PippaRT

Likes sun, turquoise, tennis, roses, cheese.

[Sharron Davies HoL MBE @sharrond62]

I can genuinely say I’ve never seen such disregard for women & children’s safety as I have in recent years. From all directions.. the loss of rights & spaces, to paltry sentences for sexual assault & pedophilia, to lack of support for grooming gang enquiries, to school girls having to carry rape alarms, to the gross pornification of the internet … the list goes on & on. We are going backwards in how we treat women & girls

[J.K. Rowling @jk_rowling]

I see Nicola Sturgeon is once again complaining that I posted a picture of myself wearing a T-shirt with her name on it and the legend 'Destroyer of Women's Rights.' Apparently this didn't 'elevate the debate.'

Is there a clinical term for an individual who has extreme thinness of skin when it comes to their own perceived hurts, coupled with a rhino-hide when it comes to the fear and suffering of others?

I'm thinking in particular of the two women Isla Bryson raped, who had to watch their First Minister squirm and smirk on TV as she tried to avoid admitting he was a man; of the five survivors of male violence who were ready to give evidence to Sturgeon's committee on gender self-ID, but were told to put their concerns in writing while seventeen trans-identified people appeared in person; of the mother of a young girl with a learning disability who campaigned against self-ID because she wanted her daughter to be guaranteed same sex intimate care, should she need it (the mother was presumably one of those female opponents Sturgeon calls 'shrill' and 'hysterical' in her memoir); of the ten-year-old girl sexually assaulted in a public bathroom by a 6'5" paedophile who served his jail sentence in a women's prison because he called himself 'Katie'; of Sandie Peggie, forced to discuss her own menstrual history in public to justify not wanting to undress in view of a 6ft straight cross-dresser in the nurses' changing room; of Marion Millar, dragged into court because she tweeted a picture of suffragette ribbons; of the Scottish rape crisis centres reliant on government funding who were pressured to admit trans-identified males into their services if they wanted funding to continue.

When Sturgeon refers to an 'elevated debate', she means a discussion that takes place within a tiny, smug bubble from which regular women suffering real life consequences of her policies are firmly excluded. These faceless ants are loftily dismissed as bigots, or, to be more precise: 'transphobic, misogynistic, homophobic, maybe racist as well.'

Nicola, you hated the T-shirt picture because you couldn't ignore it, as you'd ignored so many other women trying to make you understand their concerns. Appeals to your empathy, your intelligence and your compassion all failed. Apparently the only way to get through to you is through your vanity.

[Paul Mason MD @DrPaulMason]

The widespread misuse of Ozempic is leading us headlong into a tsunami of osteoporis and sarcopenia (muscle weakness). In this note for my patients, I detail the evidence that clearly demonstrates this is not a drug to be taken lightly. If you know anyone prescribing Ozempic, they should read this.

Ozempic - a disaster waiting to happen
Glucagon-like Peptide-1 (GLP-1) is a key hormone regulating energy balance. It's release can be heavily influenced by processing of food, such as grinding, milling, or juicing, which can increase how quickly it is absorbed.

One key mechanism of GLP-1 is to suppress secretion of the hunger hormone, ghrelin, thereby suppressing hunger. GLP-1 itself is secreted by L-cells in the lower small intestine in response to the presence of nutrients incluiding carbohydrate, protein, and fat. The location of L-cells far down the small intestine is significant, as rapidly digested processed foods may not reach this far. Consequently processed foods may not stimulate an appropriate increase in GLP-1 levels, leading to persistently high ghrelin levels and hunger. This explains why one can often continue consuming large amounts of processed foods without experiencing true satiety.

Ozempic (Semaglutide) mimics the effects of natural GLP-1 but has a longer duration of action, explaining its profound appetite-suppressing effects. However, mucking around with human physiology can often have unintended consequences.

One of the trials used for the approval of Ozempic was a a drug company-funded trial known as STEP1. It demonstrated impressive weight loss over 68 weeks of once-weekly injections, the more than 1,300 participants experiencing an average weight loss of 16.86 kg (37lbs). As always however, the devil is in the detail. DEXA body composition scanning was performed on 95 of the STEP1 subjects, and revealed first of all that less than 5% of fat lost was the more problematic visceral fat. Even more concerning, 41% of the total weight lost appeared to come from muscle and bone. You read that correctly. These subjects were on a path both to osteoporosis and sarcopenia (excessive muscle loss).

This obvious raises questions about the impact of Ozempic on bone health. A double-blinded, randomised controlled trial was subsequently conducted at two public hospitals in Denmark. This study also found impairment in bone health, weekly semaglutide injections over 52 weeks resulting in bone mass loss in the lumbar spine and hip, as well as thinning of the outer strong cortical bone of the tibia. Perhaps even more concerningly however was that levels of the bone resorption marker C-terminal telopeptide (CTX) continued to rise throughout the study. This suggests that not only is bone loss ongoing while taking semaglutide, but the rate of bone loss may even accelerate with prolonged used. I cannot emphasise this enough. The longer subjects take semaglutide, the closer to osteoporosis they likely get.

