The McDonnell Lab

Structural Biology Meets Autoimmunology!

[The McDonnell Lab @McDonnellLab]

Very happy to announce I have been awarded a Senior Fellowship from @VersusArthritis to work on diagnostics in Seronegative RA. Looking forward to the progress we will make together #RA #Seronegative #Diagnostic #NewChallenges

[The McDonnell Lab @McDonnellLab]

Another day at #SLEuro another day of McDonnell Lab research. Lucias late breaking poster is #28 and Junjie is talkingin the Comorbidities at lunch! Lots of SLE and APS/SLE to see!

[The McDonnell Lab @McDonnellLab]

So proud of Karen, Lucia and Christophe bringing APS research forward one step at a time #SLEuro2026

[The McDonnell Lab @McDonnellLab]

Thursday has lots of McDonnell Lab to see! Christophe speaks in the biomarker session in 1.06 and Thomas speaks in the APS session in Auditorum II, and Karens poster #7

[The McDonnell Lab @McDonnellLab]

McDonnell Lab on tour to Lisbon! We are at the SLEuro meeting, posters and talks across the full 4 days. Looking forward to catching up with collaborators and to making more!

[The McDonnell Lab @McDonnellLab]

@GNRailUK @MrChrisDPrice Its been a lot longer than 30 minutes. Been stuck between potters bar and hatfield for more than that.

[The McDonnell Lab @McDonnellLab]

Happy to share the latest paper from the McDonnell Lab

https://t.co/R1YjP7agtD

A full simulation of the C1q globular head, and its implication for CRP binding. Great work from Nicole and Christophe.

[Arthritis UK @arthritisukorg]

Researchers @KeeleUniversity have found that current care for musculoskeletal conditions like back pain and #osteoarthritis is failing to close an important ‘inequality gap’ in pain and disability. Read more: https://t.co/QvCqqCHeMs

[Alexander Heazell @MCR_SB_Research]

We're looking for volunteers who are UK-based midwives and obstetricians to participate in an online focus group on antenatal fetal monitoring. We would need no more than 90 minutes of your time. Please contact [email protected] if you're interested.

[The McDonnell Lab @McDonnellLab]

@GeorgeARobinson @iuis_online @britsocimm @uclmedsci @ucl Congrats George!!!

[George Robinson @GeorgeARobinson]

I’m humbled to be selected as an IUIS Rising Star and present at #IUIS2025 with 15 amazing early career investigators!
Huge thanks to @iuis_online for the recognition and @britsocimm for the nomination!
Excited to connect at the Congress!
https://t.co/gh6ZIMhX53
@uclmedsci
@ucl

[Mauri Lab UCL @Mauri_group]

Applications for our funded PhD position are now open!

https://t.co/ft8hTH7Pbz

[George Robinson @GeorgeARobinson]

Happy #2025DayOfImmunology!
I am hosting a unique (and free) in-person training opportunity for patients with #lupus to learn about the science of disease 🦠
Register here! ✍️
@VersusArthritis
@RoyalFreeChty
@LUPUSUK
@uclh
@uclmedsci
#WorldImmunologyDay

[APS Support UK @APSsupportUK]

A study led by Associate Professor Thomas McDonnell (@McDonnellLab) shows that plasmin cleavage of β2-glycoprotein I creates a novel S-shape with stronger pathogenic antibody binding. This may help explain autoantibody development in APS: https://t.co/VpoAW1GM78

[The McDonnell Lab @McDonnellLab]

This paper contains a plethora of different methods from different fields including ELISAs, mass spectrometry and SAXs to name a few! It was a real collaborative effort!

[The McDonnell Lab @McDonnellLab]

Happy to share our latest paper:

https://t.co/K6zgXYTXYJ

Showing a novel structure of B2GPI is formed after cleavage with plasmin, altering its ability to bind autoantibodies!

[Clinical and Experimental Rheumatology @clinexprheum]

The third 2025 issue is online https://t.co/ijT428tFLA with the One year in review on Systemic #Lupus Erythematosus https://t.co/ugJkwLtJHr

[George Robinson @GeorgeARobinson]

Today is #WORDDay2025! An incredibly important cause to raise awareness of young rheumatic diseases and improve research, care, and support for patients. Please spread the WORD and and follow @WORDDay_org to find out more 👇

[Arthritis UK @arthritisukorg]

It is estimated that 10,000 children under 16 years old have been diagnosed with #JIA. But it’s often overlooked and misunderstood. It's vital that we raise awareness and empower young people to thrive. We're here to support this #WORDDay2025: https://t.co/BkJV8H0yZG @WORDDay_org

[George Robinson @GeorgeARobinson]

@peijnuj Congratulations @peijnuj on the Best Oral PhD Presentation Award! Well deserved!