Manojit Swamynathan

postdoctoral researcher in @SJMorrison_ lab @CRI_UTSW | previously @CSHL @stonybrooku

[Manojit Swamynathan @manojit_ms]

Super thrilled to share my PhD thesis work, now out in @ScienceMagazine, revealing an unexpected redox checkpoint during endosomal progression via oxidative control of the ancestral PI 3-Kinase VPS34
https://t.co/y6Rhjw89M6

[Nature Biotechnology @NatureBiotech]

A prime editor screen systematically identifies deleterious synonymous variants in human cells https://t.co/wwmvw2Uk0z
https://t.co/N29xsisgMf

[eLife - the journal @eLife]

Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation
https://t.co/wfPmwrWa9b

[Rushika M. Perera @rushika_perera]

Our latest study out in @MolecularCell explores how and why MHC class I is aberrantly targeted for degradation via the autophagy-lysosome pathway in pancreatic cancer. Congrats to postdoc extraordinaire @marineberquez for leading this study! @UCSFAnatomy @UCSFCancer

[Cell Stem Cell @CellStemCell]

Ferroptosis susceptibility in hippocampal neural precursor cells influences neurogenesis and memory across aging https://t.co/BYkltPxP0I

[Nature Metabolism @NatMetabolism]

COMMENT | JO Lundberg & MO Bergo (Karolinska Institute, SE)

This Comment explores how early mechanistic hypotheses can become entrenched #dietary #dogmas, affecting #research, policy, and public understanding

https://t.co/JEQps3XNgn

[Will Hill @DrWilliamHill]

Incredible to see our work out today in Cell: "Plasma signals of lung tumor promotion for molecular cancer prevention."
https://t.co/ISi2UZI03Z

[Cell Metabolism @Cell_Metabolism]

DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function https://t.co/xSKC439wGZ

[Ｊｕｎ Ｙａｓｕｄａ @jyasuda1]

CRISPR-CAS9によるゲノム編集でのスクリーニングの結果とその前段階を同じ細胞で分別できる系であるPerturbFateという技術を開発、BRAFが活性化する悪性黒色腫に対するヴェムラフェニブ治療への抵抗性を担う分子機構を網羅的に明らかにした論文。Nature。
https://t.co/fCIvdHReQX

[Marcus Goncalves @MarcusDGon]

Ultraprocessed foods and obesity: Interpreting the evidence | Science https://t.co/YVtGxLOv54

[Nature Metabolism @NatMetabolism]

#Throwback

METABOLIC MESSENGERS | L. A. J. O’Neill et al

Itaconate

https://t.co/NnV58vKXdl

[Toni Choueiri, MD @DrChoueiri]

Detecting lung cancer 5 years before it happens, in @CellCellPress courtesy of the @CharlesSwanton group.

Astonishing translational work !

https://t.co/EvUmIGVLgs

[Cell Reports @CellReports]

Targeting EP2/EP4-driven expansion of suppressive VSIG4high macrophages overcomes immunotherapy resistance in colorectal cancer https://t.co/ck15pRBkSc

[Molecular Cell @MolecularCell]

Online Now: Reductive death is averted by a conserved de novo lipogenic switch https://t.co/53oRSo70qf

[Nature Metabolism @NatMetabolism]

#Throwback

REVIEW | C Cuparencu et al

Towards nutrition with precision: unlocking biomarkers as dietary assessment tools

https://t.co/NZFIPSyzRR

[Ethan J. Weiss @ethanjweiss]

As a non-oncologist, i feel quite comfortable jumping on the bandwagon here. I can count the number of times I've seen unsolvable problems in medicine get solved in my lifetime. No, this is not a cure, but there has been no greater challenge than pancreatic cancer. Nothing worked. Now this...

These results are simply spectacular

Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer | New England Journal of Medicine https://t.co/a52WwDQ2Ju

[Cell Biology J-Club @cell_club]

Spermine is an endogenous iron chelator that inhibits ferroptosis | Nature https://t.co/tpcnSZKUEZ

[James Olzmann @OlzmannLab]

Exciting new work from @RobertoZoncu, led by all star first authors @clairegoul and @aakritijain24 reveals the mechanism mediating the sensing of lysosomal damage and recruitment of ESCRT for membrane repair. Beautiful work!🤩
https://t.co/fpazvFMciI

[Waggoner Lab @LabWaggoner]

Regulatory factor X 7 limits Myc activity during B cell activation and suppresses Myc-dependent lymphomagenesis @NatImmunol
https://t.co/b4kCtCDltb

[nature @Nature]

Nature research paper: Mechanism of age-related accumulation of mtDNA mutations in human blood

https://t.co/0HUyghafuZ

[nature @Nature]

Nature research paper: Universal transcriptomic hallmarks of mammalian ageing and mortality

https://t.co/9IbuF2tK5H