB, Hidalgo JL, Akech SO, Myatra SN, Maves RC, Perez-Fernandez J, et al. Ten Steps to Improve Sepsis Care in Low-Resource Settings. Critical Care Medicine. 2026. doi:10.1097/CCM.0000000000007090.
#Sepsis #CriticalCare #IntensiveCare #GlobalHealth #SurvivingSepsis #QualityImprovement #EmergencyMedicine #CriticalCareMedicine #PublicHealth #ICU #HealthcareLeadership #LowResourceSettings #MedicalEducation #PatientSafety #SCCM
【EULAR2026報告】
EULAR recommendations for the management of Polymyalgia Rheumatica and Large Vessel Vasculitis
👉新規発症PMRのadjunctive治療として、tocilizumabがmay be consider
👉再発/難治GCAのadjunctive治療としてTCZ、UPAがshould be consider
#EULAR2026