Luke Turner 🦠

Clinical Scientist (HSST) @PublicHealthW - Microbiology. Focusing on #AMR and WGS 🧬 Own opinion only. Fictional cases for education #AMStewardship #MedEd

[Luke Turner 🦠 @MicroLukas]

A potentially useful table for anyone interested in understanding the recommended usage of some of the newer antibacterials, e.g. latest beta-lactam/inhibitor combinations.

#AMR #AMS

[Luke Turner 🦠 @MicroLukas]

@kh505043 Yes 💪

[Luke Turner 🦠 @MicroLukas]

Q: Which Staphylococcus aureus toxin is responsible for toxic shock syndrome?

A. Exfoliative toxin
B. TSST-1
C. Staphylococcal enterotoxin A
D. Haemolysin

[Luke Turner 🦠 @MicroLukas]

@farhadparv27723 💯

[Luke Turner 🦠 @MicroLukas]

@Dr_Shiv_kumar_ 🏆 Bingo

[Shaula @cr0nch_noodle]

@mathladyhazel yeah math jokes have to at least work

[Luke Turner 🦠 @MicroLukas]

It combines cefepime’s activity against penicillin-binding protein 3 (PBP3) with zidebactam’s selective inhibition of penicillin-binding protein 2 (PBP2).

[Luke Turner 🦠 @MicroLukas]

FDA approves cefepime/zidebactam (zaynich) for complicated urinary tract infections (cUTIs), including pyelonephritis 🎉

https://t.co/dLq63XPdbh

[S.Enf.Infecciosas HRUM @infeccHRUmalaga]

Buenas noticias!!! 🎉🥳📰 @US_FDA🇺🇸 APRUEBA #Cefepime/ZIDEBACTAM✅ en #ITUcomplicada 🚽
👉🏻SUPERIORIDAD 🆚 #meropenem en Ens Clin F3 #ENHANCE-1 🥇
👉🏻Antibiótico de amplio espectro incluyendo #KPC, #OXA48 y #MetaloBlactamasas (VIM, NDM,IMP)
@pharmacally 🆓🔗https://t.co/QQwpBwskeN

[Luke Turner 🦠 @MicroLukas]

Mycobacterium leprae ✅

Extremely slow 🦥

Estimated doubling time: ~12-14 days

Cannot be cultured in standard artificial media

Requires intracellular growth in host tissues (e.g., Schwann cells)

[Luke Turner 🦠 @MicroLukas]

Which of the following has an extremely slow doubling time of ~12–14 days? ⏰

[Luke Turner 🦠 @MicroLukas]

Yersinia pestis ❌

Intermediate-fast grower

Doubling time: ~1-2 hours

Grows well on standard media (e.g., blood agar, MacConkey)

Slower than Clostridium perfringens but still a relatively rapid pathogen compared with most bacteria

[Luke Turner 🦠 @MicroLukas]

@StephenTristram Absolutely. They're an incredibly diverse group.

[Luke Turner 🦠 @MicroLukas]

A neonate presents with meningitis at your hospital.

CSF grows a bacteria with a propensity for abscess formation.

You recommend contrast-enhanced MRI as a result.

Which organism have you seen?

[Luke Turner 🦠 @MicroLukas]

The answer here is Citrobacter koseri.

Why? Because it has a well-known propensity for causing brain abscesses in neonates - far more than most other neonatal meningitis pathogens.

But why isn't the answer K. aerogenes....🧐👇

[Luke Turner 🦠 @MicroLukas]

A neonate presents with meningitis at your hospital.

CSF grows a bacteria with a propensity for abscess formation.

You recommend contrast-enhanced MRI as a result.

Which organism have you seen?

[Luke Turner 🦠 @MicroLukas]

Importantly, manifestations often emerge in the second week of illness.

New focal neurology or seizures in neonatal meningitis should prompt imaging for abscess formation.

[Luke Turner 🦠 @MicroLukas]

Clinical clues suggesting abscess formation:
• Persistent fever
• Rising CRP/inflammatory markers
• Bulging fontanelle
• Increasing head circumference
• Focal seizures
• Hemiparesis
• Poor response to antibiotics

[Infected Terran, MD @Infected_Terran]

@BJegorovic @BradSpellberg @DrToddLee @venkat_id @IDiots_pod @ABsteward @JamesWilsonDO1 @CosEpiID I will tell you what I tell the residents. If you're going to swab a sacral wound, you may as well stick the swab directly into the rectum. The result will be equally informative. This also applies to foot wounds.