Manthan

Curious Mind doing science to understand nature of the cell. NGS, Epigenomics, postdoc MadapuraLab Blizard Institute. QMUL

[Manthan @Manthan5277]

Delighted to share our work on #TE deregulation in #Preeclampsia.
We show upregulation of multiple TE-subfamilies in Preeclampsia (PE). Moreover, type-1 IFN responsive genes expression goes up in PE.

[Pradeepa Madapura @PradeepMadapura]

We are excited to share our latest work: Transposable elements are deregulated in #Preeclampsia, which correlates with type-I IFN levels. "TE signature in maternal cell-free RNA can predict preeclampsia before the appearance of symptoms" https://t.co/4aWHNlaoA4

[Molecular Cell @MolecularCell]

Online Now: Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes https://t.co/YHi8dr6Lmg

[Ming "Tommy" Tang @tangming2005]

Extensive enhancer crosstalk controls PPARG2 activation during adipogenesis https://t.co/QWg5mfHabX

[nature @Nature]

Nature research paper: Ageing promotes metastasis via activation of the integrated stress response

https://t.co/X6BlKnQaqJ

[Christoph Bock Lab @ CeMM & MedUni Vienna @BockLab]

CellWhisperer can now run on your laptop. Talk to your cells! And check out our paper: https://t.co/ZCzgsKWLCv

[bioRxiv Bioinfo @biorxiv_bioinfo]

TFBSpedia: a comprehensive human and mouse transcription factor binding sites database https://t.co/ggt8W5nyyk #biorxiv_bioinfo

[Ming "Tommy" Tang @tangming2005]

10 websites for drawing scientific figures 👇

[Ming "Tommy" Tang @tangming2005]

5 websites to analyze GEO RNAseq data without a single line of code 👇 AI tools as a bonus in the end!

[@qmulepigenetics @QMULepigenetics]

We're excited to announce that our 2nd Annual QMUL Centre for Epigenetics Conference is happening on June 18th, 2026 at Mile End campus.
To find out more and book your tickets, please follow this link: https://t.co/63lKAfVhbP

[Ryota IINO 飯野亮太 @ryotaiino]

Very fast CRISPR and its applications from Taekjip Ha lab.
Very fast CRISPR on demand
https://t.co/ddsAxcczIX
https://t.co/dxw3uekBjr
Cohesin drives chromatin scanning during the RAD51-mediated homology search
https://t.co/GyBihdRhAt
#bps2026

[Russell Ryan @RussellJHRyan]

New from us in @CellGenomics: Using FFPE-compatible Hi-C to detect oncogenic rearrangements genome-wide in routine lymphoid cancer biopsies. Congrats to first author pathologist-scientist Jamin Wu, co-senior author Matija Snuderl @NYUGSOM_Path, and @ArimaGenomics.

[Nilimesh Das @NilimeshDa6026]

RNA-binding protein MYC binds to nascent, intronic RNA.
It then forms multimers, and suppresses the accumulation of R-loop to prevent innate immune signalling.

https://t.co/xbvnKICHq2

[Molecular Cell @MolecularCell]

Online Now: BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes https://t.co/GYfLVMt3A8

[Molecular Cell @MolecularCell]

Online Now: The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2 https://t.co/6Wx6lSYWlz

[Ronan O'Malley @omalley_ronan]

New preprint! The same TFs can drive distinct regulatory programs depending on where they bind.
TSS → rapid stress responses
Intronic & upstream → cell-type programs
Enhancer-like CRMs → embryo/meristem programs
Coding-sequence binding → repression
https://t.co/KwDWtkxJKU

[Molecular Cell @MolecularCell]

Online Now: Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders https://t.co/BtJHxC7NU1

[Molecular Cell @MolecularCell]

Online Now: RBPscan: A quantitative in vivo tool for profiling RNA-binding protein interactions https://t.co/rwCXka8sMZ

[Ming "Tommy" Tang @tangming2005]

A human pan-disease blood atlas of the circulating proteome | Science https://t.co/5zqjIkiJKx

[bioRxiv Bioinfo @biorxiv_bioinfo]

PlotGDP: an AI Agent for Bioinformatics Plotting https://t.co/vjfELV03YL #biorxiv_bioinfo

[Pradeepa Madapura @PradeepMadapura]

Check this new work on BRD4's role in preventing the premature activation of developmental transcription factors via #Polycomb, providing new mechanistic insights into the pathogenesis of neurodevelopmental disorder #CdLS #NDDs, #chromatinopathies https://t.co/H3x3WJ9cUK

[Xuebing Wu @wu_xuebing]

Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element https://t.co/MynOLLNvXi