Penis size is set before birth by maternal health, metabolism, and hormone exposure (including birth control)
Penis size is largely determined during fetal development through the maternal–placental endocrine system.
Masculinization depends on DHT acting locally in genital tissue. Fetal circulating DHT is often very low, which shows that the androgenic signal is generated inside tissues from precursors rather than delivered directly through blood.
A major part of this signal comes from the backdoor pathway. Placental progesterone is converted across fetal tissues into intermediates such as androsterone, which are then converted locally into DHT in target organs. This pathway bypasses testosterone as an obligatory step.
The placenta provides a continuous supply of progesterone derived from maternal cholesterol, so androgen production depends on maternal substrate availability and its processing across fetal liver, adrenal glands, and peripheral tissues.
The system is distributed and depends on coordinated enzymatic activity rather than a single endocrine source.
Conversion efficiency depends on metabolic conditions. Thyroid function, mitochondrial activity, oxygen availability, and stress signaling determine whether progesterone is efficiently converted into androgenic intermediates or diverted toward other pathways.
Maternal endocrine state directly modifies these conditions. Hormonal contraceptives suppress endogenous progesterone production, alter estrogen signaling, and modify stress-axis regulation, replacing a cyclical endocrine pattern with a static pharmacological one.
This changes substrate dynamics, timing, and pathway organization during fetal development.
Synthetic progestins are not equivalent to physiological progesterone. They activate receptors but do not function as interchangeable substrates within steroidogenesis, so downstream androgen and neurosteroid pathways are altered.
Puberty mainly amplifies androgen exposure and completes growth. The structural baseline is established earlier through progesterone availability, metabolic capacity, enzyme expression, and local DHT production shaped by the maternal environment.
@utfess Punyaku score drilbit udah bagus, cuman belum dinilai sama dosennya sampe sekarang. Tugas 3 aja baru dinilai tadi banget, terus nilai nya 70, direvisi aja udah gak bisa. Tenggant waktu nya udah habis. Kesel banget
@worksfess Aku pertama kali kerja pun di pabrik nder, hari kedua masuk kerja udah lembur, kerja 13 jam full berdiri, dan itu full 1 bukan kerja. Mau nangis rasanya, tapi sepadan sih sama uang lemburannya.
@txtdrimedia Sumpah RSUD tuh kenapa sih, padahal RSUD nih punya pemerintah, taoi pelayanan untuk masyarakat ke bawah bener2 buruk. Bapak ku juga pernah dibawa ke igd RSUD cuman didiemin doang di sofa "DI SOFA" gak ditangani sama sekali, mentang2 pake BPJS. Dan yak ngeliat bapak didiemin gitu-
@txtdrimedia Liat bapak didiemin gitu gak tega lah. Kubawa cabut dari RSUD tuh ku bawa ke rumah sakit swasta, dan yak langsung ditangani, yang bikin geram nya tuh, waktu itu bapak divonis serangan jantung. Kalau aku nunggu terus di RSUD itu mau gimana bapaku nanti, untngnya aku bw ke rs lain
@widiww61@tanyakanrl https://t.co/xG1n8ncmrS
Disini kak, tapi kalau mau kek punyaku yang ada warna silvernya, itu harus dikasih note dipesanannya, biar gak dikirim full motif