Which then raises the question of what happens when semaglutide is ceased? Does bone mass return. Unfortunately we don't know the answer to this question, because the drug company funded follow-up to the STEP1 trial, which followed subjects for 12 months after discontinuing semaglutide only reported on weight, not body composition. Still even looking only at weight, the results were not good. Participants regained on average two-thirds of the weight they had lost. Given that 59% of the initial weight loss was fat, it is plausible that the regained weight was primarily composed of fat. It is perhaps unlikely that if indeed these subjects had only regained muscle and bone, that we would not have been told about it.

Additionally, the STEP1 trial found treatment with semaglutide to be associated with significant increases in the pancreatic enzyme lipase (rising from 25 U/L to 36 U/L). This is concerning given that Roche withdrew another GLP-1 agonist, Taspoglutide, due to severe side effects, including pancreatitis. Similarly, Exenatide (Byetta), another drug in this class, carries a black box warning for both pancreatitis and kidney dysfunction.

There are of course other issues with this class of drug, however I think these alone justify severe caution be used when prescribing it. The fact is, it is very likely that the longer you are on this drug, the weaker your bones get. And with no evidence that this bone mass returns when it is stopped, we may well be facing a future tsunami of premature osteoporosis and sacropenia in coming years.

https://t.co/Pzc03dWHU3
https://t.co/O55gB7Fc2I

[PippaRT @Pippa_RT]

@marksandspencer Thank you

[PippaRT @Pippa_RT]

@marksandspencer the changing rooms at your #Shrewsbury store are filthy. I got covered in dust and fluff when trying on some jeans, yuk! Raised it with a colleague; they shrugged.

[PippaRT @Pippa_RT]

@TheChiefNerd Complete disregard for the human price and extreme suffering caused by “learning as you go”. Appalling lack of empathy

[PippaRT @Pippa_RT]

@afneil 😂😂

[PippaRT @Pippa_RT]

@Ed_Miliband Oh pi** off.

[PippaRT @Pippa_RT]

@leeharris Despicable.

[PippaRT @Pippa_RT]

@Keir_Starmer What does “fire up our industrial heartlands” actually mean? What “industries of the future?” Spin. Jargon. Vacuous. Pure nonsense.

[PippaRT @Pippa_RT]

@darknessofmice @BLAIMGame An unqualified celebrity running a care home for society’s most vulnerable children?? Anything to do with making £10k per child per week, housing up to 4; that’s nearly £2million a year before costs. These kids deserve better. They deserve a safe haven. Fuming.

[Dr Katie Musgrave @dr_musgrave]

I don’t believe the UK has the capacity to safely bring in assisted dying:

Our healthcare system is under too much strain.
It is (by design) discriminatory.
A fundamental shift in how we treat elderly/ disabled.
Impossible to prevent coercion.
Financial incentives astronomical.

[James Melville 🚜 @JamesMelville]

Labour MP Rosie Duffield has resigned the Labour whip with immediate effect. Her resignation pulls no punches:

“As Prime Minister, your managerial and technocratic approach, and lack of basic politics and political instincts, have come crashing down on us as a party after we worked so hard, promised so much, and waited a long fourteen years to be mandated by the British public to return to power.

Since the change of government in July, the revelations of hypocrisy have been staggering and increasingly outrageous. I cannot put into words how angry I and my colleagues are at your total lack of understanding about how you have made us all appear.

How dare you take our longed-for victory, the electorate's sacred and precious trust, and throw it back in their individual faces and the faces of dedicated and hardworking Labour MPs?! The sleaze, nepotism and apparent avarice are off the scale.

I am so ashamed of what you and your inner circle have done to tarnish and humiliate our once proud party.”

[Isabel Oakeshott @IsabelOakeshott]

ABSOLUTE CAR CRASH

[Andrew Neil @afneil]

This we only learned last night:
Chancellor Rachel Reeves accepted £7,500 in donations for clothing but it was registered vaguely as “support” for her office.
So much for the promised transparency
Deputy PM Angela Rayner accepted clothes worth £3,550 declared confusingly as a “donation in kind for undertaking parliamentary duties”.
So much for transparency
In addition to that £3,550 “donation in kind”, Rayner also received £8,500 last October, £8,250 in March and £900 in April from Labour moneybags Lord Alli, declared as money to “support” her in her “capacity as deputy leader of the Labour Party”.

[Shabnam Nasimi @NasimiShabnam]

Women in Afghanistan are being obliterated—no voice, no face, no existence. The Taliban’s latest decrees are nothing short of barbaric: women banned from singing, reciting poetry, or even speaking aloud in public. Their faces and bodies must hidden from the world.

This isn’t just an Afghanistan tragedy; it is a stain on the global conscience, brought about by our failure to act.

[PippaRT @Pippa_RT]

@nick_dece Wow.

[PippaRT @Pippa_RT]

@sharrond62 I’m really confused after all this conflicting media coverage. Was this boxer born a female or not? If so, it’s clear that we cannot have male biology with female biology in the ring due to undue threat of serious injury or death.

[Sharron Davies HoL MBE @sharrond62]

I’m horrified at the number of men either presenting or hosting tv/radio shows that think it’s ok if ‘maybe’ a male is boxing females? At the very least we should be demanding the IOC don’t rely on a passport as biological proof, especially when these individuals have failed sex tests & both decided NOT to contest that decision

[PippaRT @Pippa_RT]

@greg16676935420 Missed it….and no trace on social media…erased. Not even citizen journalism?