Our study to understand how kinesin-8 can have both motility and microtubule depolymerization activities came out!
7 #CryoEM structures @SosaLab4. Data collected @SEMC_NYSBC.
Collaboration with @AllinghamJohn lab, biochem & X-ray structure by Byron Hunter.
https://t.co/wKefPEusva
Our study to understand how kinesin-8 can have both motility and microtubule depolymerization activities
7 #CryoEM structures @SosaLab4
Data collected @SEMC_NYSBC
Collaboration with @AllinghamJohn lab, biochem & X-ray structure by Byron Hunter
#microtubule
https://t.co/XnHvNKwaqQ
1/ Excited to share our work on how kinesin binding protein (KIFBP) regulates kinesin! TL;DR: KIFBP remodels the kinesin motor to inhibit microtubule-binding
We are very excited to share our latest work, the high-resolution cryo-EM structure of the ex vivo cortical #microtubules from human parasite #Toxoplasma gondii. This work is in collaboration with David Sibley lab and @alanbrownhms lab.
https://t.co/lqnOvMT7Zv
Fascinating microtubule structures solved by sub-tomogram averaging using EMAN (@sludtke and Muyuan Chen), imaging in @chiulab, segmentation with Segger! Identified tubulin proteins in different arrangements along with other components https://t.co/QtJUG9xWgb
Another wonderful collaboration with @alanbrownhms and @DutcherLab. Here we put complementary data together to build the complete structure of two distinct radial spokes on doublet microtubule. It was also a great experience to coordinate with the Vale lab for paper submission.
First paper from my lab after entering a new field. Great collaboration with @alanbrownhms and @DutcherLab! In this paper we use high-resolution #cryoEM to identify 38 ciliary doublet associated proteins including 33 #microtubule inner proteins (#MIPs) 😎
https://t.co/EIT2PYXPwR
Here is what molecular motors, kinesins in this example, actually do to microtubules as they walk on them. 😵
Want to know how microtubules can survive in real life ? Have a look at our recent investigation:
https://t.co/nDRCU2U7ZG
@SamReckPeterson@christlet@Lblanchoin
Pre-print on our latest #PRC2 work, spearheaded by @vignesh_k757 and supported by many collaborators: Curtis Beck, @poepsel_lab, @malamenteau, Jennifer Kosmatka, Dan Toso at the #BACEM facility, and Marco Faini in the Aebersold Lab in Zurich. #cryoEM
https://t.co/Aumfmwqh10