leo schärfen

assistant professor, maraganore fellow at RNA therapeutics institute, umass chan

[leo schärfen @LeoSchaerf]

Check out our work on RNA structure in introns! Testing >100k base pairing variants, we found that RNA structure can predictably tune gene expression. Just by changing intron sequence, we see a dynamic range of regulation comparable to messing e.g. with promoters.

[biorxiv_biochem @biorxiv_biochem]

Control of gene output by intron RNA structure https://t.co/AmMwg4QBEN #biorxiv_biochem

[Molecular Cell @MolecularCell]

Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis https://t.co/XvlKNlvI1e

[Molecular Cell @MolecularCell]

Tracking the folding of RNA at its birth https://t.co/4yIAqrmL98

[Molecular Cell @MolecularCell]

Online Now: Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis https://t.co/CjLYYvEiPs