Jean-Charles Nault

Soignant dans le service d’hépatologie Hôpital Avicenne 93, Centre de Recherche des Cordeliers

[Jean-Charles Nault @NaultJc]

Pulp, Paris 2026

[Jean-Charles Nault @NaultJc]

System of a down, Paris 2026

[Philippe Serve @PhilippeServe06]

Surnommée "La Garbo chinoise", RUAN LINGYU était la star du ciné chinois muet. Grande beauté et immense talent au jeu très moderne. Son chef d’œuvre : "La Divine" (1934). Elle se suicide un an plus tard à 25 ans, victime du harcèlement et des diffamations de la presse à scandale.

[Jean-Charles Nault @NaultJc]

@PhilippeServe06 C est bien quand ça reste mystérieux parfois

[Jean-Charles Nault @NaultJc]

@PhilippeServe06 @Noirchick1 Ouaip c est vrai, c est un peu trop long aussi

[Jean-Charles Nault @NaultJc]

@PhilippeServe06 @Noirchick1 Incredible, Titanic is also a great movie :-)

[Jean-Charles Nault @NaultJc]

@PhilippeServe06 Merci Bergman est tellement un grand réalisateur

[Philippe Serve @PhilippeServe06]

Mon montage-hommage au film d'Ingmar Bergman parmi ses moins connus, LE VISAGE (Ansiktet, 1958) avec Max von Sydow, Ingrid Thulin, Bibi Andersson... J'ai plaqué aux images la musique du concerto n°1 de W.A. Mozart. Si vous aimez, retweetez ! Merci 😀🎞️🇸🇪

[Jean-Charles Nault @NaultJc]

@PhilippeServe06 @RFI Oui tout à fait vraiment des grands créateurs

[Jean-Charles Nault @NaultJc]

@PhilippeServe06 @CatsEyeMuseum Tout à fait d accord à réhabiliter

[The Lancet Gastroenterology & Hepatology @LancetGastroHep]

🆕 Addition of ipilimumab to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma (PRODIGE 81-FFCD 2101-TRIPLET HCC): phase 2 results from a randomised, multicentre, open-label, phase 2–3 trial

https://t.co/OaTmg3H2fr

#GITwitter #LiverTwitter #OncTwitter

[Jakob Nikolas Kather @jnkath]

Our paper "Towards autonomous medical artificial intelligence agents" is out in @Nature today! It was led by @Dykex6 who did the real work here.

We present MIRA, an autonomous AI agent that runs end to end through a clinical patient case. We build it on top of LLMs and provide it with scaffolding, tools, and most importantly, a thorough evaluation against human doctors. We show that our agent can solve a clinical case in a multistep process. It takes the history, orders labs and scans, selects medications, decides on procedures, and triages for admission.

For me the most important part is that we can now benchmark humans against AI for the whole decision pathway, not just the end result. Our evaluation shows very good results, almost no severe errors, these AI agents perform just really well on difficult medical cases.

As we move now to implement this in real clinical routine, and run clinical trials about it, we must first fix the infrastructure in our hospitals (and also ensure we still have access to the underlying LLMs...).

Kudos also to our colleagues from Google and Deepmind who published a very similar study back-to-back with us! (https://t.co/mnCsdMCEyE) We are happy that with <<0.01% of Google's R&D budget we can contribute to this space together.

Thanks to all co-authors, our institutions @UniHeidelberg @tudresden_de and also the great @EricTopol for covering us in his newsletter. Congratulations to Dyke and the whole team!

Full text link: https://t.co/eyzKZYYFSs

[OncoDaily GI @OncoDailyGI]

10 Must-Read Posts in GI Oncology This Week | Second Week of June
This week’s selection covers:

• Pancreatic duct biology and cancer subtypes
• Fostrox plus lenvatinib in advanced HCC
• Host–tumor biomarkers in gastric cancer immunotherapy
• FDA Priority Review of atezolizumab in stage III dMMR/MSI-H colon cancer
• ASTRO pancreatic cancer radiation therapy guidelines
• Circulating microbial DNA in colorectal cancer
• TGFBR1*6A and colorectal cancer risk
• PDAC biomarker detection
• Child-Pugh B HCC
• cfDNA methylation profiling in cholangiocarcinoma

Read more on OncoDaily -> https://t.co/dn6YZNW6Xj

@NelsonDusetti @Erman_Akkus @NaultJc @Adrypasana @MikeChuongMD @coloncancermike @ISMAILIN1978

#GIOncology #OncoDaily

[Jean-Charles Nault @NaultJc]

8/8
Thanks to co-first author Anne Victoire Odent, Claudia Campani, the Paris Liver Cancer Group, and all the contributing centers 🙏

📖 Full paper in @JHEPReports (open access):
https://t.co/reBP7WMXEy
#HCC #livercancer #hepatology #oncology #immunotherapy #realworlddata

[Jean-Charles Nault @NaultJc]

1/8
🧬 New paper out in @JHEPReports!

We investigated clinical predictors of response to atezolizumab–bevacizumab (A/B) in Child-Pugh B patients with advanced hepatocellular carcinoma (#HCC) — a population excluded from trials but common in real-world practice.
🧵 Thread 👇

[Jean-Charles Nault @NaultJc]

7/8
Both radiological response (HR=0.58) and liver function improvement (HR=0.59) were independently associated with reduced mortality.

➡️ Treating the tumor AND the liver matters.