Martinez Laurent

Research Director @I2mcT Head @LiMitAging Team "There is a crack in everything, that's how the light gets in"

[Martinez Laurent @LiMitAging]

Thanks @josepjulve for associating us with this review revisiting #atherosclerosis through an immunometabolic lens, highlighting how cholesterol-lowering therapies modulate immune metabolism and inflammation @I2mcT @INSPIREPlatfor1 https://t.co/1hzDxrY8fa #mdpijcm via @JCM_MDPI

[Eric Topol @EricTopol]

Boosting mitochondria number and function to slow cellular aging
https://t.co/h9CqQ9f263
https://t.co/ZnbqwAwdQG

[Martinez Laurent @LiMitAging]

Our last paper Is out! We identify plasma apolipoproteins J and L1 as novel determinants of steatohepatitis (MASH) in individuals with obesity — both improving diagnostic accuracy beyond traditional risk factors. #MASH @INSPIREPlatfor1 @I2mcT https://t.co/xTman3gDqs

[INSPIRE Platform - IHU HealthAge @INSPIREPlatfor1]

Organ age and mortality in "Plasma proteomics links brain and immune system aging with healthspan and longevity." https://t.co/Czy9zpbsv7 @brunovellas @I2mcT @LiMitAging

[Martinez Laurent @LiMitAging]

A step forward in aging biomarker research from @INSPIREPlatfor1 @I2mcT & @InfinityTLS! For the first time, single-cell measurement of energy metabolism in T cells from a simple blood test can detect risk of functional decline. #IHU_HealthAge @Madam_Mito
https://t.co/vyXK6mJqsE

[Bruno Vellas @brunovellas]

Glad to see that paper from our team on Intrinsic capacity Icope step 1 in Nature Aging today https://t.co/hjkZxmFszb

[Martinez Laurent @LiMitAging]

Excited to share our new study conducted within the @INSPIREPlatfor1 IHU HealthAge: apolipoprotein profiling helps improve prediction of cardiovascular events in the general population @I2mcT @ATH_Plus
https://t.co/fLmG0tYdtG

[Bruno Vellas @brunovellas]

L’équipe de l’IHU HealthAge en collaboration avec le @BuckInstitute fait partie des 40 équipes semi finalistes du @xprize healthspan pour le projet ICOPE INTENSE https://t.co/jLzYTYSgv2

[INSPIRE Platform - IHU HealthAge @INSPIREPlatfor1]

The impact on research ? : "Mitochondrial segmentation and function prediction in live-cell images with deep learning" https://t.co/5rdz0jqw2c @brunovellas @isaperarnau @RestoreInstitut @InfinityTLS @I2mcT @LiMitAging

[Bruno Vellas @brunovellas]

Implementing the WHO ICOPE program in clinical practice: three years of lessons from monitoring 27,082 participants… https://t.co/nm7vu42enH

[Martinez Laurent @LiMitAging]

@INSPIREPlatfor1

[Madam Mitochondria @Madam_Mito]

A panoramic view of cell population dynamics in mammalian aging;

https://t.co/IUsI0i43Wi

[Martin Picard @MitoPsychoBio]

If we look at thousands of proteins (i.e., signals) in the human blood, the protein most associated with chronic physical and mental illnesses is the **same protein** as the top marker for mitochondrial diseases: GDF15

When mitochondria cannot flux energy properly, the cell makes and secretes GDF15 in the blood to alert other cells

Some highlight by Cynthia Liu in our group:
- GDF15 is the top predictor for most diseases

- GDF15 associated with diabetes is among the most significant protein-prevalent disease associations
Based on p-value, GDF15 was most significantly associated with disease.

- “GDF15 was associated with the most diseases, containing 205 prevalent and 397 incident diseases, generally acting as a risk factor except for three incident diseases (respiratory diseases affecting the interstitium, disorders of magnesium metabolism, and peripheral artery disease).”

- “GDF15, similar to its high ranking with protein-disease pleiotropy, ranked second for protein-trait associations, boasting a substantial 428 associations.”Significant associations with many lipid metabolite markers.

- Mental disorders like anxiety disorders, depression, and mood disorders, along with mental health-related traits, also exhibited substantial proteomic signatures including elevated GDF15

- “The fluid intelligence score and various types of dementia shared significant proteins such as NEFL and GDF15 (Figure 2G)”

- “GDF15, the protein with pleiotropic effects, was causally associated with several autoimmune diseases, including ulcerative colitis and rheumatoid arthritis (Figure 6B).”

Data from >53,000 people in the UK Biobank

Full paper here:
https://t.co/F3dn16E0t2

Resource to explore your favorite protein or disease/trait of interest: https://t.co/BjpilkdtHW

[Martinez Laurent @LiMitAging]

Exited to share our latest review with @SoutoPhilipe
on #Sarcopenia & the biological determinants of aging; Winner is Mitochondrial dysfunction! 🧬 We dive into the role of geroscience in age-related muscle decline.@brunovellas @INSPIREPlatfor1 @I2mcT

https://t.co/CdEgU0ItX8

[Martin Picard @MitoPsychoBio]

The powerhouse analogy has expired

Like social organisms mitochondria differentiate and specialize to accomplish complex functions

🧵

[Bruno Vellas @brunovellas]

IHU Health Age Scientific Advisory Board

[Martinez Laurent @LiMitAging]

Excited to share our collaborative study with @BarteltLab @MoriLabe @HenverBrunetta, now online @embojournal on a novel function of mitochondrial IF1 in thermogenesis. Grateful for the support from IHU HealthAge @INSPIREPlatfor1 @I2mcT @MitoAging
https://t.co/BhgPbcjOrP

[Martin Picard @MitoPsychoBio]

The time to think and inquire are precious.

Inquiring means to contemplate a problem without needing an immediate answer, to sit in the unknown long enough that different kinds of answers emerge. Important part of the process of discovery.

https://t.co/vWgTsld4uJ

[INSPIRE Platform - IHU HealthAge @INSPIREPlatfor1]

Congratulations to Y ROLLAND from Toulouse for his last publication about #ICOPE : "Implementing clinical operationalization of sarcopenia: the contribution of WHO ICOPE program." https://t.co/8oOh99CwXs @brunovellas
@isaperarnau @RestoreInstitut @InfinityTLS @I2mcT

[Martinez Laurent @LiMitAging]

Thrilled to be associated with this study from @BarteltLab, @MoriLab, and the brilliant @HenverBrunetta, uncovering a novel role of mitochondrial IF1 in the reverse mode of ATP synthase, enhancing bioenergetics in brown adipocytes @I2mcT @INSPIREPlatfor1 https://t.co/YziOYg5vWY

[Martinez Laurent @LiMitAging]

Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age https://t.co/Dc4yW5KDRF