ASOs can effectively decrease the levels of unwanted proteins in the central nervous system. An ASO silencing the expression of tau is midway through a large Phase 1 trial for the treatment of Alzheimer’s disease! (2/2)
Link to full article: https://t.co/ia1ElcMzwC
In our recent @JCI_insight publication, we utilised multi-modal imaging approaches to demonstrate the unique pharmacological properties of anti-sense oligonucleotides and together with ongoing preclinical work, their therapeutic potential for #Alzheimers seems promising! (1/2)
6 top tips for presenting your research, from winners of the @Vitae_news Three Minute Thesis® competition, including @NAlbargothy. Tip 4: 'Tell a story' https://t.co/nKrtA7aC1t
Congratulations to Dr. Chris Sackmann for successfully defending his thesis and contributing to our understanding of the mechanisms underlying the transmission and propagation of #amyloid-beta, #alpha-synuclein and #TDP-43 in #neurodegenerative#diseases!
@LiU_IMH
#Dementia
A fantastic start to this week with two successful grant applications. Thank you to @HjarF for supporting our dementia research and a warm welcome to @LovisaSIJ who will be joining us as a PhD student this autumn @NAlbargothy. @liu_universitet @LiU_IMH
@HallbeckLab demonstrate that the gap junction protein connexin-32 (Cx32) is centrally involved in the preferential uptake of #Parkinsons-associated alpha synuclein oligomeric assemblies in neurons & oligodendrocytes. Cx32 inhibition blocks a-syn uptake
https://t.co/78KDN8a3nF
A newly discovered mechanism reveals how Parkinson’s disease can spread between brain cells. Harmful protein aggregates can “hitch a lift” with gap junction protein connexin-32 @HallbeckLab#research#Parkinsons https://t.co/Q58SNR90QQ
An excellent presentation delivered by our medical student who passed his pre-clinical project today! He helped develop an organotypic slice model of Lewy body dementia alongside our postdoctoral research fellows @marmoussi and @NAlbargothy. @LiU_IMH @liu_universitet
Despite looking slightly terrified in the picture, it felt amazing to finally present my degree project, and I couldn’t have asked for a better group to work with! Very happy with today!
Congratulations to our Master's student Lovisa for passing her 12-month project and on her excellent presentation. She worked on developing a sensitive diagnostic tool for the early detection of AD! @LiU_EPress @LiU_IMH
It was a great honor to be among these fantastic scientists receiving a Junior Faculty Award at the opening ceremony of #ADPD2019! Excited to present my work on APP function in Symposium 34 on Friday AM!
Very informative talks by Prof. Glenda Halliday on alpha-synuclein and Prof. Patrik Brundin, one of the leading experts on the prion-like transmission of this protein. @adpdnet#Day2
A lovely poster by @Nour_Majbour showing second generation conformation-specific antibodies for alpha-synuclein that may be used as a diagnostic tool for PD. Her work got her into the Stars of Science finale! @adpdnet@HBKUPress#vistherposter
https://t.co/s4Fyf6p74l
Congratulations to my colleague on his excellent presentation and more importantly his findings, which demonstrate a novel pathway for the uptake of alpha-synuclein via the gap junction protein #Cx32. @adpdnet@HallbeckLab@liu_universitet
Day 1 of @adpdnet was full of excellent talks and collaborative opportunities. Symposium 1 on cellular models described #iPSCs in AD research, a #chimeric model to study #microglia, #axonal dysfunction induced by #oligomers, 3D minibrains and #CRIPR in patient derived stem cells.