Lucca Derks

instead of here! | PhD Candidate | Van Boxtel Group | Utrecht, NL | single-cell WGS of & CRISPRing in blood cells

[Lucca Derks @luccaderks]

@MatusMedo @NatureComms Fair question! We add a reference mutation matrix of historic samples, containing SBS1, SBS5, SBS18 and SBSblood/HSPC to the sig extraction step. We use a cutoff for the cosine similarity of 0.9. Unknown sigs we investigate manually like SBSD in https://t.co/42TjqApCl5

[Lucca Derks @luccaderks]

@MatusMedo @NatureComms MutationalPatterns contains an option for this based on the cosine similarity: https://t.co/okfIiLNZBc

[Lucca Derks @luccaderks]

@MatusMedo @NatureComms Thank you for the detailed reply! We are aware of residual fitting issues but seeing the comparison is very clarifying. In general, we identify the signatures in our samples by de novo extraction+comparison to COSMIC, and refit using only those. This is a good example of why :)

[Lucca Derks @luccaderks]

Now out in @CellStemCell! https://t.co/rAoWzX6G3B

[Lucca Derks @luccaderks]

Mutations accumulate in all of our stem cells, so what? Ruben and I review this topic; from detection methods to how selection dynamics in stem cell pools are affected by their mutation load, check it out!

[Cell Stem Cell @CellStemCell]

Online Now! Stem cell mutations, associated cancer risk, and consequences for regenerative medicine https://t.co/S0BX5mGbOG #stemcells

[Barbara Braams @Barbara_Braams]

🚀 Vote the big Hoe?Zo! Show questions book to the finals of the #AmSIA Awards! 🚀

🗳️Finalists are selected based on public voting🗳️ Please help us and cast your vote here 👉 https://t.co/pUWmMFsMmI

RT = 🙏🙏🙏

https://t.co/R6e5Lwego3

[PrinsesMáximaCentrum @prinsesmaximac]

New software, developed by the Máxima Center's @BoxtelLab, allows scientists to more accurately see what changes are present in the DNA of a single cell. This makes it easier to compare the DNA of different cells. Read: https://t.co/x0gZeGj7zo @oncodeinstitute

[PrinsesMáximaCentrum @prinsesmaximac]

Two researchers who recently obtained their PhD in the Máxima have been awarded a Veni grant 👏 Both scientists will add to a better understanding of how leukemia can develop, working with @BoxtelLab. Congratulations, @ingevdwerf and Sjors Middelkamp! Read https://t.co/LBoAOcEP44

[Lucca Derks @luccaderks]

And very happy for this opportunity to catch up with the @KorbelGroup and hear about the great progress in their research! (The traditional pizza and radler in Neckarwiese was also welcome...)

[Lucca Derks @luccaderks]

Excited (I promise) to present our (@BoxtelLab) ongoing research on chemotherapy-induced mutational ageing of the genome in hematopoietic (single) cells at #EESAgeing!

[Lucca Derks @luccaderks]

Very happy to be part of this year's Hoe?Zo! Show team of PhD candidates! Answering questions is a lot more fun with props...

[Barbara Braams @Barbara_Braams]

Volle zaal voor de start van de eerste Hoe?Zo! Show van dit seizoen in Theater Castellum in Alpen a/d Rijn!

[Flavia Peci, PhD @peciflavia]

“It takes a village to raise a child” and it takes an amazing group to raise great scientists!
Merry Christmas and Happy New Year from our lab to yours 🎄🎅🏼🧬
@BoxtelLab @prinsesmaximac

[PrinsesMáximaCentrum @prinsesmaximac]

Onderzoekgroepsleider Ruben van Boxtel vertelde vandaag bij @HumbertoTan over zijn onderzoek naar mogelijke 'superstamcellen'. Nieuwsgierig? Luister het fragment (start 1.21.30) via de link terug.
https://t.co/en2YSMns5v @BoxtelLab #stamcellen #kinderkanker #onderzoek

[New York Stem Cell Foundation Research Institute @nyscf]

We are delighted to announce the 2022 class of NYSCF - Robertson Investigators: @lydfinley (@MSKCancerCenter), @karalmckinley (@HSCRB), Ruben van Boxtel (@prinsesmaximac), Cate Jensen Peña (@Princeton), @AmberAlhadeff (@Penn), & Tomasz Nowakowski (@ucsf): https://t.co/yLIrziYUO0

[Maik Derks @DerksMaik]

Got the super cool opportunity to talk in the dutch radio about our group's recent paper on the mode of action of #teixobactin!!
Huge thanks & congratz to @shukla_rhythm @MarkusWeingarth for the great work!

[Lucca Derks @luccaderks]

@HopsWolfram Congrats Wolfy!! Hope you still introduce the concept using Bach :)

[Hugo Snippert @Snippertlab]

Concerned about undesired #CRISPR off-targets? Our latest work on error-free #GenomeEditing in #organoids without DSB cleavage. Major advantage: generate knock-in lines in 2wks incl. cloning! Efficiency: triple ki's in 1 go. Plasmids @addgene A thread 1/5 https://t.co/dGClUc6yvN