Esteban Finol, MD, DSc

Chercheur, passionné par le mot bien écrit et prononcé, par le contexte et le détail, par le rêve et l'effort, par l'Europe et sa culture. respect et diversité

[ShorterLab @ShorterLab]

Newton’s cradle-like allosteric mechanism explains regulatory RsmE RNA binding: https://t.co/7wbFCDLjZ3

[Giuditta De Lorenzo @serdelor]

Join our young, dynamic team in beautiful, windy Trieste!
We are looking for a motivated PhD student to work on neutralizing antibodies, vaccines, and antiviral peptides.
We aim to combine wet-lab expertise👨‍🔬with computational modeling👩‍💻to drive innovation in viral intervention

[Esteban Finol, MD, DSc @MiceDoctor]

@juannagel estos lea gusta bailar pegao con dios y el diablo

[Esteban Finol, MD, DSc @MiceDoctor]

@AdrianoAguzzi

[Esteban Finol, MD, DSc @MiceDoctor]

Roche being Roche. 👀

[Esteban Finol, MD, DSc @MiceDoctor]

@VirusesImmunity @bornali_27 @peowenlu @S_Tabachnikova @KerrieGreene_ @MitsuakiSawano @BrianneDressen @microbeminded2 @PutrinoLab @LeyingGuan very important work on these cases. I have a couple of comments. I’ll share them here.

[Esteban Finol, MD, DSc @MiceDoctor]

Great work on post-acute COVID-19 vaccination (PACV) syndrome, from @VirusesImmunity group.
However, I'm very disappointed by the extensive use of the term "post-vaccination syndrome" in the manuscript. it is too generic and it won't be handled properly by public opinion.

[Esteban Finol, MD, DSc @MiceDoctor]

These vague statements along with the "post-vaccination syndrome" term can backfire in the public opinion and public health badly.

[Esteban Finol, MD, DSc @MiceDoctor]

Great work on post-acute COVID-19 vaccination (PACV) syndrome, from @VirusesImmunity group.
However, I'm very disappointed by the extensive use of the term "post-vaccination syndrome" in the manuscript. it is too generic and it won't be handled properly by public opinion.

[Jon Douglas @atranscendedman]

Yale researchers studied 42 people with chronic illness after COVID-19 vaccination and found immune differences, including reduced CD4 T cells and increased TNFα+ CD8 T cells.

Some had persistent spike protein in their blood up to 709 days later.

https://t.co/Gb64TyCz9Z

[Esteban Finol, MD, DSc @MiceDoctor]

The manuscript also fails to bring PACV syndrome in its right perspective. Saying "a small fraction of individuals" or "some individuals have reported post-vaccination symptoms" is too vague. What is the prevalence? Out of the 13 billion doses of COVID19 vaccines.

[Esteban Finol, MD, DSc @MiceDoctor]

@MBlokesch kudos to all the authors. Molecular epidemiology at its best!!

[Esteban Finol, MD, DSc @MiceDoctor]

@AdrianoAguzzi They should do the same for some vacant department head positions.

[Esteban Finol, MD, DSc @MiceDoctor]

@Nicole_Paulk short term focused management and high management salaries and bonuses are not a good combination.
The management will probably keep their bonuses anyway and move to another company.
Thus the actual business is in being part of the management.

[Esteban Finol, MD, DSc @MiceDoctor]

@RSG_Venezuela @Deliana_Infante Kudos!

[Jeremy Farrar @JeremyFarrar]

Sickle cell gene therapy https://t.co/ulrJxOvrIK

[Esteban Finol, MD, DSc @MiceDoctor]

@deboramarks @ATinyGreenCell From my side, not seeing your name in the Lasker and Nobel prizes on this topic was a big disappointment.
Unfortunately, these prizes are the results of extensive PR within previous-awardees.
Deepmind, by providing easy use of alphafold, made a great PR move in this sense.

[Esteban Finol, MD, DSc @MiceDoctor]

@deboramarks @ATinyGreenCell Dear Debora, I was amazed with the use of MSA and co-evolution of residues to derive protein contacts and protein structure in your much earlier papers. AF and AF2 strongly relied on that concept and I have no doubts that they took the idea from your work.

[Esteban Finol, MD, DSc @MiceDoctor]

@sokrypton @SluskyLab Well, obtaining structural information from co-evolution of residues was the game-changing and main feature of AF and AF2, and originally it was not their idea. I would have included Deborah Marks in the list.

[Esteban Finol, MD, DSc @MiceDoctor]

@Caroline_Bartma @vineethvengayil There is also a patent on this matter
https://t.co/ZAbLeU0i68

[Esteban Finol, MD, DSc @MiceDoctor]

@Caroline_Bartma @vineethvengayil BTW, the 3XUbVR-tag-GOI-mRNA is larger than the GOI-mRNA. The mRNA size matters a lot in delivery efficiency. Hence, I won't rule out that the expected reduction in mRNA delivery explain our results.
The project was dropped to favours other promising projects.