Incredibly excited that our paper linking single molecule states of TF binding to gene expression using quantitative thermodynamic models is out in Nature today. An amazing collaboration with the Bintu Lab. Congrats to Ben, Michaela, and Julia! https://t.co/4zjMOlOgVV
We are excited about future applications of RASAM to better define the regulatory logic that underlies chromatin maturation across different cellular contexts.
Beyond excited to share my main postdoctoral work. We developed a robust mouse cortical organoid system, which recapitulates in vivo tempos and cellular diversity, and applied it to identify gene expression changes across subspecies during development. https://t.co/XQLx6TF3T2
Excited to present my first large piece of work of my PhD: ATP-dependent remodeling of chromatin condensates uncovers distinct mesoscale effects of two remodelers. https://t.co/FWJsN9b5xg
Thank you to everyone in the Narlikar/Ramani labs who made it possible!
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Grateful for the chance to sit down with @sharilwiseman@NatureNeuro to discuss my lab’s work on glia and some of the challenges I’ve faced as a trans and indigenous person on the path to a career in academic science.
Excited to share our latest paper led by @rachelaglenn. We generated a genetically diverse mouse pluripotent stem cell panel from the Diversity Outbred stock and outline experimental approaches for "population-scale" in vitro directed differentiation.
https://t.co/hYkW2fJ1qo
Gladstone Investigator Vijay Ramani (@vram142) and collaborator Siva Kasinathan (@SivaKasinathan) led a study that demonstrates how two new tools can perform single-cell genetic sequencing using less DNA than required by today’s gold-standard methods.
https://t.co/UUNZmbNYkh
exciting new techniques from @vram142's lab! Adaptations of SMRT and SAMOSA with tagmentation for much lower input material for the former, and addition of chromatin accessibility for the latter. https://t.co/zxwTET3rOq
Neurons and astrocytes closely coordinate their gene expression, in a program we call “SNAP” – a collaboration that we find to be central in protection from schizophrenia and cognitive aging.
https://t.co/dj0jMklreP
Check out this video interview with postdoc Marty Yang. Yang shares what brought him to Gladstone, his future career goals, and his passion for mentoring.
https://t.co/tteCpZZJ7i