We know that the progesterone hormone levels in the body increase in the post-ovulatory phase of the cycle, since it's produced by the corpus luteum tissue, which is present after ovulation. In a normal cycle, the corpus luteum usually dissolves up to 17 days after ovulation (if the woman is not pregnant), ceasing progesterone production until a new corpus luteum forms in the next post-ovulatory phase. At the end of the cycle, the progesterone hormone therefore returns to its negligible pre-ovulatory levels.
The inventors of the birth control pill used this knowledge of the varying levels of estrogen and progesterone throughout the phases of a normal cycle to their advantage. What would happen if a woman didn't have a cycle where estrogen rose in the pre-ovulatory phase and progesterone rose in the post-ovulatory phase? What would happen if the woman's hormones were flatlined such that they remained the same levels each day from taking a hormonal pill that contained estrogen and/or progesterone? A synthetic version of progesterone, called progestins, was created to act like progesterone. Progesterone is normally only present in higher levels after ovulation, so if present in high amounts before ovulation, the body can basically "get confused" and it can mess up ovulation. The birth control pill primarily works pre-ovulation to stop the body from ovulating, thicken the cervical mucus (so that sperm cannot survive in it like they can in fertile cervical mucus for up to 5 days), and thin the endometrium (uterine lining) to make the uterus inhospitable to an embryo should conception happen. So, not only is the birth control pill contraceptive, but some also view it as abortifacient.
The invention of the birth control pill created a way that couples could "easily" avoid pregnancy (if the woman remembers to take the pill at the same time each day), even though the Pill can fail (7% typical use failure rate or 93% effective according to CDC) and can come with many additional negative side effects (that we won't mention fully here), some of the worst being a high risk of blood clots in some women (that can result in death) as well as a higher risk of some cancers like breast cancer and cervical cancer (again, that can result in death). Furthermore, the Pill is also not only used for family planning. The Pill is often given as a "quick fix" to cover up many women's health issues by suppressing (shutting down) ovulation and the menstrual period. For example, if a woman complains of heavy periods and painful periods, wouldn't it be "fixed" if she just doesn't have a period anymore? Of course, making a woman temporarily not have a menstrual period by taking a pill is not the real solution and does not address the problem at its root cause. Regardless, due to the Pill's popular use in both family planning and "women's health," many women live years without their natural ovulation and menstrual cycles or their natural, cycling hormone levels.
How do you think having progesterone (or progestins) in the body daily or almost daily (maybe only stopping the pill for a short time each month to get a withdrawal bleed or a "fake menstrual period") for extended lengths of time can affect a woman?
As a FertilityCare Practitioner, we realize that not all pregnancies are planned and also that not all pregnancies are wanted. We ask these tough questions to women and couples and have these discussions in our regular follow-ups as well as during our special Pregnancy Evaluation appointments.
The medical community already knows the power of progesterone for pregnancy. The two-step protocol to medically induce an abortion involves taking mifepristone (RU-486) as the first pill, followed by misoprostol as the second. Mifepristone (RU-486) initiates the process by blocking progesterone receptors in the uterus and placenta. Progesterone is essential for maintaining pregnancy: it prepares and sustains the uterine lining (endometrium) for implantation, suppresses contractions, and supports the overall environment. By antagonizing (blocking) these receptors, mifepristone prevents progesterone from exerting its effects, leading to a breakdown of the uterine lining (decidual necrosis), cervical softening and dilation, increased sensitivity to prostaglandins (natural chemicals that promote contractions), and the release of endogenous prostaglandins from the endometrium. This makes the uterus less supportive of an existing pregnancy, essentially detaching the embryo and preparing for expulsion. The second pill, misoprostol, taken within 24-48 hours later, is a prostaglandin analog that further induces strong uterine contractions and expels the contents, completing the abortion.
NaProTechnology has an "abortion pill reversal" protocol available for women who took mifepristone (RU-486), but not misoprostol yet. This intervention involves giving high doses of progesterone, aiming to "reverse" the process. The idea is to flood the system with excess progesterone to outcompete mifepristone for the receptor sites, potentially restoring progesterone's supportive effects and allowing the pregnancy to continue. Abortion pill reversal with the use of progesterone medication has been reported to work in some cases to continue pregnancies, with proponents citing success rates of 60-70% in observational data if initiated within 24-72 hours, and some reports indicating no increased risks of birth defects or long-term harm to the mother or baby based on available data, though more research is needed. As with any medical intervention, potential side effects like bleeding or incomplete reversal should be discussed with a provider. (This is not medical advice; always consult your healthcare professional.)
What are your thoughts on progesterone's role here? Open to respectful discussion!
I just wrote a new article in a couple hours titled "Progesterone Saves Lives," which I've wanted to write since Chelsea was born, but never had the time or mental clarity! So happy to see this now on paper and ready for the world to read! If you are on X, please like and share so that this article goes viral! #milliondollararticle #progesterone #prolife :D
https://t.co/RwZJhv4Dfx