SR ³³

اللهم صلِ وسلم وبارك على نبينا محمد.

[Ahmad Alsabban | أحمد الصبان @DrAhmadAlsabban]

مساء الخير للمستثمرين
في شهر ابريل الماضي بدات تجربة جديدة في عالم (صناديق التوزيعات الشهرية)

# وضعت 200 الف موزعة على
1- صندوق الراجحي للتوزيعات الشهرية
2- صندوق سدكو كابيتال العالمي للتوزيعات الشهرية

بواقع 100 ألف ريال في كل صندوق، مع إعادة استثمار التوزيعات في الصندوق نفسه

بعد مرور 5 أشهر، بلغ إجمالي التوزيعات
الراجحي: 4,018 ريال، بعائد توزيع 4.02%
سدكو: 4,121 ريال، بعائد توزيع 4.12%

ولو استمر متوسط التوزيعات نفسه، فسيكون عائد التوزيع السنوي التقريبي:
9.6% للراجحي و9.9% لسدكو

الراجحي تفوّق في توزيعات يونيو ويوليو، لكن سدكو عاد للتفوّق في أغسطس، ولا يزال متقدمًا في إجمالي التوزيعات منذ بداية التجربة

ونتابع مع الوقت أثر إعادة استثمار التوزيعات على نمو الدخل الشهري

ملاحظة: المقارنة هنا لعائد التوزيعات على رأس المال الأصلي، وليست للعائد الكلي الذي يشمل أيضًا تغيّر قيمة الوحدات

[؏ــبــدﷲ[حكاية عطرية] @l1h1b]

اسبيراشن حق الكسائي بطل جداً وأنيق بشكل ملفت

سلك
بارد وانسيابي
شبابي بإمتياز
وممتاز في مقاومة التكسر

[Malachy @MyProtocols]

Androsterone on my forearms, Pansterone in my belly button, Kuinone on my balls...

HOLY FUCKING SHIT!

[Lawrence | SwolLyfe @_TrueVoodoo]

Been on a mission to heal my gut and improve my microbiome and so this is what my morning supplement routine looks like in addition to @revivosupps, goBHB, and a glass of kiefer.

[Hans Amato @HansAmato]

It's almost a waste to take pregnenolone without PEA.

It's almost a waste to take PEA without pregnenolone.

A lot of what people want from pregnenolone doesn't come from pregnenolone itself. It comes from allopregnenolone. The conversion product. Allopregnenolone is what gives you the calming, sleep-improving, stress-buffering effects. That's the molecule people are actually chasing.

PEA upregulates 5-alpha reductase.

That's the enzyme that converts pregnenolone into allopregnenolone.

Without enough 5-alpha reductase activity, your pregnenolone doesn't convert efficiently.

Instead it sits there as pregnenolone, which is more stimulating, or gets shunted down a different pathway entirely.

That's why some people take pregnenolone and feel wired instead of calm. Agitated instead of relaxed. They have the precursor. They're missing the conversion.

The other direction: if you take PEA alone, you're upregulating an enzyme that has nothing to convert. You need enough pregnenolone in the system for 5-alpha reductase to have a substrate. PEA opens the door. Pregnenolone walks through it.

Together: pregnenolone supplies the raw material. PEA ensures it becomes allopregnenolone instead of something else.

[Bo English @BOENGLISH1]

Nattokinase 10k units a day, everyday. Will retest labs in a month and see if it’s done anything. I’ve been running different brands, different variations but the research looks solid on Nattokinase

[؏ــبــدﷲ[حكاية عطرية] @l1h1b]

شيكيبو 110 عندهم بطل جداً للمناسبات والرسميات وحتى للدوام المكتبي

١٠٪ توفسيل
نص وقفة
خامة يابانية فاخرة تكد ولاتبيد👌🏻

الثانية / سوبر رويال 60
يومي بارد
ربع وقفة
مريح جداً وبطل في مقاومة التكسر

[Jaffar✨ @jaffar_45]

في وظيفتي الاولى مامر عليي احد استخدم هذا الدواء، في المكان الجديد تقريبًا ٤ عملاء مروا عليي يستخدموه

يستخدم لحالتين:
- الامساك المزمن اللي مو معروف سببه
- ومتلازمة القولون العصبي مع الامساك

عمله يزيد إفراز السوائل في الأمعاء، بالتالي يليين البراز ويعزز حركة الأمعاء المنتظمة

[Little Way Health Coach @biohackingdad]

Why are you not making S. Boulardii juice??

