We’re excited to share that PharosAI has selected our Xenium spatial platform to help build a multimodal cancer dataset, an initiative that brings together academic and NHS partners to transform archived cancer samples into high-res, AI-ready data. https://t.co/VQf3ZBu3o4
Could tolerance to DNA be broken in the gut in systemic lupus erythematosus?
In our latest review we explore whether tolerance to DNA can be broken when undigested DNA from microbiota in GALT directly encounters B cells unrestricted by T cell dependence
https://t.co/zAgQyJ1u0E
After leaving the bone marrow, transitional B cells split into subsets w/ biased expression of homing receptors and different surface IgM levels. Spencer & Dionisi @JoSpencerLab discuss how this could contribute to human lymphoid tissue content & function https://t.co/S3tAAx7B2k
Our latest perspective piece is out now in @JExpMed! Here we propose that recruitment of immature B cells could contribute to human lymphoid tissue structure and function.
https://t.co/I6ViZ3SZh7
Lots of amazing work on display at Spatial Biology Research @ King’s symposium, a pleasure for our postdoc @michaeljpitcher to showcase our work with the Spatial Biology Facility, using @nanostringtech CosMX to study B cells in gut lymphoid tissue
@KCLcancer_pharm@JelmarQuist
Proud to joint-author with Lucia Montorsi on this latest paper from our lab, using spatial transcriptomics, imaging mass cytometry and more to investigate feature of autoimmunity present as interacting features of healthy gut
Our latest paper is out now in @NatureComms!
Lucia Montorsi and @michaeljpitcher from our lab and collaborators identified characteristics of autoimmune diseases as normal components of the immune system in human gut:
https://t.co/56aDGlThk2
Our review of the current knowledge of GALT is out now in @TrendsImmuno ! In collab with @BemarkMats, we discuss GALT organisation, B/T cell interactions, responses to microbiota, and links between GALT and autoimmunity https://t.co/ilpRY0IECS
Our review for Trends on the current knowledge of GALT is now out. We discuss its organisation, the role of GALT in B cell development, its role in autoimmunity and T cell help to B cells. Thanks to @JoSpencerLab and @michaeljpitcher for the collaboration. https://t.co/VQm3v83egn
Our new preprint is live on bioRxiv! We identify a link between microbiota, intestinal immunity and autoimmunity using protocols that include a new method to resolve spatial transcriptomics to single cells
https://t.co/os8LKIyeqA
Our letter, "Heritable diversity in the human antigen inexperienced B cell repertoire", is out now in Molecular Immunology! We show TS & naïve B cells have more similar gene expression if they are from the same clone @michaeljpitcher
https://t.co/3HogB0nYFa
Happy that a review written together with @JoSpencerLab human on gut inflammation and B cells is now out in @NatRevGastroHep. In it we discuss induction of gut responses, tissue sampling problems, and changes during IBD, coeliac disease and autoimmunity. https://t.co/Vwz7EqxGPi
@se_railway I've tried to purchase a weekly ticket, the payment went through from my bank but there's no sign of the ticket and I get "An error occurred" message
Open access to our latest paper is available through our group page:
https://t.co/0mnzYu6raH
Click the link under "Human B cells in tissues" in the Projects section
Super excited to share that our work about human marginal zone B cell heterogeneity in lymphoid tissues and its implications in lupus is now published in @SciImmunology. Huge thanks to @Gates_Cambridge and @CCSF67 for their support. https://t.co/0eClT0DUO8