Takeya Masubuchi

Assistant Project Scientist @UCSanDiego; #Immunity #Cellbio #Biochemistry #Biophysics #Reconstitution #Microscopy; receptor dynamics and cell communication

[Takeya Masubuchi @MasubuchiTakeya]

@sciqst @hui_enfu @jackbuimdphd @ZhengtingZou @CWu2009 Great question! A fully humanized PD-1 mouse model or other animal models closer to humans might be the way forward. Still plenty of work ahead!

[Takeya Masubuchi @MasubuchiTakeya]

Excited to share our latest paper describing the functional divergence of PD-1 across species. Thank you for @hui_enfu for the invaluable guidance, and @jackbuimdphd @ZhengtingZou @CWu2009 et al. for wonderful collaboration!
https://t.co/sB6Y2F34LB
https://t.co/AwJf8Z5lCA.

[Enfu Hui @hui_enfu]

Thrilled to share our @SciImmunology paper! Rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. Kudos to @MasubuchiTakeya for leading this work, and @jackbuimdphd @ZhengtingZou @CWu2009 et al. for collaboration.https://t.co/N1NbfwibLA See also excellent media report by @mario_maguilera https://t.co/TiHuiMuesI

[Takeya Masubuchi @MasubuchiTakeya]

I'm deeply grateful for the support provided by the @HFSP long-term fellowship and the @JST_Kisokenkyu PRESTO (Sakigake) Grant for this work!

[Takeya Masubuchi @MasubuchiTakeya]

@YunlongZhao15 @hui_enfu @jackbuimdphd @ZhengtingZou @CWu2009 Thanks Yunlong! This is a great start of 2025. Wish you a wonderful year, too!

[Enfu Hui @hui_enfu]

Thrilled to share our @SciImmunology paper! Rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. Kudos to @MasubuchiTakeya for leading this work, and @jackbuimdphd @ZhengtingZou @CWu2009 et al. for collaboration.https://t.co/N1NbfwibLA See also excellent media report by @mario_maguilera https://t.co/TiHuiMuesI

[Enfu Hui @hui_enfu]

Today we report on @eLife mechanisms by which similar immune checkpoint receptors show different preferences on SHP1/2, and that PD1 has an atypical ITIM. Congrats to @XiaozhengX @MasubuchiTakeya Thanks @ReviewCommons for reviewing & referring our preprint https://t.co/EPodKnyWpW

[Xiaozheng Xu @XiaozhengX]

Great to see our eLife paper entitled "Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors" published online!!! https://t.co/uFJI0W5tKb @eLife @hui_enfu @YunlongZhao15 @MasubuchiTakeya @XiaozhengX

[Takeya Masubuchi @MasubuchiTakeya]

Excited to share our new paper @CellCellPress! Really happy to be co-author of this amazing work. Congratulations to all!

[Enfu Hui @hui_enfu]

CD3e improves CAR-T signaling and anti-tumor function @CellCellPress! Great to be part of this amazing collaboration with Chenqi Xu and Catherine Wu etc. Congrats to @MasubuchiTakeya fellow of @HFSP and the team! https://t.co/aSgEP9C7ua

[Takeya Masubuchi @MasubuchiTakeya]

Review article of Single molecule protein sequencing. Reminds me discussion with Dr. M.
https://t.co/HHljRMl8Q9