Crack a cap into organic grape and let sit for 48 hours.

I like to drink 1/2 cup a day.

[Hans Amato @HansAmato]

Vit E is great for lowering prolactin.

I used 800IU of TocoVit vitamin E daily for 30 days and my prolactin dropped from 8.5 to 2.2.

My prolactin wasn't elevated so it will work even better for someone with high prolactin.

I like TocoVit as it contains lots of alpha-tocopherol, which is responsible for lowering prolactin. It's also a great source of policosinols.

[Dr. David @DrDavidivw]

🚨 Prostate Cancer Disappears After Taking Fenbendazole

In 2019, a man was diagnosed with prostate cancer and scheduled for surgery. Due to COVID, his surgery was delayed until the summer of 2020.

In February, he started taking Fenbendazole (commonly known as a dog dewormer).

By the time his surgery date arrived, doctors could no longer find any cancer.

His PSA levels had dropped from 11 to between 3 and 4. He canceled the surgery.

It’s now been over five years since his diagnosis, and the cancer has not returned. He stopped taking Fenbendazole in 2022.

He later wrote a book about his journey called “Finding Fenbendazole” by Roger Rasmussen, which includes science-backed information for those facing cancer.

Interestingly, his brother was also diagnosed with prostate cancer in 2022.

After following a Fenbendazole and Ivermectin protocol, his PSA levels returned to normal, and doctors could no longer detect the cancer.

Stories like this continue to fuel interest in repurposed drugs like Fenbendazole and Ivermectin in cancer care.

Access high-quality Ivermectin and Fenbendazole from
@DrDavidivw , Worldwide delivery with 24/7 Live human support.

[Ryan Ayala @RyanJAyala]

How to fix your gut, in order:

1. Fix your stomach acid
2. Patch the lining (zinc carnosine + glutamine), 4-8 weeks
3. Feed the gut cells (butyrate)
4. Break up the biofilm (NAC), 3-6 weeks
5. Kill the bad bacteria

Start with probiotics and you just feed the bad bacteria

[Dr. Bruce Allan MD @Dr_BruceAllan]

An increased dose of ivermectin is definitely working and making her Herx. She will know soon what her next step is.

That’s usually a sign the ivermectin is hitting something and the body is reacting to the die-off.

My advise to anyone using IVERMECTIN
Make sure you’re using a binder, when parasites die they release toxins and lay a bunch of eggs, a binder helps the toxins stick to it and flush them out or you’ll get detox headaches from all the toxic waste.

Stay hydrated as well and monitor how intense the Herx reaction gets.

[Sefa Uygun @sefauygunn]

Yakında PEA (palmitoylethanolamide) takviyesi fazlasıyla konuşulacak.

Çünkü şimdiye kadar denediğim en güçlü, işe yarar ve aklınıza gelebilecek çoğu durumda potansiyel faydası olan bir bileşik.

PEA, vücuda tamamen yabancı sentetik bir madde değil.

Beyinde, sinirlerde, bağışıklık hücrelerinde ve birçok dokuda bulunan; hücresel hasar, ağrı ve inflamasyon oluştuğunda hücre zarındaki yağlardan ihtiyaç üzerine üretilen doğal bir lipid habercisidir.

PEA’nın araştırıldığı potansiyel kullanım alanları inanılmaz geniş:

• Kronik ve nöropatik ağrı
• Diyabetik nöropati, yanma, batma ve uyuşma
• Siyatik ve bel kaynaklı sinir ağrısı
• Radikülopati ve sinir sıkışmaları
• Kemoterapiye bağlı sinir hasarı
• Osteoartrit ve eklem ağrısı
• Çene eklemi ağrısı
• Fibromiyalji ve merkezi duyarlılaşma
• Migren ve kronik baş ağrısı
• Kronik prostatit/kronik pelvik ağrı sendromu
• Endometriozis ve kronik pelvik ağrı
• Regl ağrısı, disparoni ve vulvodini
• IBS’ye eşlik eden karın ağrısı
• Mast hücresi aktivasyonu ve histamin kaynaklı belirtiler
• Alerjik yakınmalar, kaşıntı ve egzama
• Uykuya dalma güçlüğü ve sabah sersemliği
• Depresif belirtiler ve strese karşı dayanıklılık
• Anksiyete ve nöroinflamasyona bağlı duygu durum sorunları
• Hafıza, BDNF ve bilişsel performans
• Egzersize bağlı kas hasarı ve toparlanma
• Üst solunum yolu enfeksiyonlarının sıklığı ve şiddeti
• Enfeksiyon sonrası koku kaybı ve nöroinflamasyon

