Tomoo Ogi

Professor of Genetics, Graduate School of Medicine, Nagoya University, Japan; Research Institute of Environmental Medicine (RIeM), Nagoya University, Japan

[Journal of Clinical Investigation @jclinicalinvest]

Commentary: Expanding the landscape of nucleotide excision repair disorders: from discovery to therapy: https://t.co/4YxliTeibO

Arjan F. Theil & Jan H.J. Hoeijmakers discuss companion articles by Tomoo Ogi & team: https://t.co/TdPWOilzPu
https://t.co/fETDtfYuVJ

[Nature Reviews Molecular Cell Biology @NatRevMCB]

New Online! Mechanisms of transcription-coupled repair and DNA damage surveillance in health and disease https://t.co/PiXBebKU8L

[Martijn Luijsterburg @luijsterburglab]

Our protocol for imaging-based quantification of RNAPII clearance during transcription-coupled DNA repair is now online👇

Well done Bram, Diana and Paula!

https://t.co/muVkBP0XoW

[rinku majumder @rinkumajumder]

Thrilled to share our new publication in JCI today! 🎉
We show that estrogen and obesity synergistically suppress Protein S through HIF-1α, creating a prothrombotic environment.
Grateful to my team and collaborators for their incredible work.
#JCI, # LSUHealth

[Journal of Clinical Investigation @jclinicalinvest]

TFIIH-p52ΔC defines a ninth xeroderma pigmentosum complementation–group XP-J and restores TFIIH stability to p8-defective trichothiodystrophy

[Journal of Clinical Investigation @jclinicalinvest]

This issue’s cover features companion papers that exemplify how understanding a #RareDisease can inform treatment strategies in other conditions.

Fassihi et al. and Nakazawa et al. report on the C-terminal deletion of transcription factor TFIIH-p52 subunit as a cause of #XerodermaPigmentosum.

The cover art was created using PyMOL; TFIIH-p52 subunit (blue; C-terminus in white). Image credit: Keiko Itano.

https://t.co/MbdGbQxWFP
https://t.co/P4WGX4uFfD
@KotaroTsukada @NagoyaUniv

[Martijn Luijsterburg @luijsterburglab]

@orlandoscharer Very beautiful! The cherry blossoms in our street are also in bloom!

[Orlando D. Schärer @orlandoscharer]

🌸🌸At least the cherry blossoms are not cancelled on our campus 🌸🌸

[Tomoo Ogi @OgiTomoo]

https://t.co/h6Bz2MIU2k

[Tomoo Ogi @OgiTomoo]

#AMED Multi-omics Analysis Centre at Nagoya University has just published a paper describing molecular pathogenesis of #Cockayne syndrome.
Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair https://t.co/AzQz80op7B

[Ana Tufegdžić Vidaković @ana_tufegdzic]

Published yesterday! Surviving DNA damage requires more than just repairing DNA damages - a dramatic regulation of the transcriptome, via a novel modification of RNA Pol II. You can read about our work here (open access!): https://t.co/ApTmYYI50V

[Martijn Luijsterburg @luijsterburglab]

Our collaboration with the lab of Tomoo Ogi is now online in Cell!

Ubiquitylation of RNAPII regulates DNA repair and protects against persistent stalling and neurodegeneration!

https://t.co/hXZf6ntghk

[Tomoo Ogi @OgiTomoo]

#AMED 名大オミックス解析拠点から #コケイン症候群 の病態理解につながる論文がCell誌に報告されました。転写共役修復の開始反応の分子メカニズムの一端が明らかになりました。
https://t.co/kamP5pRTGf
https://t.co/JF00MyHzzo

[Prof Patrick Eyers @Pseudoenzyme]

Single site ubiquitination of RNA Pol II at Lys1268 controls UV-induced DNA damage response. Looks like a very fundamental mechanism in biology!

[ChromoTek @ChromoTekGmbH]

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair
#GFP #immunoprecipitation #ubiquitin
https://t.co/dhVZaPWiXh

[Cell @CellCellPress]

In the latest issue: #OpenAccess control of pool of available #RNA polymerase II shapes how #cells respond to #UV stress and the efficacy of resulting #damage response https://t.co/FtndwDNKWA

[Christian Reinhardt @chr_reinhardt]

The DDR continues to amaze me. Wonderful work! Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair: Cell https://t.co/Kh4VX3VGaP

[LUMC Leiden @LUMC_Leiden]

Struikelblok op DNA lijkt oorzaak van zeldzame #Cockayne syndroom. Lees meer over dit onderzoek van @luijsterburglab 👇
https://t.co/NNg6S3G6qR

@AmyandFriendsNL

[Orlando D. Schärer @orlandoscharer]

Here is some shutdown reading while you are trying to relax on your couch at home: A preview I wrote with Kook Son on two papers from the Ogi and Svejstrup laboratories on how RNAPII ubiquitination affects transcription and repair https://t.co/KtgIqHehNU.

[Cell @CellCellPress]

In the latest issue: #ubiquitination of #RNA polymerase promotes recruitment of TFIIH and initiation of #transcription-coupled #repair whose dysregulation in mice cause neurological consequences #CockayneSyndrome https://t.co/dWp8M1qAZm