Michele Schlich

Drug and gene delivery scientist at @univca and @iitalk

[Alnylam Pharmaceuticals @Alnylam]

RNAi therapeutics target disease at its roots rather than just treating symptoms. Based on Nobel Prize-winning science, these genetic medicines silence disease-causing genes before unwanted proteins are made.

5 key facts: https://t.co/Iidk14A2Ah

#RNAi #GeneticMedicine

[CRS Italy Local Chapter @CRS_Italia]

We are happy to #release the announcement of the next @CRS_Italia workshop! Join us in sunny #Bari on May 15th-17th for intense days of science and networking. Discover this year's theme & invited speakers, and register at https://t.co/0BpMrEkaZm @CRSScience @CRS_YSC

[Next Generation Chemists 2024 @NextGenChem24]

After 9+ months of meetings and organisation, we finally gave birth to the Next Generation Chemists 2024 Conference! It was amazing!!!
We are looking forward to meeting you at the next edition #NGC26 @UNICA
***********
#NGC24 #SCI #Societ��ChimicaItaliana #ChemistryIsEverywhere

[Dr Haiyan Zhou @lab_zhou]

An exciting Research Assistant position in the Zhou Lab on RNA drug development. here is the applicaiton link: https://t.co/ToERAl07Rt
Application deadline 20th Oct 2024. Please do help circulate it.

[Michele Schlich @MicSchlich]

New piece on #microfluidics parameters for #liposome fabrication, with #moleculardynamics insights by @mpannuzz @AstraZeneca. Check it out to see how flow rate ratios and post-production dilution impact the encapsulation of lipophilic drugs💊.
@univca https://t.co/Iqxv1yTUIg

[CRS Italy Local Chapter @CRS_Italia]

Happy faces of the full Italy chapter board at #CRS2024: an intense week of inspiring science and meeting opportunities with old and new friends. We are happy to have supported 35 young scientists with travel grants to take part in this brilliant event @CRSScience @CRS_YSC

[CRS Italy Local Chapter @CRS_Italia]

In diretta dal #SimposioAFI @afiscientifica! Passate a trovarci per conoscere le nostre attività, tra cui l’iniziativa #ESTRUM dedicata ad università ed aziende

[Michele Schlich @MicSchlich]

Hot off the press 🗞️: Polyphosphoester-stabilized cubosomes encapsulating a Ru(II) complex for the photodynamic treatment of lung adenocarcinoma. A truly collaborative effort! 💡🧫@LucaConti_Chem @MarcoFornasier @FrederikWurm #sergiomurgia #claudiagiorgi https://t.co/IIiSsgjMyb

[Oligonucleotide Therapeutics Society @OTSociety]

FDA Approved the First CRISPR Treatment – Potential Cure for People with Sickle Cell Disease ⬇️

https://t.co/cKhVHB2lOB

#ots #oligotherapeutics #scd #sicklecelldisease #fda #casgevy #lyfgenia #genetherapy #CRISPR #pharmaceuticals #medicine #currentresearch #science

[AndreaPorcheddu @Porcheddu_UNICA]

Are you interested in organic synthesis? We have a post-doc position available in our mechanochemistry group. The position is based in a beautiful location in Cagliari. If you're interested, please send your CV to me privately.

Take advantage of a one-of-a-kind opportunity!

[Emilia Paone @EmiPao90]

Merry Christmas to all believers 🎄✨🎅🏼
#oldbutgold

[Michele Schlich @MicSchlich]

@tlmoore_BioNano @DeptPharm_Unina @UninaIT @ClemsonBIOE @MerkleInstitute @AMIBioNano @iit Great news my friend, congratulazioni ! 🥂

[Michele Schlich @MicSchlich]

@MarcoFornasier @Fysiografen1772 Well deserved Marco, congrats!

[CRS Italy Local Chapter @CRS_Italia]

Don't miss the next @CRSScience Local Chapter webinar next week (November 16, 2023): a targeted dose of #drugdelivery science provided by @CRS_GermanChapt 🇩🇪 and @CRS_Italia 🇮🇹.
Link for registration: https://t.co/ymkbBSLJ6r

[CRS Italy Local Chapter @CRS_Italia]

Closing remarks from the president #stefanosalmaso and local chair #fabiopalumbo “As @CRS_Italia community, we are one branch of a big tree”. Thanks to all the attendees, the speakers and the sponsors, see you in Bologna #CRS2024! @CRSScience @CRS_YSC

[CRS Italy Local Chapter @CRS_Italia]

It’s time for RNA & protein delivery session 🧬 Inspiring talks by #kevinbraeckmans @ugent on laser-based approaches to safely transfect cells, and @VArechavala on the importance of #delivery to traeat #rarediseases in difficult-to-reach tissues @AON_Delivery @CRS_FG_Gene

[Alex Cook @AlexCook222]

Very cool to see this previous project from Italy @IITalk @pgdecuzzi on the inside cover of @RSCApplied Polymers first issue! Article here: https://t.co/dtmhxUp9q4

[Justin Hanes @JustinHanesPhD]

Here are the top ten answers (for me) to the most important question we should ask ourselves everyday… a thread 🧵 #CRS2023
@CRSScience
Retweet = follow!
Please add your own thoughts and retweet!
Thank you 🙏🏼

[Veera Rajagopal  @doctorveera]

A mind-blowing paper has come out today in @Nature

In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (https://t.co/Rk8oZJ0bUj).

Today, a group of scientists from Indiana University reports how that minimal genome evolved over 2000 generations in comparison to the non-minimal genome.

The authors found that even when you reduce a bacterial genome to its absolute minimum where every nucleotide matters, the genome undergoes mutational events generation after generation as much as the non-minimal genome. One simply cannot stop the evolution.

Just over 300 days of evolution (equivalent to 40,000 years in humans) the minimal cell has gained everything it lacked in fitness on day one in comparison to the non-minimal cell.

When comparing the evolved traits between the minimal and non-minimal cells, the scientists found something striking. The evolutionary process increased the cell size of non-minimal cells but not that of the minimal cell. But that is not the striking part.

The scientists were able to identify the key mutation that resulted in cell size evolution. And it turned out that the mutation that helped the non-minimal cells to grow bigger is the same that helped the minimal cells to stay smaller. Growing bigger had a survival advantage for non-minimal cells and not growing bigger had a survival advantage for minimal cells. So, the mutation had a context-dependent effect. This just demonstrates that the evolutionary effects on traits have no absolute direction. All that matter is what is beneficial for the organism's survival.

The conclusion of the paper is metaphorically a quote from the Jurassic Park movie:

“Listen, if there’s one thing the history of evolution has taught us is that life will not be contained. Life breaks free. It expands to new territories, and it crashes through barriers painfully, maybe even dangerously, but . . . life finds a way". (https://t.co/UlxRlb86CT)

https://t.co/zA9OAqSoAu

[Michele Schlich @MicSchlich]

Aaaaand it’s done! Over 120 plasma samples prepared for HPLC-MS to determine the PK of our liposomal adrenaline🐖���. Simply not possible without the precious help of Alessio, super pre-doc trainee in our lab #REVIVEproject @univca @SardegnaRs