Benim önerdiğim deneme protokolü:

İlk 3–4 gün: akşam 300 mg
-Sonraki 7 gün: sabah 300 mg + akşam 300 mg
-Belirgin fayda yok ama tolerans iyiyse: sabah 600 mg + akşam 600 mg

Bu dozu 4–8 hafta değerlendir.
Fayda oturduğunda idame: 300–600 mg/gün

[limitlesstack @limitlesstack]

Vesugen just officially dropped (aka Russian Cialis) and it should have you kind of excited in more than one area

unlike Cialis, Vesugen works epigenetically. your body will keep the benefits months after you stop taking it.

some of the findings are just nuts:

one cycle (30 days) of oral Vesugen increased peak systolic blood flow velocity in the major penile arteries by a ridiculous 53-61% versus controls

FIFTY THREE
TO
SIXTY ONE
FUCKING PERCENT
HIGHER BLOOD FLOW VELOCITY

but the penis side of things is just a bonus.

your endothelium, the thin layer of cells lining every blood vessel in your body, is approximately 7 trillion cells covering 60,000 miles of vasculature.

your body barely replaces these cells. in adult vasculature, endothelial cells often persist for years before being replaced.

Vesugen directly acts on these cells.

- restores function in aging endothelial cells
- shifts senescent endothelial cells back toward a more proliferative state
- supports endothelial repair and regeneration
- improves communication between endothelial cells
- reduces excessive vasoconstrictive signaling from dysfunctional endothelium
- restores blood vessel growth and repair signaling

how i cycle it:

- 2 oral Vesugen tablets daily (2mg total)
- taken on an empty stomach
- 30d on, 60d off

take with Vilon for a fucking amazing preworkout

the only oral brand that is actually dosed properly:

US domestic Vesugen: https://t.co/mHlk8eMaV8

EU domestic Vesugen: https://t.co/uwuY9AVgwq

UK domestic Vesugen: https://t.co/GgqISiMCWU

not medical advice.

[Life Pill 💊 @life__pill]

How to fight erectile dysfunction in 30 days:

1. Walk 8,000 steps every day - blood flow is the fix
2. Eat beetroot or drink beetroot juice daily
3. Take L-Arginine 3g every morning
4. Stop porn - dopamine system needs to reset
5. Cut alcohol - it is a vascular destroyer
6. Squats 50x daily - raises T and pelvic circulation
7. Zinc 25mg + Vitamin D3 3,000 IU daily
8. Sleep 8 hours - erections are built overnight
9. Panax Ginseng 600mg - clinically proven for ED
10. Lose 1kg of belly fat - fat converts T to estrogen

30 days.
No prescription needed.
Just discipline.

[Zygomatic @Zygomatic03]

Why will this stack have your foid begging for more?

Tadalafil - the ultimate bonermaxxing drug, better erections, lower refractory period (go again sooner), vascular health & blood pressure benefits

Vitamin K2 MK4 - helps prevent calcium buildup in arteries for better circulation and hardness downstairs, supports healthy test levels in animal studies. Potent, short half life, adds extra stiffness, can apply topically too

Aspirin - studies have likened effects to viagra, thins blood and improves circulation. Wide range of other cardiac and metabolic benefits, cheapest drug around. A gram is extreme, even a small dose (~80mg) can be supportive for your pecker

Is this the Holy Trinity of Dickmaxxing supplements?

[Hans Amato @HansAmato]

Bumped my pregnenolone to 300mg just to get my allopregnanolone into range. It worked, but something bothered me about needing that much just to hit a normal number.

Dropped back to 100mg. Added PEA instead. If PEA actually raised the enzyme doing the conversion, allopregnanolone should hold steady even on a third of the dose.

It didn't just hold steady. It nearly doubled.

[Hans Amato @HansAmato]

Why is nobody talking about how just 600mg PEA per meal can double allopregnanolone (one of the most powerful anti-anxiety and anti-depressive neurosteroids) in just 14 days.

[George Ferman @Helios_Movement]

Should you supplement with pregnenolone and DHEA?

