Melanie

PhD student in developmental psychology, focussing on environmental and genetic influences on the wellbeing and life course of autistic people

[Melanie @MMPdeWit]

(9/9) It was a great pleasure working on this with Morgan Morgan, Ilan Libedinsky, Chloe Austerberry, Sander Begeer, @dr_appie, @Gelironald and Tinca Polderman

[Melanie @MMPdeWit]

(1/9) 📣 OUT NOW! 📣

So excited to share that our systematic review and meta-analysis on the autism polygenic score is now published in @JAACAPOpen

https://t.co/w5yMc7MtqA

A (long) thread of our main findings ⤵️

[Melanie @MMPdeWit]

(8/9) To conclude, due to inconsistent associations and limited generalizability, the autism polygenic score does not have clinical utility and should only be applied for scientific purposes. Improvements are needed for a deeper understanding of autism’s polygenic underpinnings

[PGC Consortium @PGCgenetics]

📢Out Now 📢

In a GWAS meta-analysis, @Gelironald and colleagues identified 11 independent genome-wide significant loci associated with age at onset of walking.

in @NatureHumBehav

https://t.co/EppFPJ2b9H

[Prof Angelica Ronald @Gelironald]

Fully funded PhD studentship available! Join our lab investigating genetic and environmental influences on early child behaviour. Gain transferable skills in scientific enquiry, coding, writing, presenting & more, deadline June 15th https://t.co/4zwrbDTga8 RTs appreciated!

[Abdel Abdellaoui @dr_appie]

A review and meta-analysis of studies that assess the relationship between the autism polygenic score and autism diagnosis, and autistic, behavioral and neurobiological traits: https://t.co/rKsIcKKCRl

Led by @MMPdeWit 🧬🧠

[Melanie @MMPdeWit]

@Floris_Huider @YMilaneschi @brenda_penninx @VU_FGB @NTRscience @BBMRINL Amazing work, congrats!

[Yuri Milaneschi @YMilaneschi]

Out now! The profile article of our BIObanks Netherlands Internet Collaboration (#BIONIC) project, a #GWAS dataset of >66,000 🇳🇱 subjects to study the genetic base of #Depression. Big shoutout to @Floris_Huider for his great work on the data and the paper: https://t.co/fhegunTFpj

[Melanie @MMPdeWit]

With many thanks to my amazing team of co-authors
@morganjmorgan @ILibedinsky @ChloAusterberry @SanderBegeer @dr_appie @Gelironald and @tincatwin

[Melanie @MMPdeWit]

📢Our preprint is online! 📢

Systematic Review and Meta-Analysis: Research using the Autism Polygenic Score

https://t.co/MWVtVw7y49

[Melanie @MMPdeWit]

We conclude that the current autism polygenic score is consistently associated with autism diagnostic status and autistic traits, but overlap between autism and other traits and conditions is not, from publications to date, explained significantly by the autism polygenic score.