The Manetsch Lab - Northeastern University

we look to answer fundamental questions rooted in medicinal chemistry and chemical biology using organic synthesis | student run

[The Manetsch Lab - Northeastern University @Manetsch_Lab]

Celebrating Women’s Careers in Chemistry symposium was an exceptional evening! The streptothricin F team was well represented with posters by Yuliya (5th year) and Macy (2nd year)👩‍🔬

Thank you @AcsWcc!

[The Manetsch Lab - Northeastern University @Manetsch_Lab]

We are exceptionally proud of our very own Dr. Alicia Wagner @medicinAlicia who has accepted a position at Arrowhead Pharmaceuticals!!

Although we're sad to see her go, we can't wait to see the incredible things she'll achieve in her next chapter! 🥳🌟

[The Manetsch Lab - Northeastern University @Manetsch_Lab]

Roger (5th yr PhD candidate) did an incredible job at the 2025 Pharm Sci Research Showcase with a flash talk and poster highlighting his latest optimizations of carboxamide antimalarials!

Thanks to the organizers @NortheasternSOP for a wonderful day!!🧪✨

[The Manetsch Lab - Northeastern University @Manetsch_Lab]

And we'd like to especially recognize one of our incredible undergrads Ally Kleinmann ('26) for presenting her work on the synthesis of Streptothricin sugar cores. Go team SF!🦠🧪

[The Manetsch Lab - Northeastern University @Manetsch_Lab]

3rd yr PhD Candidates Ben and Arif presented their work on irresistible antimalarials and xanthommatin driven photocatalysis, respectively.
Special congrats to Khaly (5th yr PhD Candidate) for receiving an Outstanding Poster Presentation Award!
We are so proud!!🥳🥳
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[The Manetsch Lab - Northeastern University @Manetsch_Lab]

We are thrilled to share about our wonderful lab representation at the ACS Northeast Regional Discussion 2025, highlighting two oral presentations - Yuliya Marusyk in Organic Synthesis and Roger Trombley in Medicinal Chemistry
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[Alicia Wagner @medicinAlicia]

belated, but I did it!! I defended!!!

I'm the luckiest gal in the world to have all the love and support that I do in the @Manetsch_Lab and @NU_Chemistry ♥️🖤

excited to do some cool science before jetting off to my super secret next step, coming to a tweet near you eventually

[The Manetsch Lab - Northeastern University @Manetsch_Lab]

Earlier this month, a new PhD was added to the roster: Dr. Alicia Wagner, whose work focused on the discovery and optimization of several antimalarial chemotypes!

We're all proud of the work she's accomplished here, and will be cheering her on in the next step in her career!🍾🎉

[The Manetsch Lab - Northeastern University @Manetsch_Lab]

The Manetsch Lab twitter has been relatively silent over the past few months as our "social media manager" (@medicinAlicia, the secret is out) has been occupied with a few other things. A few exciting tweets coming to you soon!

[UGA CTEGD @CTEGD]

Research news, trainee spotlights, and more in the latest CTEGD newsletter. Read all about it!
https://t.co/zVxJzjqTU1

[The Manetsch Lab - Northeastern University @Manetsch_Lab]

Congrats to Lili and team for the publication of the first total synthesis of xanthommatin!🦑

This naturally occuring pigment (isolated from cephalopods) has many applications, one being novel sunscreens (@leiladeravi, @SeaspireSkin).

Read more below: https://t.co/GePdJmb98A

[The Manetsch Lab - Northeastern University @Manetsch_Lab]

If you want to read about some of Lili's chalcogen-centered click chemistry work, check out our recent publication in @ChemCommun below:

https://t.co/cq9tnDAUuP

[The Manetsch Lab - Northeastern University @Manetsch_Lab]

Another month, another PhD graduate in the house (lab)!!!! 🎉

Many congrats to Dr. Lili Huang, master of med chem, click chemistry, and synthesis of xanthommatin (coming to a tweet near you soon)!

We are so proud of Lili and excited to see what is next for her!

[Chemical Communications @ChemCommun]

We are excited to share our ChemComm 60th Anniversary Collection with you.

Take a look at the new Communication article from Roman Manetsch and first authors Lili Huang, Prakash T. Parvatkar

@Manetsch_Lab @PrakashParvatk1

https://t.co/irWH54aRL5

[Alicia Wagner @medicinAlicia]

So happy to see this work out in @ChemCommun!

Increased reactivity of selenium + electron deficient azide + Mcl-1 = the templated formation of an amide-linked Mcl-1 inhibitor in situ (via KTGS). And at 4 C to boot!

Check it out to learn more about this new click reaction! 🧪

[Prakash Parvatkar @PrakashParvatk1]

Check out our recently published article in chemical communication on seleno-click amidation in KTGS -
https://t.co/f5VWwjLecF
DOI: https://t.co/f5CfzUoWfJ

[Leticia Gomes @leticia_a_gomes]

🚀 Community college students, mark your calendars for Sept 28! Join us at Northeastern for a free event hosted by ADSE to explore 4-year college opportunities. Learn about applications, and student experiences, and take a campus tour. Lunch included! 🍽️ Details below. #ADSE

[Alicia Wagner @medicinAlicia]

Today's the day!!!

If you are interested to hear an antimalarial drug discovery talk (from screen to in vivo candidate) please join me in the @AcsMedi award session in Mile High Ballroom 3A 2:10 - 2:45 pm. Lots of excellent talks after, too!