Because you might pay attention to hormones such as testosterone, insulin, T3, T4, estrogen, progesterone, cortisol and so on, but if you don’t pay attention to pregnenolone and DHEA, you can still struggle with:

-Chronic inflammation
-Fatigue
-Low libido
-Cognitive problems
-Mood problems (low-grade depression, anxiety etc)
and much more.

If you are skeptical, keep in mind that low brain and plasma levels of pregnenolone for example are consistently found in major depression, bipolar depression, schizophrenia, PTSD, autism spectrum disorders and cannabis withdrawal.

Now pregnenolone is often reffered to as the “Mother Hormone” and is a steroid hormone produced mainly in the adrenal glands, but also in the brain, gonads, skin and even retina.

Its chemical name is 3beta-hydroxypregn-5-en-20-one, a 21-carbon delta-5 steroid with a hydroxyl group at position 3 and a ketone at position 20.

Why is it referred to as the mother hormone?

Because it is the single molecule from which every steroid hormone in the human body is ultimately derived.

Now here’s how pregnenolone is synthesized.

Once again, everything begins with cholesterol.

The rate-limiting step is the transport of cholesterol from the outer to the inner mitochondrial membrane, a process mediated by the Steroidogenic Acute Regulatory protein (StAR (gene STARD1)).

Once inside the mitochondrion, the side-chain cleavage enzyme CYP11A1 (P450scc) removes six carbons from cholesterol using three molecules of oxygen and three NADPH to yield pregnenolone and isocaproaldehyde.From pregnenolone, two major branches diverge:

Δ5 pathway:Pregnenolone → 17α-hydroxypregnenolone (via CYP17A1 17α-hydroxylase activity) → DHEA (via CYP17A1 17,20-lyase activity, strongly stimulated by cytochrome b5).

Δ4 pathway:Pregnenolone → progesterone (via 3β-hydroxysteroid dehydrogenase, HSD3B2) → 17α-hydroxyprogesterone → androstenedione → testosterone, or further to cortisol and aldosterone.

In the brain and peripheral nerves, pregnenolone is rapidly reduced by 5α-reductase type 1 and then 3α-hydroxysteroid dehydrogenase to form allopregnanolone and pregnanolone, two of the most potent positive allosteric modulators of GABA-A receptors known.

If we are healthy (and young), we synthesize roughly 35–50 mg of pregnenolone per day.

Surprisingly, the brain produces almost as much de novo as the adrenal glands (15–20 mg/day each), with smaller contributions from gonads, skin, retina, and placenta during pregnancy.

Brain synthesis is largely independent of peripheral cholesterol pools and continues even in Addison’s disease.

Acute regulation is handled by ACTH and LH, which phosphorylate StAR within minutes.

Chronic regulation depends on the orphan nuclear receptors SF-1 (stimulatory) and DAX-1 (inhibitory), as well as local cytokines, insulin, and IGF-1.

1) Pregnenolone sulfate and allopregnanolone are among the most abundant neurosteroids in human cerebrospinal fluid.

They potentiate both synaptic and extrasynaptic GABA-A receptors (especially δ-subunit-containing receptors), producing benzodiazepine-like anxiolysis WITHOUT tolerance.

They also weakly antagonize NMDA receptors at higher concentrations.

2) Pregnenolone upregulates myelin basic protein and proteolipid protein expression and promotes oligodendrocyte precursor differentiation.

3) It stabilizes neuronal microtubules by binding microtubule-associated protein 2 (MAP2) and increases acetylcholine release in the hippocampus.

4) Pregnenolone inhibits TLR4 signaling and microglial activation in the spinal cord, yielding analgesic effects in chronic low-back pain and fibromyalgia trials.

Now aging causes a 60–70 % decline by age 75 through reduced StAR and CYP11A1 expression.

Also, chronic stress diverts pregnenolone toward cortisol at the expense of DHEA and progesterone (“pregnenolone steal” is an oversimplification, but the ratio shift is real (chronic stress dysregulates the hypothalamic-pituitary-adrenal (HPA) axis, leading to imbalances where cortisol rises while pregnenolone, DHEA, or other downstream hormones decline)).
Because it sits at the very top of the cascade, pregnenolone is shunted toward whichever downstream hormone is most needed.

Then, statins, severe caloric restriction, hypothyroidism, sleep deprivation, long-term SSRI use, and high-dose opioid therapy all lower levels significantly.

So before supplementing with pregnenolone (if you choose to supplement start with a dose as little as 10mg and increase the dose only after 10-14 days if you don’t notice anything)) go and test your free and sulfated levels.

