Michael Pitcher

Active at

[Waggoner Lab @LabWaggoner]

Immunomodulatory B cells in human gut-associated lymphoid tissue support mucosal homeostasis
https://t.co/G5rsP5h5sB @SciImmunology @michaeljpitcher @JoSpencerLab @KingsCollegeLon

[10x Genomics @10xGenomics]

We’re excited to share that PharosAI has selected our Xenium spatial platform to help build a multimodal cancer dataset, an initiative that brings together academic and NHS partners to transform archived cancer samples into high-res, AI-ready data. https://t.co/VQf3ZBu3o4

[Michael Pitcher @michaeljpitcher]

@Se_Railway are any trains running on the Hastings line from London Bridge to Tunbridge wells?

[Jo Spencer Lab @JoSpencerLab]

Could tolerance to DNA be broken in the gut in systemic lupus erythematosus?

In our latest review we explore whether tolerance to DNA can be broken when undigested DNA from microbiota in GALT directly encounters B cells unrestricted by T cell dependence

https://t.co/zAgQyJ1u0E

[Journal of Experimental Medicine @JExpMed]

After leaving the bone marrow, transitional B cells split into subsets w/ biased expression of homing receptors and different surface IgM levels. Spencer & Dionisi @JoSpencerLab discuss how this could contribute to human lymphoid tissue content & function https://t.co/S3tAAx7B2k

[Jo Spencer Lab @JoSpencerLab]

Our latest perspective piece is out now in @JExpMed! Here we propose that recruitment of immature B cells could contribute to human lymphoid tissue structure and function.
https://t.co/I6ViZ3SZh7

[Michael Pitcher @michaeljpitcher]

@FranciCapon @UBCmedicine @BCCHresearch @CMMT_UBC Congratulations!!

[Jo Spencer Lab @JoSpencerLab]

Lots of amazing work on display at Spatial Biology Research @ King’s symposium, a pleasure for our postdoc @michaeljpitcher to showcase our work with the Spatial Biology Facility, using @nanostringtech CosMX to study B cells in gut lymphoid tissue

@KCLcancer_pharm @JelmarQuist

[Michael Pitcher @michaeljpitcher]

Proud to joint-author with Lucia Montorsi on this latest paper from our lab, using spatial transcriptomics, imaging mass cytometry and more to investigate feature of autoimmunity present as interacting features of healthy gut

[Jo Spencer Lab @JoSpencerLab]

Our latest paper is out now in @NatureComms! 

Lucia Montorsi and @michaeljpitcher from our lab and collaborators identified characteristics of autoimmune diseases as normal components of the immune system in human gut:

https://t.co/56aDGlThk2

[Michael Pitcher @michaeljpitcher]

New review of GALT and B cells from our lab and @BemarkMats is out now in @TrendsImmuno !

[Jo Spencer Lab @JoSpencerLab]

Our review of the current knowledge of GALT is out now in @TrendsImmuno ! In collab with @BemarkMats, we discuss GALT organisation, B/T cell interactions, responses to microbiota, and links between GALT and autoimmunity https://t.co/ilpRY0IECS

[Mats Bemark @BemarkMats]

Our review for Trends on the current knowledge of GALT is now out. We discuss its organisation, the role of GALT in B cell development, its role in autoimmunity and T cell help to B cells. Thanks to @JoSpencerLab and @michaeljpitcher for the collaboration. https://t.co/VQm3v83egn

[Trends in Immunology @TrendsImmuno]

Gut-associated lymphoid tissue: a microbiota-driven hub of B cell immunity https://t.co/22FtHlMiaN #immunology

[Michael Pitcher @michaeljpitcher]

New preprint from our lab out now!

[Jo Spencer Lab @JoSpencerLab]

Our new preprint is live on bioRxiv! We identify a link between microbiota, intestinal immunity and autoimmunity using protocols that include a new method to resolve spatial transcriptomics to single cells
https://t.co/os8LKIyeqA

[Jo Spencer Lab @JoSpencerLab]

Our letter, "Heritable diversity in the human antigen inexperienced B cell repertoire", is out now in Molecular Immunology! We show TS & naïve B cells have more similar gene expression if they are from the same clone @michaeljpitcher

https://t.co/3HogB0nYFa

[Jo Spencer Lab @JoSpencerLab]

Massive congratulations to Bekki Velounias, who successfully defended her PhD thesis today!

[Mats Bemark @BemarkMats]

Happy that a review written together with @JoSpencerLab human on gut inflammation and B cells is now out in @NatRevGastroHep. In it we discuss induction of gut responses, tissue sampling problems, and changes during IBD, coeliac disease and autoimmunity. https://t.co/Vwz7EqxGPi

[Michael Pitcher @michaeljpitcher]

@se_railway I've tried to purchase a weekly ticket, the payment went through from my bank but there's no sign of the ticket and I get "An error occurred" message

[Jo Spencer Lab @JoSpencerLab]

Open access to our latest paper is available through our group page:
https://t.co/0mnzYu6raH
Click the link under "Human B cells in tissues" in the Projects section

[School of Immunology & Microbial Sciences @KCLImmunoMicro]

🔬Newly published in @SciImmunology, by @JoSpencerLab's @JQ_Siu, @michaeljpitcher, @Thomas_J_Tull & others:

Deep analysis reveals new insights into B cells and the role they play in disease. Find out more ⤵️
https://t.co/tQ56VTMSQy

[Michael Pitcher @michaeljpitcher]

Latest paper from our lab @JoSpencerLab is out now in @SciImmunology! Pleased to have contributed to this work by fantastic @JQ_Siu and collaborators

[Jacqueline HY Siu @JQ_Siu]

Super excited to share that our work about human marginal zone B cell heterogeneity in lymphoid tissues and its implications in lupus is now published in @SciImmunology. Huge thanks to @Gates_Cambridge and @CCSF67 for their support. https://t.co/0eClT0DUO8