Mustafa Khasraw (find me in BlueSky)

Oncologist @DukeU; interested in cancer research, clinical trials, immunotherapy but many other things - Views are my own

[Alireza Mansouri @DrAMansouri]

Wrapping up marathon of 2025 scientific meetings with a great SNO meeting in Hawaii. Presented latest #ctDNA developments in liquid biopsy space. Moderated an outstanding CNS #metastases oral session. Too little site seeing. Looking forward to opening new trials @PennStNeurosurg. Emerging trans-atlantic collaborations! @AsgeirJakola @DuerinckJohnny @cnsmender @mjlimfat @jasia_mahdi @GeurtsMarjolei @MansouriSheila @Kate_chain @MKhasraw @galldiks @NeuroOnc @PennStNeurosurg @BrainTumorDoc

[sina @sinabooeshaghi]

Biology by Biorender, say hello to Biology by Banana.

[Yair Einhorn @yaireinhorn]

I would strongly advise every American leader and policymaker to listen carefully to @davidrliu - the most important scientist and innovator of our lifetime and the person who invented both Base editing & Prime editing - the 2 top leading modalities of Gene editing, when he describes in @60Minutes the grave danger which the American BioTech ecosystem is facing due to insufficient federal funding. America is already losing its technological and innovative edge! $BEAM $PRME

[Journal of Clinical Investigation @jclinicalinvest]

Behind the scenes: Chelsea Railton, Kelly M. Hotchkiss and Kirit Singh @KiritSingh in the lab!

[Journal of Clinical Investigation @jclinicalinvest]

In glioma, T cell immunotherapies are limited by the quantity of available T cells.

@KiritSingh @PeterFecci @MKhasraw & team address this challenge in preclinical models by peripheral injection of autologous T cells after pre-treatment with IL-7.

Full report https://t.co/DYhZkyZywm

[Hussein Tawbi, MD, PhD @HTawbi_MDPhD]

Primary results of RELATIVITY-098 showing that adjuvant nivo+rela does not improve RFS over nivo alone, HR 1.01, biomarker data pointing to value of presence of tumor as a potential requirement for LAG3 blockade to improve efficacy. Neoadjuvant Nivo/rela had >60% MPR

[Bryan D. Choi MD PhD @BryanDChoi]

Congrats @StephenBagleyMD @DrORourke2 and colleagues @PennCancer on their manuscript in @NatureMedicine showing safety and early efficacy of bivalent CAR T cells in 18 patients with recurrent #glioblastoma!
https://t.co/n2QewBy7MZ

[Alireza Mansouri @DrAMansouri]

Honored to be recognized as the Pennsylvania Medical Society Top 40 under 40. Grateful for my patients, colleagues and mentors who inspire me daily to keep pushing for better answers.
@SSMahaseMD
@PennStNeurosurg
@PennStateGME
#Cancer
https://t.co/8ucAhr1z3s

[Mustafa Khasraw (find me in BlueSky) @MKhasraw]

JCI - IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models https://t.co/LJsZ2PCi98 @KiritSingh

[Oded Rechavi @OdedRechavi]

Governments to academia:

[Mustafa Khasraw (find me in BlueSky) @MKhasraw]

A Spatial Multi-Omic Framework Identifies Gliomas Permissive to TIL Expansion https://t.co/cVkMMrkCzG

[Itai Yanai @ItaiYanai]

It's a huge honor to be a part of this truly remarkable set of speakers at the Stand Up for Science rally tomorrow in DC in front of the Lincoln Memorial! (My first speech at this kind of an event!)

[Alireza Mansouri @DrAMansouri]

Check out our latest article in Neuro-Oncology, wherein we outline challenges, lessons learned, and even resources (including protocols) for anyone interested in liquid biopsy studies.
"Hitchhiker’s Guide Toward CSF Biomarkers for Neuro-Oncology" @JeffreyZuccato @MKhasraw @gelarehzadeh @IanParneyMDPhD @MayoClinic @PennStNeurosurg @NeuroOnc https://t.co/opcay5Fhan

[Mustafa Khasraw (find me in BlueSky) @MKhasraw]

Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding: Cancer Cell https://t.co/IEKxdNvx0b

[Mustafa Khasraw (find me in BlueSky) @MKhasraw]

Very proud of you @zz_zhaozhang

[ZZ Zhao Zhang @zz_zhaozhang]

Honored & humbled

[ZZ Zhao Zhang @zz_zhaozhang]

Honored & humbled

[Duke Neurosurgery @Dukeneurosurg]

Anonymous donor gives $50 million to Duke for a proton beam therapy center #protonbeamtherapy
https://t.co/juWO3Nsb78

[Alireza Mansouri @DrAMansouri]

Delighted to share our comprehensive review on leptomeningeal disease now online @NatRevClinOncol
Items covered:
1. Distinct pathogenesis of LMD and how it varies from parenchymal brain metastases
2. How cancer cells metabolically in the CSF and evade immune cells
3. Latest advances (and gaps) in our diagnostic approach
4. Up and coming clinical trials for diagnostics and therapeutics
5. How we can learn from past failed studies to put forth standardized approaches
And much more!

Huge effort by first author and future neurosurgical start @NeuroAhmad
Many thanks to all team members: @debaratibhanja @SahgalArjun @MKhasraw @VivekSubbiah @BettegowdaMDPHD @UMDNsgyChair @BrainTumorDoc
@NeuroOnc @EANSonline50 @NBTStweets @theABTA @BTNcares @WeTrialshub @NSTumorSection
https://t.co/epmnZLS2dn

[Vivek Subbiah, MD @VivekSubbiah]

🚨🥁🥁🥁 Hot off the press! @NatRevClinOncol
🚨 Leptomeningeal Metastatic Disease: New Frontiers and Future Directions - Discover groundbreaking insights into LMD in our latest review.
✅From novel diagnostics to cutting-edge therapies like intrathecal and immunotherapies, we explore the path forward in tackling this challenging condition. ✅With advances in mechanistic science and trial design, there's hope on the horizon for improving patient outcomes. 🌟 #LMDResearch #CancerResearch #NeuroOncology #HopeForPatients #precisiononcology #precisionmedicine
Kudos to @NeuroAhmad @DrAMansouri @BrainTumorDoc for spearheading this work!!!
Many thanks to all co-authors:
@debaratibhanja
@SahgalArjun
@MKhasraw
@VivekSubbiah
@BettegowdaMDPHD
@UMDNsgyChair
@NeuroOnc
@EANSonline50
@NBTStweets
@theABTA
@BTNcares
@WeTrialshub
@NSTumorSection Link:
https://t.co/76XT7Z1ogw