Oon-Tek

Infectious Disease Physician. Posts mainly on ID and AMR topics and research.

[Yong Loo Lin School of Medicine @NUSMedicine]

In a four-year long clinical study, lead study author Dr Mo Yin from #NUSMedicine discovered that a shorter course of #antibiotics is as good as the standard course of antibiotic treatment for patients with ventilator-associated #pneumonia : https://t.co/4qXmDH4ZQ8

[Oon-Tek @OonTek1]

CaPES group looking for a bioinformatician interested in Gram -ve WGS and plasmid transmission. Working with CRO collection in Singapore and with @ADVANCE__ID. Application link below.

@kalisvar @davidantibiotic

https://t.co/kfrkvjlLFq

https://t.co/BO5Ska1oiN

[ADVANCE-ID Network @ADVANCE__ID]

ADVANCE-ID has collaborations with over 50 hospitals in Asia. Our clinical trials hub is at NUS in Singapore with leadership provided by @davidantibiotic and @InfectiousMoYin . There is also central genomics support at Singapore's NCID from @kalisvar and @OonTek1

[A*STAR Genome Institute of Singapore (A*STAR GIS) @astar_gis]

Long-term colonization of the gut microbiome by CPE is a growing area of public health concern. Study shows how colonization by multidrug-resistant bacteria associates with altered gut ecology & allows transfer of resistance genes.
🔗: https://t.co/1mDfIutCfg

[Kalisvar Marimuthu @kalisvar]

An excellent keynote address on WGS in IPC by @drdavideyre at the CaPES symposium 2022 in Singapore by the Carbapenemase producing Enterobacterales (CaPES) study group. @OonTek1

[Niranjan Nagarajan @NiranjanTW]

Excited that our work on tracking Carbapenemase-producing Enterobacteriaceae in the gut microbiome is finally out open access! The result of great bench-to-bedside collaborations with @kalisvar @OonTek1 @yunnhwen
Highlights thread: https://t.co/v6poLvwts7
https://t.co/hDmwrrg8tL

[Nature Microbiology @NatureMicrobiol]

OUT NOW 👉Long-term ecological and evolutionary dynamics in the gut microbiomes of carbapenemase-producing Enterobacteriaceae colonized subjects

by @NiranjanTW & co

https://t.co/DsFnDIlfAu

[Isaac Bogoch @BogochIsaac]

The current COVID vaccines continue to provide excellent protection VS *severe* infection.

In the Omicron era, protection VS infection wanes in ~2 months (even with a 3rd dose).

Good data from Singapore, adding to the growing body of evidence.

https://t.co/gQqIkiPBSp Ng et al.

[Shirin Kalimuddin @shirinklmddn]

3 dose mRNA vaccination more effective in preventing severe covid than 3 dose inactivated vaccine, during Omicron wave in Singapore. Study by Oon Tek Ng and @kalisvar et al. https://t.co/nbZNSg3bVW

[Eric Topol @EricTopol]

Vaccines and boosters during the Omicron wave in Singapore, among >2.4 million people, age 30+
https://t.co/3xcqqzow0h
3 shot mRNA, vaccine effectiveness
vs. Confirmed Infection 31-41% to 2 months, marked waning thereafter
vs. Severe Disease 87%, 5-6 months

[Oon-Tek @OonTek1]

@yunnhwen Looking forward to finding out!

[AMR Action Fund @AMRActionFund]

Hospital stays were 42.1% longer in carbapenem-resistant infections compared with carbapenem-susceptible cases and 50.4% more expensive. The world cannot afford inaction on #AMR.

[Laura Piddock 💙 @LauraPiddock]

#AMR in LMICs: ‘The power of genomics to expose transmission channels & hotspots is largely unharnessed, & that existing & upcoming technological innovations need to be exploited’ https://t.co/bKxz7IGWJs

[Oon-Tek @OonTek1]

Trend figure showing decline in clonal transmission (direct ward contact related) (blue line)

[Oon-Tek @OonTek1]

Excited to see CaPES group results (short/ long-read WGS) - 5 year CPE spread across Singapore public hospitals (779 pts, 1215 isolates):
https://t.co/TU594gXgZk
Tks @kalisvar 4 extensive discussions. Also
@eliowa @hsuliyang @10minus6cosm @NicStoesser
@drdavideyre

[Oon-Tek @OonTek1]

Tks all for the collab effort esp @kalisvar and team for the collation and analysis of epi data...

[Kam-Yung Soh (mstdn.io/@sohkamyung) @sohkamyung]

A look inside this mozzie factory.
"The Straits Times visited the National Environment Agency's (NEA) Wolbachia mosquito production facility - the only one in Singapore - to find out the battle plan being drawn up behind the scenes."
@Mozziebites
https://t.co/c6YSQqeDmX