Does sodium bicarbonate improve kidney outcomes in critically ill patients with shock on vasopressors and metabolic acidosis (pH <7.30)?
🤔 SODa-BIC Trial
Primary outcome (MAKE-30): Death, RRT, or persistent renal dysfunction.
40.2% vs 39.4% P = 0.78
https://t.co/GXFT8siN59
Does finerenone improve renal outcomes in patients with non-diabetic CKD?
✅ A slower annual eGFR decline +0.7 mL/min vs placebo
✅ A 23% RRR in the composite kidney/cardiovascular outcome HR 0.77
✅ A 35.4% reduction in UACR compared with placebo
https://t.co/JLJDVcQHl6
Does finerenone slow eGFR decline in patients with glomerular diseases?
✅In FIND-CKD, finerenone slowed eGFR decline, improving total eGFR slope by 0.73 mL/min year versus placebo.
✅Benefits were greatest in FSGS, with a 1.34 mL/min year
https://t.co/4q6aumHnTg
En hemodiálisis, los β-bloqueadores no dializables (carvedilol, propanolol), comparado a los dializables (metoprolol, atenolol, bisoprolol); se asociaron a ↓~20% el riesgo de un evento cardiovascular mayor
En emulación de ensayo clínico
JASN 2026
10.1681/ASN.0000001147