Plath Lab

Twitter feed for the laboratory of Prof. Kathrin Plath @UCLA

[Plath Lab @PlathLab]

📢 Ready to rethink XIST? Our latest work, now in Cell, challenges two fundamental assumptions about XIST: its cis-limited action, and its role in equalizing gene expression between XX and XY genotypes.
Dive in 👇🤿(1/6)
https://t.co/7HuWdR6sFi

[Plath Lab @PlathLab]

@SridharanLab @ISSCR @ChronisLab @RitchieHoLab @vincentpasque was fun seeing you all! Great meeting!

[Plath Lab @PlathLab]

@martinperaJAX Thank you Martin - Congratulations Janet!

[Siavash Kurdistani @VashKurdistani]

Excited to share our latest work: L126 fine-tunes enzymatic activity of histone H3, a discovery made possible by viewing the nucleosome as an enzyme. We have a gain-of-function mutant – it’s hard to enhance an activity if it doesn’t already exist! https://t.co/RB4tEhKszU

[Andrea Cerase @andrea_cerase_]

I'm delighted to have been mentioned in the celebratory article commemorating the 30th anniversary of NSMB #Xist_granules #phase_separation @tartaglialab @mitchguttman @PlathLab @NatureSMB https://t.co/0Dt9Hbuylp

[Plath Lab @PlathLab]

One of the most extensively studied lncRNAs continues to surprise us! A huge thanks to everyone who helped with this! @Iris_Dror @tsotnech @ClaraCanCanoe @Dr_Sahakyan @YolandaMarkaki @ChronisLab @Mandy_Collier @WeixianDeng @DingFangyuan, #lncRNA, #SexDifferences (6/6)

[Plath Lab @PlathLab]

Applying RAP-seq, we found that XIST spreads across the X and, surprisingly, also to autosomal genes. Autosomal targets show female-specific and XIST-dependent H3K27me3 and downregulation of gene expression, indicating that XIST enforces sex differences on autosomes. (3/6)

[Plath Lab @PlathLab]

This raises the possibility that autosomal genes in other cell types with a dispersed XIST configuration (pre-implantation embryos, germ cells, immune, lung, and cancer cells) may be regulated by XIST. (5/6)

[Plath Lab @PlathLab]

In female na��ve human pluripotent stem cells (PSCs), XIST is dispersed in the nucleus and X-chromosome dampening (XCD) occurs, raising the question of whether XIST mediates XCD. Knocking out XIST, we found that it is required for XCD in naïve hPSCs. (2/6)

[Plath Lab @PlathLab]

📢 Ready to rethink XIST? Our latest work, now in Cell, challenges two fundamental assumptions about XIST: its cis-limited action, and its role in equalizing gene expression between XX and XY genotypes.
Dive in 👇🤿(1/6)
https://t.co/7HuWdR6sFi

[Plath Lab @PlathLab]

In collaboration with @dinodicarlo, we used hydrogel nanovials to capture and measure the secretion of VEGF-A alongside mRNA transcriptomes. Surprisingly, we found that the VEGFA transcript was not the best predictor of secretion! 2/2

[Plath Lab @PlathLab]

Check out our latest publication where we developed SEC-seq – a new technology that captures and measures single-cell protein secretion coupled with mRNA transcriptomes published in Nature Nanotechnology! https://t.co/L0SRssYNNv
1/2

[Plath Lab @PlathLab]

Congratulations to Plath lab member @JustinLangerman who was awarded the UCLA 2023 Boyer/Parvin Postdoctoral Award. 🎉

[JonesLabUCSF @JonesLabUCSF]

Join us for this incredible @GordonConf on #StemCells and #Cancer in beautiful #Tuscany organized with @CedricBlanpain and @PlathLab!!🔬🧐🇮🇹

[Plath Lab @PlathLab]

This work was led by @JustinLangerman and @shreya_udani with the @Dinodicarlo lab

[Plath Lab @PlathLab]

It's time to bring single cell secretion measurement into the multiomics family! Check out our recent BioRxiv submission where we found unexpected relationships between VEGF-A secretion, the VEGFA mRNA, and the cell state: https://t.co/8IwboJ4lVc

[Ben Novitch @NovitchLab]

I’m happy to share our new paper with @LabMomoko published today https://t.co/tN0rCaI8f8 which examines how differences in the state of human stem cell pluripotency can lead to favorable or unfavorable outcomes when making brain organoids.

[Plath Lab @PlathLab]

Congratulations to @YolandaMarkaki and all other award winners for the UCLA 2022 Boyer/Parvin Postdoctoral Award. Tune in for her seminar on "How to silence a chromosome" July 20th at 12PM PT. 🧬

[Tracy Tran @TTdevbio]

It’s finally out! Many thanks to my colleagues @jacksongcheng and my mentor Andy McMahon at USC for making this happen. #organoid #kidney #screen

[Plath Lab @PlathLab]

Excited to share our recent review on the role of Xist in maintaining X inactivation!

https://t.co/2Cr6bZFNW3

By @Elsie_youlater and Amy Pandya-Jones