Then, if your levels come back low, address the negative factors that were just mentioned.
Now if you choose to supplement and experience insomnia, irritability, headache, or oily skin and even scalp hair shedding, stop.

If you, on the other hand experience:
-Improved resilience to stress, less anxiety, and depression
-Improved sleep quality
-Improved memory recall
-Improved libido
-Improved energy levels
and your blood work is fine, then you are using the right dose.

Now when it comes to dehydroepiandrosterone (DHEA), it is an androgen that primarily functions as a prohormone produced primarily by the adrenal glands (specifically in the zona reticularis (the innermost layer of the adrenal cortex)), with smaller amounts synthesized in the gonads (ovaries and testes) and brain.

It plays a role in various physiological functions such as:

-Enhancing insulin sensitivity by upregulating glucose transporter 4 (GLUT4) expression in adipocytes and skeletal muscle, plus modulating leptin signaling.

-Promoting fat breakdown by stimulating lipolysis in adipose tissue.

-Supporting energy expenditure by enhancing mitochondrial function and thermogenesis, increasing RMR (resting metabolic rate).

-Promoting osteoblast proliferation and inhibiting osteoclast activity.

-Contributing to the production of allopregnanolone, a neurosteroid that modulates GABA receptors, promoting stress resilience and mood stability.

-Enhancing thyroid hormone activity by improving thyroid receptor sensitivity and supporting T3/T4 conversion.

-Acting as a cortisol antagonist by inhibiting 11β-HSD1.

-Modulating estrogen levels through its conversion to estrone and estradiol.

-Enhancing dopamine synthesis and release.

-Promoting synaptic plasticity and supporting neurogenesis.

-Enhancing T-cell proliferation and natural killer (NK) cell activity

DHEA exists in two forms in the body:

-DHEA: The free form, which is biologically active.
-DHEA-S (DHEA sulfate): A more stable, sulfated form that serves as a reservoir for DHEA and is more commonly measured in blood tests due to its longer half-life.

Now for DHEA to be synthesized, cholesterol is converted into pregnenolone by the enzyme P450scc (cholesterol side-chain cleavage enzyme) in the mitochondria of adrenal cells.

Pregnenolone is then converted to 17α-hydroxypregnenolone by the enzyme 17α-hydroxylase and 17α-hydroxypregnenolone is then transformed into DHEA by the enzyme 17,20-lyase.

It is regulated by adrenocorticotropic hormone (ACTH) from the pituitary gland, which stimulates the adrenal glands.

First consider the following natural ways of boosting DHEA before supplementing with DHEA:

Number 1: Upregulating StAR.
This is a protein that facilitates the transport of cholesterol from the outer to the inner mitochondrial membrane in steroidogenic cells such as the adrenal glands or gonads.

This is the rate-limiting step in steroid hormone synthesis, including DHEA.

In order to do this, avoid herbicides such as glyphosate that are now known to have a negative impact on it.

Consider consuming cholesterol rich foods, chrysin rich food such as quality raw honey, COX-2 inhibitors such as glycine, vitamin E and apigenin rich foods such as chamomile, things that can reduce DAX-1 such as chamomile once again, selenium, retinol and vitamin K2.

Number 2: Lower stress/manage cortisol.
Under stress, the adrenal glands prioritize cortisol production, diverting pregnenolone away from DHEA synthesis.
This can lead to high cortisol and low DHEA levels, a common pattern in chronic stress or HPA axis dysregulation.

For starters in regards to these, go to bed since just one night of sleep deprivation increases cortisol by 21% (and even 50% in some cases), don’t skip breakfast, get sunlight and enough B5, C, zinc, magnesium, sodium and potassium (B5 for example is needed to make coenzyme A and under stress, the adrenal glands dumb A LOT of vitamin C).

Number 3: Fix your circadian rhythm.
All hormones follow a circadian pattern and DHEA is not different.

Number 4: Shilajit and royal jelly use.
Shilajit can boost DHEA by 30% in the span of 3 months and royal jelly increases its conversion to DHEA-S.

After 2-3 months test again.
If your levels are still low you can consider (if you are over 45):
-5mg of DHEA and 10mg of pregnenolone for a month
-10-15mg of DHEA and 20-30mg of pregnenolone if the previous dose does not work.

But once again: DO NOT, start using them without any bloodwork.

More about supplements, peptides etc: https://t.co/XL0eghwaje