MP Pebworth

Computational Biologist & Father
Allen Institute for Immunology

[Caleb Lareau @CalebLareau]

A history of viral encephalitis is one of the strongest risk factors for developing dementia. With @JacobJacobog02, Yifan Chen, @RNA_Life, and @RyanDhindsa, we refine this link by describing a neuronal cell type that can reactivate HSV-1 in humans 1/n

https://t.co/y8D2orzUur

[MP Pebworth @PebworthMark]

@SallyCat3 @micyoung75 Probably wouldn't be much cheaper. It's a bespoke medicine, created as a one-off combination and formulated for his specific body and weight. do you know how complex that is? there's a reason that medicines like that aren't an option in most of Europe. the state wouldn't cover it

[MP Pebworth @PebworthMark]

@MadMadViking @komonews Do you have a link? Taxing something typically decreases it's availability/use so I'm honestly really curious. I hate the bag tax- I just use my own on principle.

[Tanzila Mukhtar- Warrior @tmturkee]

Thrilled to share this amazing team effort, huge thanks to @Kriegsteinlab and everyone who made it possible! Big congrats to @SiebertClara, Dr. Yuejun Wang, @PebworthMark . Grateful to lab members for the insightful discussions and support throughout!🥂❤️
https://t.co/8hhwdcKgZQ

[MP Pebworth @PebworthMark]

@redviolet1458 @komonews Ah, so you'd rather make your life worse just to get back at people over a perceived unfairness?

[MP Pebworth @PebworthMark]

@redviolet1458 @komonews You know that only makes your experience of traffic worse, right? More remote work= less traffic for you

[MP Pebworth @PebworthMark]

@613weilin Why did you use gene density?
most enhancers are at least one or two jeans away, so the number of peaks or genes between a promoter and a potential enhancer is irrelevant.

[MP Pebworth @PebworthMark]

@Strandjunker The man's old enough, he could die of natural causes at any point.
Let's not get carried away.

[MP Pebworth @PebworthMark]

@c0nc0rdance Or 2018: "Single cells were picked into cell lysis buffer by mouth pipette and reverse
transcription was performed as described for Smartseq"
This is from a Nature paper analyzing human brain tissue, btw.
https://t.co/WsgNrSnRj7

[MP Pebworth @PebworthMark]

@lpachter Not too long ago, I found a paper that listed mouth pipetting in the methods- to process dissociated human brains for single cell sequencing.... :(

[MP Pebworth @PebworthMark]

@WiringTheBrain @Heisenblurb This is 💯 how most of the literature discussed proteins.
I like how you recast that notion into properties instead. How would you alter systems biology approaches with this in mind?

[MP Pebworth @PebworthMark]

@NeuroLuebbert That's... a bizarre and uncomfortable email. Sounds like in the German context it's worse? Was the entire point of the email to comment on your looks, or was this a random aside?

[MP Pebworth @PebworthMark]

@milleniumfu @komonews Nope, it's very easy for something like this to happen. The local police would easily have assumed he was with the SS- its pretty normal to have snipers on roofs at events like that, until he actually fired.

[MP Pebworth @PebworthMark]

@lpachter @nytimes So start one! Have you considered having phone calls with editors and coordinating with the folks at Retraction Watch? You would just need to set critical standards to prevent people from making false accusations within the journal, or stooping to ad hominem attacks.

[MP Pebworth @PebworthMark]

@ThrillaRilla369 @MattWallace888 This is very misleading. Most of the money that supposedly went to Ukraine actually went to American contractors. Ukraine got a bunch of armaments that were about to expire anyways, meaning that we would have spent money to replace it regardless of whether or not we gave it away.

[MP Pebworth @PebworthMark]

@Kwabzyboy @CliffMass If we want DEI initiatives to be successful, we need people like @CliffMass, who are willing to point out issues with the program. Is it more valuable to pay 100s of administrators or to cover the tuition for thousands of low-income diverse students ?

[MP Pebworth @PebworthMark]

@Kwabzyboy @CliffMass Based on his blog post, the DEI program is completely failing at equity too. They are admitting students who are not prepared, rather than creating programs so that they can catch up- all in the name of looking good.

[MP Pebworth @PebworthMark]

@lpachter At that point, it's called faith, not science.

[MP Pebworth @PebworthMark]

@moorejh @tuuliel_lab again, they're all a mess. You're better off building associative models between paired data sets of epigenetic and gene expression, and testing all possible pairwise associations between gene expression and epigenetically active regions within several megabases of a promoter.

[MP Pebworth @PebworthMark]

@MovieHooligan this is funny, but I can't find the original post. can you provide a link instead of a screenshot?