NEURON-GALE

NEURON-Gale | First-in-class Galectin-3 inhibitors for AD | Targeting neuroinflammation at its source | Powered by @Cerebrum_DAO

[NEURON-GALE @NEURONGale]

In 2026, we'll test our inhibitor in mouse AD models, measuring inflammatory markers, plaque load, and cognitive function.

The vision is a new class of drugs that broadly treats neuroinflammation. One target with applications across multiple diseases.

[Cerebrum DAO 🧠 @Cerebrum_DAO]

Waves was founded by Cerebrum DAO's Brian Magierski and Dr. Rudy Tanzi, one of the world's most cited Alzheimer's researchers.

At the center of Waves is Celeste – a next-gen AI coach for supporting brain health.

Try it for free at https://t.co/a3ww9GSYTq

[NEURON-Percepta @Neuron_Percepta]

Huge development in brain health!

The burning question: there are so many supplements, apps, etc, for physical well-being. So why not the brain?

That question is beginning to find its answer.

[NEURON-GALE @NEURONGale]

Brain health utility phase incoming!

https://t.co/9pncwcgii8

[Cerebrum DAO 🧠 @Cerebrum_DAO]

MAJOR ANNOUNCEMENT ‼️

Cerebrum DAO has partnered with Waves – a browser-based brain health platform grounded in world-class neuroscience.

At the center is Celeste, an AI coach built on SMART (Strategic Memory Advanced Reasoning Tactics), a cognitive neuroscience methodology developed at the UT Dallas Center for BrainHealth:

→ 25+ years of peer-reviewed RCT evidence
→ Validated in 3,966 adults over 3 years
→ Published in Scientific Reports (Nature Portfolio), May 2026

It's time to https://t.co/OhAwxxVCn4

[Transfidelity @Transfidelity_]

In the latest @Cerebrum_DAO AMA, we discussed Transfidelity's progress.

Drug rescuing typically refers to identifying new therapeutic uses for drugs that were previously shelved, archived, or failed in clinical trials.

This has become a project with genuine novel chemistry, and while progress is steady, we're heading in the right direction.

[Cerebrum DAO 🧠 @Cerebrum_DAO]

Percepta is our flagship product at the Cognition store, but we're working on some new, exciting additions very soon.

Try Percepta for the first time and get 15% off with code CLAW15.

https://t.co/kh2PFDfHUj

[Cerebrum DAO 🧠 @Cerebrum_DAO]

In our science AMA, we discussed the exciting area of brain lipid research and its connection to neurodegeneration.

We welcome proposals or ideas from any researchers with projects in this area. Since research is outstripping funding, this is the exact gap we seek to fill.

[Cerebrum DAO 🧠 @Cerebrum_DAO]

5th Edition is already here, join @DeSciBerlin on 18th/19th June 2026 - looking forward to seeing everyone there!

[NEURON-GALE @NEURONGale]

NEURON-Gale update ‼️

A research group at Fujian Medical University designed a galectin-3 inhibitor using AI screening – blood-brain permeable – and tested it in the 5xFAD mouse model, one of the most established models in Alzheimer's research.

Over 30 days of treatment, it produced a significant reduction in amyloid burden.

We've been watching galectin-3 for a while. It's elevated in Alzheimer's brains, drives microglial neuroinflammation, and connects to TREM2 and the NLRP3 inflammasome.

We're now setting up a replication study to add biomarkers and stress-test the findings.

[Cerebrum DAO 🧠 @Cerebrum_DAO]

Cerebrum DAO Science Ask me Anything Science Session https://t.co/Km31yFXV8U

[NEURON-Percepta @Neuron_Percepta]

The NEURON-Percepta project tokenized a patent-protected, globally successful supplement, funded a community-led clinical trial, and is now executing on that trial.

If that isn't a true success story of what DeSci can do, we don't know what it is.

[Cerebrum DAO 🧠 @Cerebrum_DAO]

We're hosting a live science AMA on Wednesday, May 13 at 17:00 CEST.

Hear updates on our four active IPT projects – @Neuron_Percepta, @FissionBioDeSci, @Transfidelity_ , and @NEURONGale – and ask our science team anything about the research we're funding.

RSVP on Luma: https://t.co/0y7ellcOZ6

[FissionBio @FissionBioDeSci]

Something big is coming for $MITY.

So far: 15 high-affinity hits. 1B+ compounds screened.

A target that sits at the heart of Alzheimer's, Parkinson's, ALS, and Huntington's.

Watch this space.

[Cerebrum DAO 🧠 @Cerebrum_DAO]

A few minutes. Three cognitive domains.

Most people have never had a baseline for their brain.

Cortex gives you one – a Brain Health Score you can track as you make changes to your life.

Let's make brain health actionable!

#BrainHealthUtilityPhase

https://t.co/tLHbvJpyzf

[Cerebrum DAO 🧠 @Cerebrum_DAO]

Try Percepta from Cognition with 15% off with CLAW15.

A natural plant-based supplement for memory and cognition support, backed by 30+ patents, tokenized as $CLAW at @Neuron_Percepta.

https://t.co/qR9c0zLdR9

[Cerebrum DAO 🧠 @Cerebrum_DAO]

Complete your first Brain Health Survey on Cortex and earn 100,000 NEURON!

Those tokens will eventually connect to staking rewards and discounts on research-backed supplements in the Cognition store.

Just minutes to get started.

https://t.co/tLHbvJpyzf

[NEURON-GALE @NEURONGale]

Treating neuroinflammatory disease with galectin-3 inhibitors from our GALE project has taken a step forward with the discovery of a blood-brain barrier-permeable galectin-3 inhibitor, developed using AI and animal models by a team from Fujian Medical University, Fuzhou, China.

They demonstrated clear pharmacological and clinically relevant effects in a widely used Alzheimer's Disease model, despite the low potency and limited brain exposure.

We are inducting this new information into our study design.

[NEURON-GALE @NEURONGale]

Brace for the brain health utility phase - this will be a game-changer.

#BrainHealth #ENDALZ #Cognition #DeSci

[Cerebrum DAO 🧠 @Cerebrum_DAO]

Brain health tracking has been a long time coming.

We all inherently know that certain lifestyle choices and activities affect our cognition and well-being.

But the brain is exceptionally complex - and it's common to feel overwhelmed and directionless about what to improve and why.

We want to change that with Cortex. Lock in your account, claim your $NEURON - phase 2 coming soon!

https://t.co/EJCEiVRJDg

[Cerebrum DAO 🧠 @Cerebrum_DAO]

GALE - $GALE - @NEURONGale

Galectin-3 is elevated in Alzheimer's brains. When researchers remove it in mice, plaques reduce, and cognition improves. No drug currently exists that can block it inside the brain.

$712K raised in 24 hours. In vivo mouse studies beginning soon.

[Cerebrum DAO 🧠 @Cerebrum_DAO]

Four brain health IPT projects.

All funded by the community. All targeting different mechanisms behind neurodegeneration.

Here's where each one stands today. ⬇️

[Cerebrum DAO 🧠 @Cerebrum_DAO]

We all probably know something about the benefits of creatine, so we've added it to the Cognition store.

Supplied by one of the world's leading suppliers and 100% pure.

By supporting us through Cognition, you support the DAO's continued operations and research.

We really appreciate it.

https://t.co/LgK31vhact

#BrainHealth