Marc Raab, MD, discussed cure in the context of the GEM14MAIN & MajesTEC-5 data shared during #IMS26. He also summarized studies on improving CAR-T safety and monitoring/managing bone disease during the Highlights session. @RaabMarc
#IMS26 Tal-DR in newly diagnosed ASCT-eligible myeloma. More excellent MajesTEC-5 by @RascheLeo@RaabMarc et al! 👏
No issues with SC collection. Excellent response 👇🏼. 15% ataxia (all low-grade & recovering) - perhaps combo Tx, or truly more common as tal enters earlier lines?
This weekend, we bid farewell to Hartmut Goldschmidt, who will retire from his academic positions at the end of the month. To celebrate 35 years of @HDMyeloma, 30 years of #GMMG, a large crowd joined us for a dedicated symposium with long-standing partners and friends. #mmsm
Mark your calendars for the 4th Annual Workshop on Genomics. 📅 July 10-11 in Warsaw, Poland. Register today for in-person or virtual attendance! https://t.co/Y3I03jsEqJ
GMMG-HD10/MajesTEC-5 represents an important and likely a watershed moment in myeloma induction and consolidation therapy! Amazing early and deep responses (100% MRD neg rates!!)
👏👏 @RascheLeo@RaabMarc et al.
AntiCD38-based quadruplets set the bar pretty high for early PFS rates PFS and now we have a worthy challenger!
Whether this eventually displaces autologous transplant or not, one thing is for sure—BCMA bispecifics in induction will certainly make all of us think like transplanters when it comes to our infectious disease game (>35% Gr3 infections, 6% CMV reactivation).
Biggest question that will need answering is whether everyone need a BCMA TCE upfront and for how long?
https://t.co/kr380rUtuk
Love seeing triple-digit MRD neg percentages 🤩
Congrats @RaabMarc et al on excellent MajesTEC-5 @NatureMedicine paper!
bsAb-based induction in ND myeloma - may well obviate ASCT.
Top panel = ITT, bottom = MRD-evaluable. Kudos to authors for reporting both sets like this.
#Myeloma Paper of the Day: Teclistamab-based induction in TE NDMM shows MRD- CR rate 91.8% (45/49) by pre-maintenance timepoint, 100% in evaluable samples & post-induction cycle 3 (10-5 (46/46)), 6 (10-5 (46/46) & 10-6 (46/46)); ORR was 100%: https://t.co/JI0HRixT9o. #mmsm
Clinical Scores to Predict Toxicities and Outcomes in Patients with Multiple Myeloma Undergoing Bispecific T-cell Engager Therapy
@BCD_AACR
https://t.co/BjSAYEVbUg
Now online: Clinical Scores to Predict Toxicities and Outcomes in Patients with Multiple Myeloma Undergoing Bispecific T-cell Engager Therapy https://t.co/JvdypWnpvG
Fascinating - albeit a little terrifying - @LeukemiaJnl work by 🇩🇪
How does GPRC5D loss affect surviving myeloma #MMsm clones? Here, remaining cells appear to be more aggressive.
Will be important to validate / rebut as talquetamab moves into earlier lines... hopefully soon!